Nanoparticle inhalation augments particle-dependent systemic microvascular dysfunction

Nurkiewicz, Timothy R.; Porter, Dale W.; Hubbs, Ann F.; Cumpston, Jared L.; Chen, Bean T.; Frazer, David G.; Castranova, Vincent

doi:10.1186/1743-8977-5-1

Cited by 214 publications

(215 citation statements)

References 46 publications

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“…The small size of ENP ensures that a high proportion inhaled from the air reach and deposit in the deep lungs. In consequence, they may pass directly through the cell membrane with the possibility of interfering with important cell functions (Donaldson et al 1998;Donaldson et al 2000;Kreyling et al 2006;Limbach et al 2007;Nurkiewicz et al 2008). It was also stated that ENP can pass alveoli membranes and might enter blood streams, where an interference of blood coagulation may be possible, and, therefore, hindering transportation and enrichment, in vitally important organs is possible (Rothen-Rutishauser et al 2005.…”

Section: Introductionmentioning

confidence: 99%

Size-fractionated characterization and quantification of nanoparticle release rates from a consumer spray product containing engineered nanoparticles

Lorenz²,

et al. 2009

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This study describes methods developed for reliable quantification of size-and element-specific release of engineered nanoparticles (ENP) from consumer spray products. A modified glove box setup was designed to allow controlled spray experiments in a particle-minimized environment. Time dependence of the particle size distribution in a size range of 10-500 nm and ENP release rates were studied using a scanning mobility particle sizer (SMPS). In parallel, the aerosol was transferred to a size-calibrated electrostatic TEM sampler. The deposited particles were investigated using electron microscopy techniques in combination with image processing software. This approach enables the chemical and morphological characterization as well as quantification of released nanoparticles from a spray product. The differentiation of solid ENP from the released nano-sized droplets was achieved by applying a thermo-desorbing unit. After optimization, the setup was applied to investigate different spray situations using both pump and gas propellant spray dispensers for a commercially available water-based nano-silver spray. The pump spray situation showed no measurable nanoparticle release, 123J Nanopart Res (2010) 12:2481-2494 DOI 10.1007 whereas in the case of the gas spray, a significant release was observed. From the results it can be assumed that the homogeneously distributed ENP from the original dispersion grow in size and change morphology during and after the spray process but still exist as nanometer particles of size \100 nm. Furthermore, it seems that the release of ENP correlates with the generated aerosol droplet size distribution produced by the spray vessel type used. This is the first study presenting results concerning the release of ENP from spray products.

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Section: Introductionmentioning

confidence: 99%

Size-fractionated characterization and quantification of nanoparticle release rates from a consumer spray product containing engineered nanoparticles

Lorenz²,

et al. 2009

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“…This response is similar to the type of pathophysiological microvascular consequences that occur in chronic diseases such as diabetes, hypertension, and heart failure. 86 In rats, inhaled Fe 2 O 3…”

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confidence: 99%

Perturbation of physiological systems by nanoparticles

et al. 2014

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Nanotechnology is having a tremendous impact on our society. However, societal concerns about human safety under nanoparticle exposure may derail the broad application of this promising technology. Nanoparticles may enter the human body via various routes, including respiratory pathways, the digestive tract, skin contact, intravenous injection, and implantation. After absorption, nanoparticles are carried to distal organs by the bloodstream and the lymphatic system. During this process, they interact with biological molecules and perturb physiological systems. Although some ingested or absorbed nanoparticles are eliminated, others remain in the body for a long time. The human body is composed of multiple systems that work together to maintain physiological homeostasis. The unexpected invasion of these systems by nanoparticles disturbs normal cell signaling, impairs cell and organ functions, and may even cause pathological disorders. This review examines the comprehensive health risks of exposure to nanoparticles by discussing how nanoparticles perturb various physiological systems as revealed by animal studies. The potential toxicity of nanoparticles to each physiological system and the implications of disrupting the balance among systems are emphasized.

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“…Inhalation of nano TiO 2 in a rat model has been shown to decrease the dilatory responsiveness of microvessels in the shoulder muscle and the heart (Nurkiewicz et al, 2008;LeBlanc et al, 2009). In the present study, inhalation of a spray product containing nano TiO 2 failed to alter the responsiveness of the tail artery to either constrictor or dilatory agents.…”

Section: Discussionmentioning

confidence: 36%

Pulmonary and cardiovascular responses of rats to inhalation of a commercial antimicrobial spray containing titanium dioxide nanoparticles

McKinney

Jackson

Sager

et al. 2012

Inhalation Toxicology

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Our laboratory has previously demonstrated that application of an antimicrobial spray product containing titanium dioxide (TiO 2 ) generates an aerosol of titanium dioxide in the breathing zone of the applicator. The present report describes the design of an automated spray system and the characterization of the aerosol delivered to a whole body inhalation chamber. This system produced stable airborne levels of TiO 2 particles with a median count size diameter of 110 nm. Rats were exposed to 314 mg/m 3 min (low dose), 826 mg/m 3 min (medium dose), and 3638 mg/m 3 min (high dose) of TiO 2 under the following conditions: 2.62 mg/m 3 for 2 h, 1.72 mg/m 3 4 h/day for 2 days, and 3.79 mg/m 3 4 h/day for 4 days, respectively. Pulmonary (breathing rate, specific airway resistance, inflammation, and lung damage) and cardiovascular (the responsiveness of the tail artery to constrictor or dilatory agents) endpoints were monitored 24 h post-exposure. No significant pulmonary or cardiovascular changes were noted at low and middle dose levels. However, the high dose caused significant increases in breathing rate, pulmonary inflammation, and lung cell injury. Results suggest that occasional consumer use of this antimicrobial spray product should not be a hazard. However, extended exposure of workers routinely applying this product to surfaces should be avoided. During application, care should be taken to minimize exposure by working under well ventilated conditions and by employing respiratory protection as needed. It would be prudent to avoid exposure to children or those with pre-existing respiratory disease.

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Nanoparticle inhalation augments particle-dependent systemic microvascular dysfunction

Cited by 214 publications

References 46 publications

Size-fractionated characterization and quantification of nanoparticle release rates from a consumer spray product containing engineered nanoparticles

Size-fractionated characterization and quantification of nanoparticle release rates from a consumer spray product containing engineered nanoparticles

Perturbation of physiological systems by nanoparticles

Pulmonary and cardiovascular responses of rats to inhalation of a commercial antimicrobial spray containing titanium dioxide nanoparticles

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