Abstract:Nanoparticle-mediated histotripsy (NMH) is a targeted ablation method using perfluorocarbon-filled nanoparticles to generate bubble-clouds at pressure levels (9–12 MPa) significantly below the histotripsy intrinsic threshold (>25 MPa). Prior studies have also shown a significant reduction in ablation efficiency compared to conventional histotripsy, likely from reduced bubble expansion and bubble-cloud density. Here, we investigate the bubble-cloud characteristics and ablation efficiency for NMH using dual-f… Show more
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