Nanoparticle-Hydrogel Composite Drug Delivery System for Potential Ocular Applications

Hsu, Xuan Ling; Wu, Lien Chen; Hsieh, Jui Yang; Huang, Yi You

doi:10.3390/polym13040642

Cited by 27 publications

(18 citation statements)

References 67 publications

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“…An in vitro drug release test was conducted by evaluating the release profile of BSA from the HP hydrogel. BSA was used as a model drug for its similar protein quaternary structure, molecular weight, and hydrodynamic radiuses to ranibizumab. − Figure A shows the cumulative drug release profile. In the fourth hour, around 20% of drugs were released at a relatively fast rate.…”

Section: Resultsmentioning

confidence: 99%

Biomimetic, Injectable, and Self-Healing Hydrogels with Sustained Release of Ranibizumab to Treat Retinal Neovascularization

Duan

Mei

et al. 2023

ACS Appl. Mater. Interfaces

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Retinal neovascularization (RNV) is a typical feature of ischemic retinal diseases that can lead to traction retinal detachment and even blindness in patients, in which the vascular endothelial cell growth factor (VEGF) plays a pivotal role. However, most anti-VEGF drugs currently used for treating RNV, such as ranibizumab, need frequent and repeated intravitreal injections due to their short intravitreal half-life, which increases the incidence of complications. Herein, a hydrogel intravitreal drug delivery system (DDS) is prepared by a dynamic Schiff base reaction between aminated hyaluronic acid and aldehyde-functionalized Pluronic 127 for sustained release of ranibizumab. The prepared hydrogel system named HP@Ran exhibits excellent injectability, self-healing ability, structural stability, cytocompatibility, and blood compatibility. According to an in vitro drug release study, the hydrogel system continuously releases the model drug bovine serum albumin for more than 56 days. Importantly, in an in vivo rabbit persistent RNV model, the HP@Ran hydrogel system continuously releases pharmacologically active ranibizumab for more than 7 weeks and also exhibits superior anti-angiogenic efficacy over ranibizumab treatment by decreasing vascular leakage and neovascularization at 12 weeks. Thus, the developed HP@Ran hydrogel system possesses great potential for intravitreal DDS for the treatment of RNV.

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Section: Resultsmentioning

confidence: 99%

Biomimetic, Injectable, and Self-Healing Hydrogels with Sustained Release of Ranibizumab to Treat Retinal Neovascularization

Duan

Mei

et al. 2023

ACS Appl. Mater. Interfaces

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“…While showing promising results in terms of stability and drug release, the hydrogel required chemical cross-linking before administration. This led to a more stable system, but highly viscous cross-linked hydrogels cannot be injected and must be implanted, leading to a more invasive approach [ 86 ]. Finally, injectable thermosensitive hydrogels loaded with chitosan-based NPs were investigated by Taheri et al This system required the addition of the semi-synthetic cellulose derivative HPMC to reach the desired gelation point and higher concentrations of poloxamer 407 compared to our system [ 87 ].…”

Section: Discussionmentioning

confidence: 99%

Optimization of an Injectable Hydrogel Depot System for the Controlled Release of Retinal-Targeted Hybrid Nanoparticles

et al. 2022

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A drawback in the development of treatments that can reach the retina is the presence of barriers in the eye that restrain compounds from reaching the target. Intravitreal injections hold promise for retinal delivery, but the natural defenses in the vitreous can rapidly degrade or eliminate therapeutic molecules. Injectable hydrogel implants, which act as a reservoir, can allow for long-term drug delivery with a single injection into the eye, but still suffer due to the fast clearance of the released drugs when traversing the vitreous and random diffusion that leads to lower pharmaceutic efficacy. A combination with HA-covered nanoparticles, which can be released from the gel and more readily pass through the vitreous to increase the delivery of therapeutic agents to the retina, represents an advanced and elegant way to overcome some of the limitations in eye drug delivery. In this article, we developed hybrid PLGA-Dotap NPs that, due to their hyaluronic acid coating, can improve in vivo distribution throughout the vitreous and delivery to retinal cells. Moreover, a hydrogel implant was developed to act as a depot for the hybrid NPs to better control and slow their release. These results are a first step to improve the treatment of retinal diseases by protecting and transporting the therapeutic treatment across the vitreous and to improve treatment options by creating a depot system for long-term treatments.

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“…Drug‐loaded PLGA particles embedded in the chemically cross‐linked hyaluronan hydrogel assured the reduction of the protein drug dosing frequency in the treatment of wet age‐related macular degeneration. [ 120 ] The system assured the sustained drug release of BSA at the rate of 0.4 µg d −1 for more than 2 months under physiological conditions.…”

Section: Recent Advances In the Design Of Hydrophobized Hydrogels As ...mentioning

confidence: 99%

Hydrophobized Hydrogels: Construction Strategies, Properties, and Biomedical Applications

Gosecka

Gosecki

Jaworska‐Krych

2023

Adv Funct Materials

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Hydrogels, as 3D networks containing huge amount of water, display similarity to soft tissues, and thus they are of wide interest in tissue engineering. Hydrogels, due to biocompatibility and porous structure, are valuable therapeutic platforms for hydrophilic drugs. Over the last decade, there has been a strong emphasis on the development of hydrogel platforms with the ability to increase the solubility of hydrophobic drugs. However, the pronounced discrepancy between the hydrophilic character of hydrogels and the hydrophobic nature of numerous pharmacologically active compounds is problematic. In recent years, different strategies are applied using special polymer constructs or composite materials exploiting the advanced scientific knowledge in the area of polymer and lipid‐based nano‐ and microcarriers hydrophobization of the hydrogel turns out to be not only valuable in terms of achieving the ability to dissolve poorly soluble drugs in water, but also proves to be crucial in obtaining bioadhesion in wet conditions, but also, unexpected abnormal water swelling behavior, as well as in mechanical properties such as the dissipation mechanism and self‐healable hydrogel properties. This review is mainly focused on recent advances in the usage of hydrophobized hydrogels in biomedical applications.

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Nanoparticle-Hydrogel Composite Drug Delivery System for Potential Ocular Applications

Cited by 27 publications

References 67 publications

Biomimetic, Injectable, and Self-Healing Hydrogels with Sustained Release of Ranibizumab to Treat Retinal Neovascularization

Biomimetic, Injectable, and Self-Healing Hydrogels with Sustained Release of Ranibizumab to Treat Retinal Neovascularization

Optimization of an Injectable Hydrogel Depot System for the Controlled Release of Retinal-Targeted Hybrid Nanoparticles

Hydrophobized Hydrogels: Construction Strategies, Properties, and Biomedical Applications

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