Nanoparticle delivery for transdermal HRT

Valenzuela, Pilar M.; Simon, James A.

doi:10.1016/j.nano.2012.05.008

Cited by 35 publications

(17 citation statements)

References 39 publications

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“…The outermost layer of the epidermis is the stratum corneum, comprised of a multi-layered structures of keratinocytes embedded in a matrix of hydrophobic lipids organized into tight lamellar structures [17,18]. The dermis contains a network of capillaries that connect to the systemic circulation and if a drug penetrates the stratum corneum, then it can readily reach the dermis and enter the bloodstream by passive diffusion.…”

Section: Diffusion Of Active Compoundsmentioning

confidence: 99%

“…Nanocarriers can enter into the skin and remain intact or can be degraded near the skin surface releasing the active substance to penetrate into the skin layers [18,19].…”

Section: Diffusion Of Active Compoundsmentioning

confidence: 99%

“…Some reported mathematical approaches reported are based on diffusion models that consist in partial differential equations describing drug delivery in space and time according with diffusion Fick's Laws [31]. According to diffusion Fick's Laws, penetrants are transported, through the skin, via the transcellular, intercellular and transappendageal routes [18,28,39]. These different transports are depicted in Fig.…”

Section: Fick's First Law and Passive Diffusion Modelsmentioning

confidence: 99%

“…(15), (16), (17) and (18). Considering that Km is the patch-skin partition coefficient, models to describe the process by which solute transfers between two adjacent nodes, based on Fick's Law.…”

Section: Hybrid Approach: First and Second Law Of Fickmentioning

confidence: 99%

“…(17) corresponds to an equilibrium condition at the vehicle/skin interface and Eq. (18) states that elimination of drug by capillary system follows first-order kinetics at x = b. [28,46].…”

Section: Hybrid Approach: First and Second Law Of Fickmentioning

confidence: 99%

See 4 more Smart Citations

Dermic diffusion and stratum corneum: A state of the art review of mathematical models

Couto

Fernandes

Cordeiro

et al. 2014

Journal of Controlled Release

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A B S T R A C TTransdermal biotechnologies are an ever increasing field of interest, due to the medical and pharmaceutical applications that they underlie. There are several mathematical models at use that permit a more inclusive vision of pure experimental data and even allow practical extrapolation for new dermal diffusion methodologies. However, they grasp a complex variety of theories and assumptions that allocate their use for specific situations. Models based on Fick's First Law found better use in contexts where scaled particle theory Models would be extensive in time-span but the reciprocal is also true, as context of transdermal diffusion of particular active compounds changes. This article reviews extensively the various theoretical methodologies for studying dermic diffusion in the rate limiting dermic barrier, the stratum corneum, and systematizes its characteristics, their proper context of application, advantages and limitations, as well as future perspectives.

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Section: Diffusion Of Active Compoundsmentioning

confidence: 99%

“…Nanocarriers can enter into the skin and remain intact or can be degraded near the skin surface releasing the active substance to penetrate into the skin layers [18,19].…”

Section: Diffusion Of Active Compoundsmentioning

confidence: 99%

Section: Fick's First Law and Passive Diffusion Modelsmentioning

confidence: 99%

Section: Hybrid Approach: First and Second Law Of Fickmentioning

confidence: 99%

“…(17) corresponds to an equilibrium condition at the vehicle/skin interface and Eq. (18) states that elimination of drug by capillary system follows first-order kinetics at x = b. [28,46].…”

Section: Hybrid Approach: First and Second Law Of Fickmentioning

confidence: 99%

See 3 more Smart Citations

Dermic diffusion and stratum corneum: A state of the art review of mathematical models

Couto

Fernandes

Cordeiro

et al. 2014

Journal of Controlled Release

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Development of a Water‐Dispersible Supramolecular Complex of Polyphenol with Polypeptides for Attenuation of the Allergic Response using a Mechanochemical Strategy

Kawasaki

Kawamura

Kodama

et al. 2023

Macromolecular Bioscience

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The prevalence of allergic disorders has increased worldwide in recent decades. Polyphenols, including resveratrol and curcumin, are posited to have potential as therapeutic agents for allergy; however, their use has been limited by poor water solubility. Accordingly, a highly concentrated, water dispersible, supramolecular complexes of polyphenols with polypeptides (poly‐L‐lysine, poly‐γ‐glutamic acid) and gelatin using high‐speed vibration milling are developed. The complex exhibits resistance to photobleaching and thermal radiation. Treatment of a rat basophilic leukemia cell line (RBL‐2H3) with polypeptide complexes containing resveratrol is suppressed allergic responses in vitro. Moreover, aerosolized administration of polypeptide complexes demonstrates excellent bioavailability and inhibition of immediate hypersensitivity reactions in ear tissue in vivo. Furthermore, the method avoids the use of organic solvent and therefore reduces undesirable biological responses.

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Chitin and Chitosan in Drug Delivery

Parhi

2019

Sustainable Agriculture Reviews 36

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Nanoparticle delivery for transdermal HRT

Cited by 35 publications

References 39 publications

Dermic diffusion and stratum corneum: A state of the art review of mathematical models

Dermic diffusion and stratum corneum: A state of the art review of mathematical models

Development of a Water‐Dispersible Supramolecular Complex of Polyphenol with Polypeptides for Attenuation of the Allergic Response using a Mechanochemical Strategy

Chitin and Chitosan in Drug Delivery

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