Nanoparticle-Mediated Remodeling of the Tumor Microenvironment to Enhance Immunotherapy

Musetti, Sara; Huang, Leaf

doi:10.1021/acsnano.8b05893

Cited by 192 publications

(157 citation statements)

References 171 publications

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“…One of the obstacles in the development of immunotherapy is the immunosuppressive nature of TME that largely compromises therapeutic efficacy. Although nanotechnology has been applied to modulate TME for overcoming such a limitation, there is still a large room for further improvement . Very recently, Chen et al have designed a catalytic strategy to relieve tumor hypoxia and modulate immunosuppressive TME for enhancing radiotherapy‐triggered immunotherapy ( Figure ) .…”

Section: Nanocatalytic Medicine For Cancer Therapiesmentioning

confidence: 99%

Nanocatalytic Medicine

2019

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Catalysis and medicine are often considered as two independent research fields with their own respective scientific phenomena. Promoted by recent advances in nanochemistry, large numbers of nanocatalysts, such as nanozymes, photocatalysts, and electrocatalysts, have been applied in vivo to initiate catalytic reactions and modulate biological microenvironments for generating therapeutic effects. The rapid growth of research in biomedical applications of nanocatalysts has led to the concept of “nanocatalytic medicine,” which is expected to promote the further advance of such a subdiscipline in nanomedicine. The high efficiency and selectivity of catalysis that chemists strived to achieve in the past century can be ingeniously translated into high efficacy and mitigated side effects in theranostics by using “nanocatalytic medicine” to steer catalytic reactions for optimized therapeutic outcomes. Here, the rationale behind the construction of nanocatalytic medicine is eludicated based on the essential reaction factors of catalytic reactions (catalysts, energy input, and reactant). Recent advances in this burgeoning field are then comprehensively presented and the mechanisms by which catalytic nanosystems are conferred with theranostic functions are discussed in detail. It is believed that such an emerging catalytic therapeutic modality will play a more important role in the field of nanomedicine.

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Section: Nanocatalytic Medicine For Cancer Therapiesmentioning

confidence: 99%

Nanocatalytic Medicine

2019

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“…[3,18,196] Regulating the TME by interfering the undesired cells or molecules can be a practical method to promote the anticancer immunity. [3,18,196] Regulating the TME by interfering the undesired cells or molecules can be a practical method to promote the anticancer immunity.…”

Section: Doi: 101002/advs201900101mentioning

confidence: 99%

“…Until recently, many immunotherapies targeting TME have gained intriguing results. [18] In some cases, biomimetic nanoparticle platforms are designed to perform intrinsic regulatory effect toward immunosuppressive cells. For example, nanoparticles with targeting ligands are capable of increasing drug accumulation in TME and even increasing internalization by specific immune cell type, thereby overcoming potential systemic hazard and enhancing drug efficiency.…”

Section: Doi: 101002/advs201900101mentioning

confidence: 99%

Immunomodulatory Nanosystems

et al. 2019

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Immunotherapy has emerged as an effective strategy for the prevention and treatment of a variety of diseases, including cancer, infectious diseases, inflammatory diseases, and autoimmune diseases. Immunomodulatory nanosystems can readily improve the therapeutic effects and simultaneously overcome many obstacles facing the treatment method, such as inadequate immune stimulation, off‐target side effects, and bioactivity loss of immune agents during circulation. In recent years, researchers have continuously developed nanomaterials with new structures, properties, and functions. This Review provides the most recent advances of nanotechnology for immunostimulation and immunosuppression. In cancer immunotherapy, nanosystems play an essential role in immune cell activation and tumor microenvironment modulation, as well as combination with other antitumor approaches. In infectious diseases, many encouraging outcomes from using nanomaterial vaccines against viral and bacterial infections have been reported. In addition, nanoparticles also potentiate the effects of immunosuppressive immune cells for the treatment of inflammatory and autoimmune diseases. Finally, the challenges and prospects of applying nanotechnology to modulate immunotherapy are discussed.

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“…Considering the increasing role of cancer immunotherapy, not surprisingly, most of these new targets belong to the immune system. As extensively reviewed, many approaches have been investigated to ameliorate the impact of cancer immunotherapy through the use of nanomedicine [14,136,137]. Here we focus on those that directly modulate the activity of particular cellular mediators, such as tumor-associated macrophages (TAMs), myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Treg) [138].…”

Section: Nanoimmunology and New Targetsmentioning

confidence: 99%

Thirty Years of Cancer Nanomedicine: Success, Frustration, and Hope

Salvioni

Rizzuto

Bertolini

et al. 2019

Cancers

148

138

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Starting with the enhanced permeability and retention (EPR) effect discovery, nanomedicine has gained a crucial role in cancer treatment. The advances in the field have led to the approval of nanodrugs with improved safety profile and still inspire the ongoing investigations. However, several restrictions, such as high manufacturing costs, technical challenges, and effectiveness below expectations, raised skeptical opinions within the scientific community about the clinical relevance of nanomedicine. In this review, we aim to give an overall vision of the current hurdles encountered by nanotherapeutics along with their design, development, and translation, and we offer a prospective view on possible strategies to overcome such limitations.

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Nanoparticle-Mediated Remodeling of the Tumor Microenvironment to Enhance Immunotherapy

Cited by 192 publications

References 171 publications

Nanocatalytic Medicine

Nanocatalytic Medicine

Immunomodulatory Nanosystems

Thirty Years of Cancer Nanomedicine: Success, Frustration, and Hope

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