Nanoparticle-mediated local depletion of tumour-associated platelets disrupts vascular barriers and augments drug accumulation in tumours

Li, Suping; Zhang, Yinlong; Wang, Jing; Zhao, Ying; Ji, Tianjiao; Zhao, Xiao; Ding, Yanping; Zhao, Xin; Zhao, Ruifang; Li, Feng; Xiao, Yang; Liu, Shaoli; Liu, Zhaofei; Lai, Jianhao; Whittaker, Andrew K.; Anderson, Gregory J.; Wei, Jingyan; Nie, Guangjun

doi:10.1038/s41551-017-0115-8

Cited by 139 publications

(109 citation statements)

References 45 publications

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“…For example, nanoparticles can be engineered for targeting delivery of drugs to tumor cells depending on the immune environment. [159] Depletion of platelets created openings in the tumor vessels for easier entrance of the drug-loaded core nanoparticles. [158] Intravenous injection of the neutrophil-based nanoparticle formulation delivered PTX into inflamed brain after surgery and effectively prevented glioma recurrence.…”

Section: Combination Of Immunotherapy and Traditional Managementsmentioning

confidence: 99%

Immunomodulatory Nanosystems

et al. 2019

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Immunotherapy has emerged as an effective strategy for the prevention and treatment of a variety of diseases, including cancer, infectious diseases, inflammatory diseases, and autoimmune diseases. Immunomodulatory nanosystems can readily improve the therapeutic effects and simultaneously overcome many obstacles facing the treatment method, such as inadequate immune stimulation, off‐target side effects, and bioactivity loss of immune agents during circulation. In recent years, researchers have continuously developed nanomaterials with new structures, properties, and functions. This Review provides the most recent advances of nanotechnology for immunostimulation and immunosuppression. In cancer immunotherapy, nanosystems play an essential role in immune cell activation and tumor microenvironment modulation, as well as combination with other antitumor approaches. In infectious diseases, many encouraging outcomes from using nanomaterial vaccines against viral and bacterial infections have been reported. In addition, nanoparticles also potentiate the effects of immunosuppressive immune cells for the treatment of inflammatory and autoimmune diseases. Finally, the challenges and prospects of applying nanotechnology to modulate immunotherapy are discussed.

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Section: Combination Of Immunotherapy and Traditional Managementsmentioning

confidence: 99%

Immunomodulatory Nanosystems

et al. 2019

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“…In addition to the extensive presence of stromal cells and the ECM, Nie and co‐workers designed a polymer–lipid–peptide nanoparticles for delivering the antiplatelet antibody R300 and the chemotherapeutic agent DOX . This nanoparticle released the antibody R300 upon cleavage of the lipid–peptide shell and locally deplete tumor‐associated platelets, thereby enhancing vascular permeability and augmenting the accumulation of the nanoparticles in tumors.…”

Section: Remodeling Of Tumor Stromal Microenvironmentsmentioning

confidence: 99%

Rational Design of Nanoparticles with Deep Tumor Penetration for Effective Treatment of Tumor Metastasis

Zhang

Wang

Tan

et al. 2018

Adv Funct Materials

118

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The limited penetration of nanoparticles in primary tumors and metastases remains a great challenge for effective treatment of tumor metastasis. This review outlines the current approaches and summarizes the rational design of nanoparticles with deep tumor penetration capacity for anti-metastasis treatment. There are two ways to achieve better tumor penetration; through rational regulation of the physicochemical properties of nanoparticles and through remodeling of the tumor microenvironment, including the tumor vasculature and stromal environment. Moreover, biomimetic strategies that integrate the advantages of nanoparticles and metastasis-homing molecules during cancer cell metastasis are discussed. These efforts have led to promising results in facilitating intratumoral permeation of various nanoparticles to enhance antitumor effects. The considerations and some feasible future directions for deep tumor penetration strategies are proposed to improve tumor metastasis therapies.

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“…These micelles could be used as the platforms for cargos delivery. [80] In this multifunctional nanocarrier, the lipid-peptide shell could be cleaved by metalloproteinase 2 (MMP2) which overexpressed in tumor vascular endothelia and stroma. [75,76] The charged density of proteins cytochrome c (CytC) and IgG were temporarily increased by conjugating with charge-conversional moieties, citraconic acid amide (Cit) or cis-aconitic acid (Aco).…”

Section: Wwwadvmatde Wwwadvancedsciencenewscommentioning

confidence: 99%

Rational Design of Nanocarriers for Intracellular Protein Delivery

et al. 2019

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Protein/antibody therapeutics have exhibited the advantages of high specificity and activity even at an extremely low concentration compared to small molecule drugs. However, they are accompanied by unfavorable physicochemical properties such as fragile tertiary structure, large molecular size, and poor penetration of the membrane, and thus the clinical use of protein drugs is hindered by inefficient delivery of proteins into the host cells. To overcome the challenges associated with protein therapeutics and enhance their biopharmaceutical applications, various protein‐loaded nanocarriers with desired functions, such as lipid nanocapsules, polymeric nanoparticles, inorganic nanoparticles, and peptides, are developed. In this review, the different strategies for intracellular delivery of proteins are comprehensively summarized. Their designed routes, mechanisms of action, and potential therapeutics in live cells or in vivo are discussed in detail. Furthermore, the perspective on the new generation of delivery systems toward the emerging area of protein‐based therapeutics is presented as well.

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Nanoparticle-mediated local depletion of tumour-associated platelets disrupts vascular barriers and augments drug accumulation in tumours

Cited by 139 publications

References 45 publications

Immunomodulatory Nanosystems

Immunomodulatory Nanosystems

Rational Design of Nanoparticles with Deep Tumor Penetration for Effective Treatment of Tumor Metastasis

Rational Design of Nanocarriers for Intracellular Protein Delivery

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