Nanoparticle Flow: Implications for Drug Delivery

Florence, Alexander T.

doi:10.1142/9781860949074_0002

Cited by 6 publications

(1 citation statement)

References 47 publications

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“…Florence has hypothesized that hydrodynamic effects could play a substantial role in the interaction between particles and cells or tissues in vivo, in particular in the circulatory system. 33 In order to shed some light on this issue, a multichannel microfluidic setup was developed and optimized that can be used to mimic physiological flow conditions in the lab. This chip-based system allows constant and pulsed flow.…”

Section: Discussionmentioning

confidence: 99%

A multichannel acoustically driven microfluidic chip to study particle-cell interactions

et al. 2013

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Microfluidic devices have emerged as important tools for experimental physiology. They allow to study the effects of hydrodynamic flow on physiological and pathophysiological processes, e.g., in the circulatory system of the body. Such dynamic in vitro test systems are essential in order to address fundamental problems in drug delivery and targeted imaging, such as the binding of particles to cells under flow. In the present work an acoustically driven microfluidic platform is presented in which four miniature flow channels can be operated in parallel at distinct flow velocities with only slight inter-experimental variations. The device can accommodate various channel architectures and is fully compatible with cell culture as well as microscopy. Moreover, the flow channels can be readily separated from the surface acoustic wave pumps and subsequently channelassociated luminescence, absorbance, and/or fluorescence can be determined with a standard microplate reader. In order to create artificial blood vessels, different coatings were evaluated for the cultivation of endothelial cells in the microchannels. It was found that 0.01% fibronectin is the most suitable coating for growth of endothelial monolayers. Finally, the microfluidic system was used to study the binding of 1 lm polystyrene microspheres to three different types of endothelial cell monolayers (HUVEC, HUVECtert, HMEC-1) at different average shear rates. It demonstrated that average shear rates between 0.5 s À1 and 2.25 s À1 exert no significant effect on cytoadhesion of particles to all three types of endothelial monolayers. In conclusion, the multichannel microfluidic platform is a promising device to study the impact of hydrodynamic forces on cell physiology and binding of drug carriers to endothelium. V C 2013 AIP Publishing LLC.

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Section: Discussionmentioning

confidence: 99%

A multichannel acoustically driven microfluidic chip to study particle-cell interactions

et al. 2013

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Computational Microfluidics Applied to Drug Delivery in Pulmonary and Arterial Systems

Kleinstreuer

2018

Microfluidics: Fundamental, Devices and Applications

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Improving Oral Delivery

Gabor

Fillafer²,

Neutsch³

et al. 2009

Handbook of Experimental Pharmacology

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It is estimated that 90% of all medicines are oral formulations and their market share is still increasing, due to sound advantages for the patient, the pharmaceutical industry and healthcare systems. Considering biopharmaceutical issues such as physicochemical requirements of the drug and physiological conditions, however, oral delivery is one of the most challenging routes. Recognising solubility, permeability and residence time in the gastrointestinal milieu as key parameters, different characteristics of drugs and their delivery systems such as size, pH, density, diffusion, swelling, adhesion, degradation and permeability can be adjusted to improve oral delivery. Future developments will focus on further improvement in patient compliance as well as the feasibility of administering biotech drugs via the oral route.

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Nanoparticle Flow: Implications for Drug Delivery

Cited by 6 publications

References 47 publications

A multichannel acoustically driven microfluidic chip to study particle-cell interactions

A multichannel acoustically driven microfluidic chip to study particle-cell interactions

Computational Microfluidics Applied to Drug Delivery in Pulmonary and Arterial Systems

Improving Oral Delivery

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