Nanoparticle‐Shelled Catalytic Bubble Micromotor

Adams, Laura; Lee, Daeyeon; Mei, Yongfeng; Weitz, David A.; Solovev, Alexander A.

doi:10.1002/admi.201901583

Cited by 29 publications

(19 citation statements)

References 35 publications

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“…These micromotors use local energy conversion of fuels from the environment into motion. [95][96][97][98] The propulsion mechanisms included self-electrophoresis, [99][100][101] where an asymmetric fuel decomposition sustains the propulsion of the nanorobot, or bubble propulsion generated by the ejection of gas microbubbles continuously formed inside the catalytic sites of the microrobot engine. [102,103] The first generation of chemically powered micromotors used platinum surfaces as the catalytic engine and peroxide as the fuel.…”

Section: Robotics Engines At Small Scalesmentioning

confidence: 99%

Medical Micro/Nanorobots in Precision Medicine

et al. 2020

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Advances in medical robots promise to improve modern medicine and the quality of life. Miniaturization of these robotic platforms has led to numerous applications that leverages precision medicine. In this review, the current trends of medical micro and nanorobotics for therapy, surgery, diagnosis, and medical imaging are discussed. The use of micro and nanorobots in precision medicine still faces technical, regulatory, and market challenges for their widespread use in clinical settings. Nevertheless, recent translations from proof of concept to in vivo studies demonstrate their potential toward precision medicine.

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Section: Robotics Engines At Small Scalesmentioning

confidence: 99%

Medical Micro/Nanorobots in Precision Medicine

et al. 2020

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“…Subsequently, metallic/catalytic layers can be evaporated on nanoparticle‐shelled bubbles for the demonstration of bubble‐based micromotors in hydrogen peroxide solution (Figure 16c). [ 300 ] Nanoparticle‐shelled microbubbles can withstand drying (SEM image, Figure 16d) and materials evaporation in vacuum (Figure 16e,f). Alternatively, magnetic, catalytic, optical nanoparticles can also be injected along with hydrophobic nanoparticles to form multifunctional bubble shell.…”

Section: Core–shell Structures For Biomedical Applicationsmentioning

confidence: 99%

Micro‐Bio‐Chemo‐Mechanical‐Systems: Micromotors, Microfluidics, and Nanozymes for Biomedical Applications

et al. 2021

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Wireless nano‐/micromotors powered by chemical reactions and/or external fields generate motive forces, perform tasks, and significantly extend short‐range dynamic responses of passive biomedical microcarriers. However, before micromotors can be translated into clinical use, several major problems, including the biocompatibility of materials, the toxicity of chemical fuels, and deep tissue imaging methods, must be solved. Nanomaterials with enzyme‐like characteristics (e.g., catalase, oxidase, peroxidase, superoxide dismutase), that is, nanozymes, can significantly expand the scope of micromotors’ chemical fuels. A convergence of nanozymes, micromotors, and microfluidics can lead to a paradigm shift in the fabrication of multifunctional micromotors in reasonable quantities, encapsulation of desired subsystems, and engineering of FDA‐approved core–shell structures with tuneable biological, physical, chemical, and mechanical properties. Microfluidic methods are used to prepare stable bubbles/microbubbles and capsules integrating ultrasound, optoacoustic, fluorescent, and magnetic resonance imaging modalities. The aim here is to discuss an interdisciplinary approach of three independent emerging topics: micromotors, nanozymes, and microfluidics to creatively: 1) embrace new ideas, 2) think across boundaries, and 3) solve problems whose solutions are beyond the scope of a single discipline toward the development of micro‐bio‐chemo‐mechanical‐systems for diverse bioapplications.

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“…If combined with real-time optoacoustic tracking [71] or magnetic resonance microscopy [72], it is feasible to observe individual microobjects. Recently, multifunctional microbubbles with engineered shells and a gaseous core, fabricated using microfluidic methods, are particularly attractive for biomedical ultrasound imaging and theranostics [73,74].…”

Section: Motion Control Capability Against Complicatedmentioning

confidence: 99%

Requirement and Development of Hydrogel Micromotors towards Biomedical Applications

Lin

Zhu

et al. 2020

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With controllable size, biocompatibility, porosity, injectability, responsivity, diffusion time, reaction, separation, permeation, and release of molecular species, hydrogel microparticles achieve multiple advantages over bulk hydrogels for specific biomedical procedures. Moreover, so far studies mostly concentrate on local responses of hydrogels to chemical and/or external stimuli, which significantly limit the scope of their applications. Tetherless micromotors are autonomous microdevices capable of converting local chemical energy or the energy of external fields into motive forces for self-propelled or externally powered/controlled motion. If hydrogels can be integrated with micromotors, their applicability can be significantly extended and can lead to fully controllable responsive chemomechanical biomicromachines. However, to achieve these challenging goals, biocompatibility, biodegradability, and motive mechanisms of hydrogel micromotors need to be simultaneously integrated. This review summarizes recent achievements in the field of micromotors and hydrogels and proposes next steps required for the development of hydrogel micromotors, which become increasingly important for in vivo and in vitro bioapplications.

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Nanoparticle‐Shelled Catalytic Bubble Micromotor

Cited by 29 publications

References 35 publications

Medical Micro/Nanorobots in Precision Medicine

Medical Micro/Nanorobots in Precision Medicine

Micro‐Bio‐Chemo‐Mechanical‐Systems: Micromotors, Microfluidics, and Nanozymes for Biomedical Applications

Requirement and Development of Hydrogel Micromotors towards Biomedical Applications

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