Nanoparticle-laden contact lens for controlled release of vancomycin with enhanced antibiotic efficacy

Tong, Woei Yenn; Tan, Wen-Nee; Azizi, Muhammad Afif Kamarul; Leong, Chean Ring; Azab, Islam H. El; Lim, Jun Wei; Mahmoud, M.H.; Dailin, Daniel Joe; Ibrahim, Mohamed M.; Chuah, Lai Fatt

doi:10.1016/j.chemosphere.2023.139492

Cited by 7 publications

(2 citation statements)

References 43 publications

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“…Based on the results for nanoparticles, an average hydrodynamic diameter of 87 ± 2 nm with a polydispersion index (PDI) of 0.32 was determined as shown in Table 1 . The research suggests that nanoparticles with sizes between 10 and 200 nm have a higher chance of having increased permeability [ 27 ]. Moreover, particles in the 100–200 nm hydrodynamic diameter range are large enough to be retained in the intestinal tract.…”

Section: Resultsmentioning

confidence: 99%

Nanoparticles of Thiolated Xanthan Gum for the Oral Delivery of Miconazole Nitrate: In Vitro and In Vivo Evaluation

Namazi,

Alrbyawi,

Alanezi

et al. 2024

Pharmaceutics

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The objective of this research was to develop a mucoadhesive delivery system that improves permeation for the administration of poorly absorbed oral medications. Thiolation of xanthan gum (XGM) was carried out by esterification with mercaptobutyric acid. Fourier-transformed infrared spectroscopy was used to confirm thiol-derivatization. Using Ellman’s technique, it was revealed that the xanthan-mercaptobutyric acid conjugate had 4.7 mM of thiol groups in 2 mg/mL of polymeric solution. Using mucosa of sheep intestine, the mucoadhesive properties of XGM and thiolated xanthan gum (TXGM) nanoparticles were investigated and we found that TXGM had a longer bioadhesion time than XGM. The disulfide link that forms between mucus and thiolated XGM explains why it has better mucoadhesive properties than XGM. A study on in vitro miconazole (MCZ) release using phosphate buffer (pH 6.8) found that TXGM nanoparticles released MCZ more steadily than MCZ dispersion did. A 1-fold increase in the permeation of MCZ was observed from nanoparticles using albino rat intestine compared to MCZ. Albino rats were used to test the pharmacokinetics of MCZ, and the results showed a 4.5-fold increase in bioavailability. In conclusion, the thiolation of XGM enhances its bioavailability, controlled release of MCZ for a long period of time, and mucoadhesive activity.

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Section: Resultsmentioning

confidence: 99%

Nanoparticles of Thiolated Xanthan Gum for the Oral Delivery of Miconazole Nitrate: In Vitro and In Vivo Evaluation

Namazi,

Alrbyawi,

Alanezi

et al. 2024

Pharmaceutics

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“…Tong et al suggested the use of polyvinyl alcohol (PVA) nanoparticles to deliver vancomycin in silicone hydrogel contact lenses. [80] Compared to previous methods for consuming vancomycin, the newly developed contact lens not only minimizes systemic exposure but also removes the nuisance of hourly topical applications. Findings from the study indicate that nano-encapsulation resulted in the gradual release of vancomycin for 48 days.…”

Section: Antibiotic Deliverymentioning

confidence: 99%

Smart molecules in ophthalmology: Hydrogels as responsive systems for ophthalmic applications

Kulbay,

Wu,

Truong

et al. 2024

Smart Molecules

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This comprehensive review delves into a unique intersection of hydrogels as smart molecules and their transformative applications in ophthalmology. Beginning with the foundational definition, properties, and classification of hydrogels, the review explores their synthesis and responsive capabilities. Specific applications examined encompass topical drug delivery, contact lenses, intravitreal drug delivery, ocular adhesives, vitreous substitutes, and cell‐based therapy. A methodical analysis, including an overview of relevant ocular structures and a comparative evaluation of hydrogel‐based solutions against traditional treatments, is conducted. Additionally, potential constraints, translation challenges, knowledge gaps, and research areas are identified. Our methodical approach, guided by an extensive literature review from 2017 to 2023, illuminates the unprecedented opportunities offered by hydrogels, along with pinpointing areas for further inquiry to facilitate their transition into clinical practice.

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Rational design of antibiotic-free antimicrobial contact lenses: Trade-offs between antimicrobial performance and biocompatibility

Zhu,

Guan,

Tian

et al. 2024

Biomaterials Advances

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Nanoparticle-laden contact lens for controlled release of vancomycin with enhanced antibiotic efficacy

Cited by 7 publications

References 43 publications

Nanoparticles of Thiolated Xanthan Gum for the Oral Delivery of Miconazole Nitrate: In Vitro and In Vivo Evaluation

Nanoparticles of Thiolated Xanthan Gum for the Oral Delivery of Miconazole Nitrate: In Vitro and In Vivo Evaluation

Smart molecules in ophthalmology: Hydrogels as responsive systems for ophthalmic applications

Rational design of antibiotic-free antimicrobial contact lenses: Trade-offs between antimicrobial performance and biocompatibility

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