Nanoparticle–cell–nanoparticle communication by stigmergy to enhance poly(I:C) induced apoptosis in cancer cells

Abstract

<p>Nanoparticle–cell–nanoparticle communication by stigmergy was demonstrated using two capped nanodevices.</p>

Delivery of miR-200c-3p Using Tumor-Targeted Mesoporous Silica Nanoparticles for Breast Cancer Therapy

“…20 MSNs are biocompatible and biodegradable 21,22 materials with a porous structure, large specific surface area and volume, chemically and thermally stable, and can be equipped with molecular gates (also known as gatekeepers or nanovalves) able to regulate cargo delivery in response to predefined physical, chemical, or biochemical stimuli. 23−27 Thanks to their advantageous properties, MSNs have become one of the most important platforms for drugcontrolled release 28,29 and they have been used in many biomedical applications, such as drug, 30,31 gene, 32,33 and RNA 34,35 delivery; bioimaging; 36,37 chemical communication; 38,39 stigmergy; 40,41 nanomotors; 42,43 biosensing; 44,45 and theragnostic 46 and tissue engineering. 47,48 MSNs can be functionalized not only with molecular gates but also with other organic ligands and inorganic nanoparticles to provide them versatile chemical and physical properties, 49,50 which made them extraordinary versatile nanoplatforms.…”

pH-Dependent Molecular Gate Mesoporous Microparticles for Biological Control of Giardia intestinalis

“…Moreover, mesoporous silica can be equipped with "molecular gates" (also known as gate keepers or nanovalves) allowing the preparation of materials showing "zero" release, yet being able to deliver the payload on-command using external stimuli. In fact, gated materials have been used to develop different applications such as drug controlled release [20][21][22], sensing [23], or advanced communication protocols [24,25].…”

Leveraging synthetic particles for communication: from passive to active systems

“…3D). 27 First community of mesoporous particles were loaded with 9-cis-retionic acid and capped with interferon-γ. Both molecules were able to induce expression of TLR3 in SK-BR-3 breast cancer cells.…”

“…Afterwards, particle 2, S(sulf ) PIC , is internalized more effectively to induce cell apoptosis. 27 . Autoinducer 2 (AI-2) is produced and diffuses from one strain in P compartment to the other strain in R compartment, where the reporter bacteria generate fluorescence in response.…”