Nanoparticle-Induced m6A RNA Modification: Detection Methods, Mechanisms and Applications

Abstract

With the increasing application of nanoparticles (NPs) in medical and consumer applications, it is necessary to ensure their safety. As m6A (N6-methyladenosine) RNA modification is one of the most prevalent RNA modifications involved in many diseases and essential biological processes, the relationship between nanoparticles and m6A RNA modification for the modulation of these events has attracted substantial research interest. However, there is limited knowledge regarding the relationship between nanoparticles and m6A RNA modification, but evidence is beginning to emerge. Therefore, a summary of these aspects from current research on nanoparticle-induced m6A RNA modification is timely and significant. In this review, we highlight the roles of m6A RNA modification in the bioimpacts of nanoparticles and thus elaborate on the mechanisms of nanoparticle-induced m6A RNA modification. We also summarize the dynamic regulation and biofunctions of m6A RNA modification. Moreover, we emphasize recent advances in the application perspective of nanoparticle-induced m6A RNA modification in medication and toxicity of nanoparticles to provide a potential method to facilitate the design of nanoparticles by deliberately tuning m6A RNA modification.

Systematic Review: Efek Nanoplastik terhadap Metilasi DNA pada Manusia

“…Melalui kejadian metilasi ini akan mengganggu pengartian/transkripsi DNA sehingga dapat menyebabkan dampak negatif pada kesehatan manusia. Wang, dkk (2022) menyebutkan bahwa metilasi DNA dapat menyebabkan obesitas, malformasi otak, dan retardasi pada pertumbuhan (Wang et al, 2022). S. Elisabeth, dkk (2022) menambahkan bahwa adanya metilasi DNA dan ekspresi gen melalui pengikatan reseptor estrogen klasik (ER) terbukti memiliki kaitan erat dengan pertumbuhan sel induk kanker (Gruber et al, 2022) (Management, 2021).…”