Nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer

PLGA-Based Nanoparticles as Cancer Drug Delivery Systems

“…Curcumin-loaded PLGA NPs were prepared by the emulsion diffusion evaporation technique using different stabilizers such as cetyl trimethylammonium bromide (CTAB) or PVA or PEG-5000. The present comprehensible data definitely testifies a well-established product profile, opening up new ways for the miracle molecule curcumin on PLGA owing to higher cellular uptake and increased in vitro bioactivity and better in vivo bioavailability in comparison to native curcumin (Shaikh et al, 2009;Acharya and Sahoo, 2011). Mukerjee and Vishwanatha formulated curcumin-loaded PLGA particles, and suggested that a nanoparticle-based formulation of curcumin has high probable as adjuvant therapy in prostate tumor (Mukerjee and Vishwanatha, 2009;Dinarvand et al, 2011).…”

Poly(ethylene glycol) enclatherated pectin-mucin submicron matrices for intravaginal anti-HIV-1 drug delivery

“…8 shows that the crystallinity of AZT-loaded PEG-encl-PEC:MUC SMMs was a result of the contribution by the highly crystalline AZT. The peaks observed in the diffractogram of AZT-loaded PEG-encl-PEC:MUC SMMs were sharp as those observed for AZT but were shifted slightly to the left by less than 1º and peak intensities were lower than those of observed for AZT which was probably because of the formation of a less crystaline complex when AZT was ecapsulated in the amorphous MUC and PEC based SMMs (Mishra et al, 2008;Santos et al, 2003, Shaikh et al, 2009. …”

“…The theoretical amount of AZT was the proportional amount of AZT in the 100mg of SMMs in reference to the loading dose. AZT release from PEG-encl-PEC:MUC SMMs was performed using the dialysis membrane technique over 24 hours in a 100mL container filled with SVF (Gupta et al, 2011;Woolfson et al, 2010;Shaikh et al, 2009). The dissolution media (simulated vaginal fluid, SVF), was prepared according to Owen and Katz's as presented in Table 3 (Owen and Katz, 1999).…”

“…obtained from Sigma-Aldrich Inc., St. Louis, USA) (Gupta et al, 2011;Shaikh et al, 2009). The tubing was securely tied at both ends and then suspended in a dissolution media filled 100mL container that was placed in an orbital shaker incubator (Orbital Shaker…”

In vitro Evaluation of the Curcumin against Fluconazole-Resistant Strains of Candida spp. and Cryptococcus neoformans

“…Curcumin has demonstrated its therapeutic potential with anti-inflammatory, antioxidant, antibacterial, antiparasitic action (Maheshwari et al, 2006), being also well documented in the treatment of breathing problems (Shaikh et al, 2009), in various chronic diseases presenting inflammation (Aggarwal and Harikumar, 2009), and the antifungal activity is another major biological effect of curcumin, in particular against Candida spp. ( Khan et al, 2012;Martins, 2009).…”