Nanoparticle Contrast Agents for Molecular Magnetic Resonance Imaging

Jun, Young‐wook; Lee, Jae Hyun; Cheon, Jinwoo

doi:10.1002/9783527610389.ch17

Cited by 8 publications

(11 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nanoparticles also have the potential to revolutionise conventional imaging techniques [ 2 ]. Conventional imaging modalities lack the combination of high sensitivity and high spatial resolution required for molecular imaging.…”

Section: Introductionmentioning

confidence: 99%

“…Conventional imaging modalities lack the combination of high sensitivity and high spatial resolution required for molecular imaging. MRI has high resolution, but lacks sensitivity to molecular signals, while high sensitivity nuclear medicine modalities such as single photon emission computed tomography (SPECT) and positron emission tomography (PET) provide superb sensitivity, at the cost of reduced spatial resolution [ 2 - 4 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Development and use of iron oxide nanoparticles (Part 1): Synthesis of iron oxide nanoparticles for MRI

Lodhia¹,

Mandarano²,

Ferris³

et al. 2010

Biomed. Imaging Interv. J.

174

119

View full text Add to dashboard Cite

Contrast agents, such as iron oxide, enhance MR images by altering the relaxation times of tissues in which the agent is present. They can also be used to label targeted molecular imaging probes. Unfortunately, no molecular imaging probe is currently available on the clinical MRI market. A promising platform for MRI contrast agent development is nanotechnology, where superparamagnetic iron oxide nanoparticles (SPIONS) are tailored for MR contrast enhancement, and/or for molecular imaging. SPIONs can be produced using a range of methods and the choice of method will be influenced by the characteristics most important for a particular application. In addition, the ability to attach molecular markers to SPIONS heralds their application in molecular imaging.There are many reviews on SPION synthesis for MRI; however, these tend to be targeted to a chemistry audience. The development of MRI contrast agents attracts experienced researchers from many fields including some researchers with little knowledge of medical imaging or MRI. This situation presents medical radiation practitioners with opportunities for involvement, collaboration or leadership in research depending on their level of commitment and their ability to learn. Medical radiation practitioners already possess a large portion of the understanding, knowledge and skills necessary for involvement in MRI development and molecular imaging. Their expertise in imaging technology, patient care and radiation safety provides them with skills that are directly applicable to research on the development and application of SPIONs and MRI.In this paper we argue that MRI SPIONs, currently limited to major research centres, will have widespread clinical use in the future. We believe that knowledge about this growing area of research provides an opportunity for medical radiation practitioners to enhance their specialised expertise to ensure best practice in a truly multi-disciplinary environment. This review outlines how and why SPIONs can be synthesised and examines their characteristics and limitations in the context of MR imaging.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development and use of iron oxide nanoparticles (Part 1): Synthesis of iron oxide nanoparticles for MRI

Lodhia¹,

Mandarano²,

Ferris³

et al. 2010

Biomed. Imaging Interv. J.

174

119

View full text Add to dashboard Cite

show abstract

“…Dextran-and modified dextran-coated iron oxide nanoparticles are very common magnetic products for biocompatible applications (e.g., Ferumoxides (Feridex or Endorem), Ferumoxtran-10 (Sinerem or Combidex), Ferucarbotran (Resovist) [14,15]). Other polysaccharides are frequently used as coating agents [16], too.…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of chondroitin‐sulfate‐A‐coated magnetite nanoparticles for biomedical applications

Tóth

Illés

Szekeres

et al. 2015

Journal of Magnetism and Magnetic Materials

View full text Add to dashboard Cite

Highlights* Novel CSA-coated core-shell magnetite nanoparticles were prepared successfully. * The aggregation range of MNPs was shifted gradually to the lower pHs by CSA loading. * CSA stabilizes electrosterically the MNPs over wide pH-range relevant to biosystems. * The salt tolerance of CSA@MNP enables them to use under physiological condition. AbstractPolysaccharides are promising candidates for manufacturing biocompatible core-shell nanoparticles with potential in vivo use. Superparamagnetic magnetite nanoparticles (MNPs) have prospective application in both diagnosis and therapy, and so developing a novel polysaccharide shell on MNP core is of great challenge. MNPs were prepared by coprecipitation, then the surface of purified MNPs was coated with chondroitin-sulfate-A (CSA) to obtain core-shell structured magnetite nanoparticles (CSA@MNP). The effect of the added amount of CSA on the surface charging and the aggregation state of MNPs at various pHs and 10 mM NaCl was measured by electrophoresis and dynamic light scattering. The amphoteric behaviour of MNPs was fundamentally modified by adsorption of CSA polyanions. A very low CSA loading induces the aggregation of MNPs, while four times more stabilizes the dispersions over the whole pH-range studied. The coagulation kinetics experiments measured at pH=6.3±0.3 showed that salt tolerance of CSA@MNPs rises up to ~150 mM NaCl.

show abstract

“…Polysaccharides are the most promising natural stabilizing agents for magnetic nanoparticles [34], e.g., dextran-coated iron oxide (Ferumoxides and Ferumoxtran-10) and carbo-dextran-coated iron oxide (Ferucarbotran) are well known products for biomedical applications [22,35]; furthermore, chitosan [36,37] and chondroitin-sulfate (CS) [38] with polyelectrolyte character are suitable for this purpose too.…”

Section: Introductionmentioning

confidence: 99%

Chondroitin-Sulfate-A-Coated Magnetite Nanoparticles: Synthesis, Characterization and Testing to Predict Their Colloidal Behavior in Biological Milieu

Tóth

Illés

Szekeres

et al. 2019

IJMS

View full text Add to dashboard Cite

Biopolymer coated magnetite nanoparticles (MNPs) are suitable to fabricate biocompatible magnetic fluid (MF). Their comprehensive characterization, however, is a necessary step to assess whether bioapplications are feasible before expensive in vitro and in vivo tests. The MNPs were prepared by co-precipitation, and after careful purification, they were coated by chondroitin-sulfate-A (CSA). CSA exhibits high affinity adsorption to MNPs (H-type isotherm). We could only make stable MF of CSA coated MNPs (CSA@MNPs) under accurate conditions. The CSA@MNP was characterized by TEM (size ~10 nm) and VSM (saturation magnetization ~57 emu/g). Inner-sphere metal–carboxylate complex formation between CSA and MNP was proved by FTIR-ATR and XPS. Electrophoresis and DLS measurements show that the CSA@MNPs at CSA-loading > 0.2 mmol/g were stable at pH > 4. The salt tolerance of the product improved up to ~0.5 M NaCl at pH~6.3. Under favorable redox conditions, no iron leaching from the magnetic core was detected by ICP measurements. Thus, the characterization predicts both chemical and colloidal stability of CSA@MNPs in biological milieu regarding its pH and salt concentration. MTT assays showed no significant impact of CSA@MNP on the proliferation of A431 cells. According to these facts, the CSA@MNPs have a great potential in biocompatible MF preparation for medical applications.

show abstract

Nanoparticle Contrast Agents for Molecular Magnetic Resonance Imaging

Cited by 8 publications

References 73 publications

Development and use of iron oxide nanoparticles (Part 1): Synthesis of iron oxide nanoparticles for MRI

Development and use of iron oxide nanoparticles (Part 1): Synthesis of iron oxide nanoparticles for MRI

Preparation and characterization of chondroitin‐sulfate‐A‐coated magnetite nanoparticles for biomedical applications

Chondroitin-Sulfate-A-Coated Magnetite Nanoparticles: Synthesis, Characterization and Testing to Predict Their Colloidal Behavior in Biological Milieu

Contact Info

Product

Resources

About