Nanoparticle-Integrated Hydrogels as Multifunctional Composite Materials for Biomedical Applications

Biondi, Marco; Borzacchiello, Assunta; Mayol, Laura; Ambrosio, Luigi

doi:10.3390/gels1020162

Cited by 107 publications

(71 citation statements)

References 88 publications

(91 reference statements)

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“…Composites, combining ceramics and polymers, have emerged as potential biomaterials for the management of bone defects [6]. The osteoconductive/osteoinductive, biocompatibility and bioactivity properties of nanoHA materials [7,28] combined with the injectability, biocompatibility and biodegradation properties of Alg polymers [29,30] can improve the physic-chemical and cell adhesion/tissue development of the attained composites, enhancing bone tissue regeneration [31][32][33]. However, these properties could be dependent on the amount of ceramic nanoparticles used within the polymer-based composite, as observed by other authors [21][22][23].…”

Section: Discussionmentioning

confidence: 99%

Alginate-nanohydroxyapatite hydrogel system: Optimizing the formulation for enhanced bone regeneration

Barros

Ferraz

Azeredo

et al. 2019

Materials Science and Engineering: C

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A B S T R A C TCeramic/polymer-based biocomposites have emerged as potential biomaterials to fill, replace, repair or regenerate injured or diseased bone, due to their outstanding features in terms of biocompatibility, bioactivity, injectability, and biodegradability. However, these properties can be dependent on the amount of ceramic component present in the polymer-based composite. Therefore, in the present study, the influence of nanohydroxyapatite content (30 to 70 wt%) on alginate-based hydrogels was studied in order to evaluate the best formulation for maximizing bone tissue regeneration. The composite system was characterized in terms of physic-chemical properties and biological response, with in vitro cytocompatibility assessment with human osteoblastic cells and ex vivo functional evaluation in embryonic chick segmental bone defects. The main morphological characteristics of the alginate network were not affected by the addition of nanohydroxyapatite. However, physic-chemical features, like water-swelling rate, stability at extreme pH values, apatite formation, and Ca 2+ release were nanoHA dose-dependent. Within in vitro cytocompatibility assays it was observed that hydrogels with nanoHA 30% content enhanced osteoblastic cells proliferation and expression of osteogenic transcription factors, while those with higher concentrations (50 and 70%) decreased the osteogenic cell response. Ex vivo data underlined the in vitro findings, revealing an enhanced collagenous deposition, trabecular bone formation and matrix mineralization with Alg-nanoHA30 composition, while compositions with higher nanoHA content induced a diminished bone tissue response.The outcomes of this study indicate that nanohydroxyapatite concentration plays a major role in physicchemical properties and biological response of the composite system and the optimization of the components ratio must be met to maximize bone tissue regeneration.

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Section: Discussionmentioning

confidence: 99%

Alginate-nanohydroxyapatite hydrogel system: Optimizing the formulation for enhanced bone regeneration

Barros

Ferraz

Azeredo

et al. 2019

Materials Science and Engineering: C

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“…Subsequently, not exclusively did Car–Go increase the cell attachment; however it additionally empowered bone mineralization capacity of cells . When HAP‐including vesicles were discharged from the osteoblast cells, ions will be stored and bone mimetic crystallites will develop . Graphene and HAP nanoparticles can self‐assemble into 3D nanocomposite hydrogel in view of colloidal chemistry amalgamation, utilizing fluid suspensions of GO nanosheets and citrate‐stabilized HAP nanoparticles .…”

Section: Biomedical Applicationsmentioning

confidence: 99%

“…It was also found to show improved affinity of cells on the developed graphene–HAP nanocomposite hydrogel. rGO sheets and HAP microparticles can attach with each other through electrostatic communications and by hydrogen‐holding . The positively charged calcium functionalities on the surface of HAP microparticles can be immobilized on the negatively charged hydroxyl and carboxyl gatherings on the surface of rGO sheets through electrostatic interactions.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Graphene and Graphene‐Based Materials in Biomedical Science

Swetha

Manisha

Prasad

2018

Part & Part Syst Charact

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Graphene and its composite materials are very important in many disciplines of science and have been used enormously by researchers since their discovery in 2004. These are a new group of compounds, and are also wonderful model systems for quantum behavior studies. Their properties like exceptional conductivity, biocompatibility, surface area, mechanical strength, and thermal properties make them rising stars in the scientific community. Graphene and its composite compounds are utilized widely in different medical applications, for example, biosensing of biological compounds responsible for disease development, bioimaging of various cells, tissues, microorganisms, animal models, etc. In addition, they are used for enhancing and supporting the stem cell differentiation, i.e., regenerative medicine for regeneration studies of various human organs, tissue engineering in biology for the development of carrier materials, as well as in bone reformation. This review focuses on the modification procedure involved in the fabrication of graphene‐based biomaterials for various applications and recent developments in research related to graphene and graphene‐based materials in biosensing, optical sensing, gas sensing, drug, gene, protein delivery, tissue engineering, and bioimaging. In addition, the potential toxicological effects of graphene‐based biomaterials are discussed.

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“…The application of hydrogel may be better if a nanomaterials is inserted in the hydrogel's matrix. Therefore, current studies in hydrogel have led to the development of NCHs [48]. Nanoparticles, containing organic/polymeric and inorganic (such as hydroxyapatite, clay, graphene and metallic nanoparticles) can be used as fillers to reinforce the hydrogel matrix [49].…”

Section: Improvement Of Hydrogel Properties With Nanoparticlesmentioning

confidence: 99%

Nanocomposite hydrogels for cartilage tissue engineering: a review

Asadi

Alizadeh

Salehi

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

101

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The loss of cartilaginous tissues is an important challenge to orthopaedic surgeons. Injury to cartilage tissue due to its properties is along with movement difficulties. Tissue engineering is a developing field that can be used for regeneration or replacement of damaged tissues. In this field, an appropriate scaffold that support the recruitment, adhesion, proliferation and differentiation of cells is necessary. Hydrogels recently considered as materials that resemble the extracellular matrix (ECM) and efficiently replace defective tissues, but they have limited mechanical strength. So nanomaterials are embedded in the hydrogel's matrix to improve their properties. Nanoparticles, such as organic/polymeric and inorganic (hydroxyapatite, clay, graphene and metallic nanoparticles), can be used as fillers to reinforce the hydrogel matrix. Utilizing those nanocomposites could help in better performance of hydrogels applicable in cartilage regeneration practices. This review presents some of nanocomposite hydrogel (NCH) systems that used in cartilage tissue engineering.

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Nanoparticle-Integrated Hydrogels as Multifunctional Composite Materials for Biomedical Applications

Cited by 107 publications

References 88 publications

Alginate-nanohydroxyapatite hydrogel system: Optimizing the formulation for enhanced bone regeneration

Alginate-nanohydroxyapatite hydrogel system: Optimizing the formulation for enhanced bone regeneration

Graphene and Graphene‐Based Materials in Biomedical Science

Nanocomposite hydrogels for cartilage tissue engineering: a review

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