Nanoparticles and cancer therapy: Perspectives for application of nanoparticles in the treatment of cancers

Aghebati‐Maleki, Ali; Dolati, Sanam; Ahmadi, Majid; Baghbanzhadeh, Amir; Asadi, Milad; Fotouhi, Ali; Yousefi, Mehdi

doi:10.1002/jcp.29126

Cited by 253 publications

(126 citation statements)

References 117 publications

(131 reference statements)

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“…Lately, novel NPs of cerium dioxide (CeO 2 NPs or nanoceria) have attracted the attention of the scientific community because they have been used in a range of industrial, commercial and also biomedical applications [ 6 ]. These include applications as fuel additive-combustion catalyst in gasoline, as additives in cigarettes, in self-cleaning ovens, as polishing agents and in UV protection [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Uptake of Cerium Dioxide Nanoparticles and Impact on Viability, Differentiation and Functions of Primary Trophoblast Cells from Human Placenta

et al. 2020

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The human placenta is at the interface between maternal and fetal circulations, and is crucial for fetal development. The nanoparticles of cerium dioxide (CeO2 NPs) from air pollution are an unevaluated risk during pregnancy. Assessing the consequences of placenta exposure to CeO2 NPs could contribute to a better understanding of NPs’ effect on the development and functions of the placenta and pregnancy outcome. We used primary villous cytotrophoblasts purified from term human placenta, with a wide range of CeO2 NPs concentrations (0.1–101 μg/cm2) and exposure time (24–72 h), to assess trophoblast uptake, toxicity and impact on trophoblast differentiation and endocrine function. We have shown the capacity of both cytotrophoblasts and syncytiotrophoblasts to internalize CeO2 NPs. CeO2 NPs affected trophoblast metabolic activity in a dose and time dependency, induced caspase activation and a LDH release in the absence of oxidative stress. CeO2 NPs decreased the fusion capacity of cytotrophoblasts to form a syncytiotrophoblast and disturbed secretion of the pregnancy hormones hCG, hPL, PlGF, P4 and E2, in accordance with NPs concentration. This is the first study on the impact of CeO2 NPs using human primary trophoblasts that decrypts their toxicity and impact on placental formation and functions.

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Section: Introductionmentioning

confidence: 99%

Uptake of Cerium Dioxide Nanoparticles and Impact on Viability, Differentiation and Functions of Primary Trophoblast Cells from Human Placenta

et al. 2020

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“…To this end, nanotechnology-based therapeutical targeting is instrumental to compensate those deficits. According to the International Union of Pure and Applied Chemistry (IUPAC), nanoparticles (NP) are defined as small particles at the size level of 100 nm or less [ 177 ]. Due to microscopic size, large surface to volume ratio and modifiable surface chemistry, NPs manifest beneficial properties such as longer circulation time, easy penetration into the cell, and effective site-specific targeting [ 178 ].…”

Section: The Use Of Carotenoids In Preclinical Cancer Researchmentioning

confidence: 99%

Carotenoids in Cancer Apoptosis—The Road from Bench to Bedside and Back

Koklesová

Líšková

Samec

et al. 2020

Cancers

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An incidence and mortality of cancer are rapidly growing worldwide, especially due to heterogeneous character of the disease that is associated with irreversible impairment of cellular homeostasis and function. Targeting apoptosis, one of cancer hallmarks, represents a potent cancer treatment strategy. Carotenoids are phytochemicals represented by carotenes, xanthophylls, and derived compounds such as apocarotenoids that demonstrate a broad spectrum of anti-cancer effects involving pro-apoptotic signaling through extrinsic and intrinsic pathways. As demonstrated in preclinical oncology research, the apoptotic modulation is performed at post-genomic levels. Further, carotenoids demonstrate additive/synergistic action in combination with conventional oncostatic agents. In addition, a sensitization of tumor cells to anti-cancer conventional treatment can be achieved by carotenoids. The disadvantage of anti-cancer application of carotenoids is associated with their low solubility and, therefore, poor bioavailability. However, this deficiency can be improved by using nanotechnological approaches, solid dispersions, microemulsions or biofortification that significantly increase the anti-cancer and pro-apoptotic efficacy of carotenoids. Only limited number of studies dealing with apoptotic potential of carotenoids has been published in clinical sphere. Pro-apoptotic effects of carotenoids should be beneficial for individuals at high risk of cancer development. The article considers the utility of carotenoids in the framework of 3P medicine.

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“…Some NPs, called nano-imaging materials, can be used as imaging agents (with diagnostic capability) in ideal imaging systems. The nano-imaging materials commonly used include carbon nanotubes (CNTs), nano-materials with metal ions, rare earth elements, and a new kind of imaging material named aggregation-induced emission (AIE) materials ( 1 ). With the improvement of biomedical imaging technology, nano-imaging materials enable the achievement of early diagnosis and visualization during the treatment process based on their unique optical properties.…”

Section: Introductionmentioning

confidence: 99%

Immunological Effects of Aggregation-Induced Emission Materials

Huang

Zhou

et al. 2020

Front. Immunol.

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Nanotechnology is widely used in the fields of biology and medicine. Some special nanoparticles with good biocompatibility, hydrophilicity, and photostability can be used as ideal systems for biomedical imaging in early diagnosis and treatment of diseases. Among them, aggregation-induced emission materials are new antiaggregation-caused quenching nano-imaging materials, which have advantages in biocompatibility, imaging contrast, and light stability. Meanwhile, heterogeneity of nanoparticles may cause various adverse immune reactions. In response to the above problems, many researchers have modified nano-materials to be multifunctional nano-composites, aiming at combining diagnosis and treatment with simultaneous imaging and targeted therapy and additionally avoiding immune reactions, which is of great potential in imaging-guided therapy. This review discusses the application of aggregation-induced emission materials, and other nano-imaging materials are also mentioned. We hope to provide new ideas and methods for the imaging of nano-materials in diagnosis and treatment.

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Nanoparticles and cancer therapy: Perspectives for application of nanoparticles in the treatment of cancers

Cited by 253 publications

References 117 publications

Uptake of Cerium Dioxide Nanoparticles and Impact on Viability, Differentiation and Functions of Primary Trophoblast Cells from Human Placenta

Uptake of Cerium Dioxide Nanoparticles and Impact on Viability, Differentiation and Functions of Primary Trophoblast Cells from Human Placenta

Carotenoids in Cancer Apoptosis—The Road from Bench to Bedside and Back

Immunological Effects of Aggregation-Induced Emission Materials

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