Nanoparticle-Mediated Nonviral DNA Delivery for Effective Inhibition of Influenza a Viruses in Cells

Левина, А. С.; Репкова, М. Н.; Мазуркова, Н. А.; Зарытова, В. Ф.

doi:10.1109/tnano.2016.2516561

Cited by 31 publications

(19 citation statements)

References 26 publications

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“…Nanoparticulate delivery of RNAi therapy has been frequently adopted for treating influenza infections. On this front, chitosan nanoparticles [ 155 ], calcium phosphate nanoparticles [ 156 ], and titanium oxide nanocomposites [ 157 ] have all been leveraged for gene silencing and inhibiting influenza viral replication. Titanium oxide nanocomposites in particular have been used to deliver deoxyribozymes, which are DNA enzymes that can be used to cleave viral RNA and have been shown to inhibit H5N1 viral titers by roughly 2650-fold in vitro [ 158 ].…”

Section: Nanotechnology Interventionsmentioning

confidence: 99%

Nanotechnology for virus treatment

et al. 2021

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Section: Nanotechnology Interventionsmentioning

confidence: 99%

Nanotechnology for virus treatment

et al. 2021

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“…In addition, the major requirements including cellular entry through the blood-brain barrier and blood-air barrier, tenability and targeted control discharge are feasible with nanomaterials, thus qualifying these materials as potential novel candidates for use in biomedical therapy [ 28 , 29 , 30 ] Nanoparticles have been widely used in antiviral therapy over the last few decades, owing to the development of surface functionalization strategies [ 45 ]. For example, Ag [ 46 ], Au [ 47 ], TiO 2 [ 48 ], SiO 2 [ 49 ], CeO 2 [ 50 ] and CuCl 2 [ 51 ] nanoparticles have been employed against different viruses including hepatitis B virus (HBV) [ 46 ], H3N2 and H1N1 [ 52 ], HIV-1 [ 53 ], herpes simplex virus (HSV) [ 54 ], vesicular stomatitis [ 55 ], foot-and-mouth disease [ 47 ] and dengue virus type-2 [ 51 ]. Recently, Sportelli et al (2020) stated that researchers need to focus on the development of nanomaterial-based technological solutions to fight COVID-19 [ 56 ].…”

Section: Introductionmentioning

confidence: 99%

Antiviral Potential of Nanoparticles—Can Nanoparticles Fight Against Coronaviruses?

et al. 2020

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Infectious diseases account for more than 20% of global mortality and viruses are responsible for about one-third of these deaths. Highly infectious viral diseases such as severe acute respiratory (SARS), Middle East respiratory syndrome (MERS) and coronavirus disease (COVID-19) are emerging more frequently and their worldwide spread poses a serious threat to human health and the global economy. The current COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). As of 27 July 2020, SARS-CoV-2 has infected over 16 million people and led to the death of more than 652,434 individuals as on 27 July 2020 while also causing significant economic losses. To date, there are no vaccines or specific antiviral drugs to prevent or treat COVID-19. Hence, it is necessary to accelerate the development of antiviral drugs and vaccines to help mitigate this pandemic. Non-Conventional antiviral agents must also be considered and exploited. In this regard, nanoparticles can be used as antiviral agents for the treatment of various viral infections. The use of nanoparticles provides an interesting opportunity for the development of novel antiviral therapies with a low probability of developing drug resistance compared to conventional chemical-based antiviral therapies. In this review, we first discuss viral mechanisms of entry into host cells and then we detail the major and important types of nanomaterials that could be used as antiviral agents. These nanomaterials include silver, gold, quantum dots, organic nanoparticles, liposomes, dendrimers and polymers. Further, we consider antiviral mechanisms, the effects of nanoparticles on coronaviruses and therapeutic approaches of nanoparticles. Finally, we provide our perspective on the future of nanoparticles in the fight against viral infections.

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“…Control samples containing random DNA sequences, unbound DNA fragments in the presence of nanoparticles, and naked nanoparticles showed minor antiviral effects. 167…”

Section: Antiviral Nanotherapeuticsmentioning

confidence: 99%

The role of nanotechnology in the treatment of viral infections

Singh

Kruger

Maguire

et al. 2017

Therapeutic Advances in Infection

246

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Infectious diseases are the leading cause of mortality worldwide, with viruses in particular making global impact on healthcare and socioeconomic development. In addition, the rapid development of drug resistance to currently available therapies and adverse side effects due to prolonged use is a serious public health concern. The development of novel treatment strategies is therefore required. The interaction of nanostructures with microorganisms is fast-revolutionizing the biomedical field by offering advantages in both diagnostic and therapeutic applications. Nanoparticles offer unique physical properties that have associated benefits for drug delivery. These are predominantly due to the particle size (which affects bioavailability and circulation time), large surface area to volume ratio (enhanced solubility compared to larger particles), tunable surface charge of the particle with the possibility of encapsulation, and large drug payloads that can be accommodated. These properties, which are unlike bulk materials of the same compositions, make nanoparticulate drug delivery systems ideal candidates to explore in order to achieve and/or improve therapeutic effects. This review presents a broad overview of the application of nanosized materials for the treatment of common viral infections.

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Nanoparticle-Mediated Nonviral DNA Delivery for Effective Inhibition of Influenza a Viruses in Cells

Cited by 31 publications

References 26 publications

Nanotechnology for virus treatment

Nanotechnology for virus treatment

Antiviral Potential of Nanoparticles—Can Nanoparticles Fight Against Coronaviruses?

The role of nanotechnology in the treatment of viral infections

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