Nanoparticle-based targeted drug delivery

Singh, Rajesh; Lillard, James W.

doi:10.1016/j.yexmp.2008.12.004

Cited by 2,190 publications

(1,260 citation statements)

References 54 publications

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“…Sustained drug release formulations decrease dosing frequencies and simplify dosing regimens, which can improve patient compliance and subsequently reduce resistance development rates from mismanaged drug use (Osterberg and Blaschke 2005;Wang et al 2011). Targeted NPs can be especially effective at improving therapies by binding to and accumulating at sites of infections (Singh and Lillard 2009). Targeted NP delivery elevates the local concentrations of antibiotics in close proximity to bacteria, which increases drug bacteriostatic and bactericidal activities.…”

Section: Introductionmentioning

confidence: 99%

Nanoparticle targeting of Gram-positive and Gram-negative bacteria for magnetic-based separations of bacterial pathogens

Yang

Wilson

et al. 2017

Appl Nanosci

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Antimicrobial resistance is a healthcare problem of increasing significance, and there is increasing interest in developing new tools to address bacterial infections. Bacteria-targeting nanoparticles hold promise to improve drug efficacy, compliance, and safety. In addition, nanoparticles can also be used for novel applications, such as bacterial imaging or bioseperations. We here present the use of a scalable block-copolymer-directed self-assembly process, Flash NanoPrecipitation, to form zinc(II)-bis(dipicolylamine) modified nanoparticles that bind to both Grampositive and Gram-negative bacteria with specificity. Particles have tunable surface ligand densities that change particle avidity and binding efficacy. A variety of materials can be encapsulated into the core of the particles, such as optical dyes or iron oxide colloids, to produce imageable and magnetically active bacterial targeting constructs. As a proof-of-concept, these particles are used to bind and separate bacteria from solution in a magnetic column. Magnetic manipulation and separation would translate to a platform for pathogen identification or removal. These magnetic and targeted nanoparticles enable new methods to address bacterial infections.

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Section: Introductionmentioning

confidence: 99%

Nanoparticle targeting of Gram-positive and Gram-negative bacteria for magnetic-based separations of bacterial pathogens

Yang

Wilson

et al. 2017

Appl Nanosci

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“…A few other mechanisms have been proposed to increase transfection in the literature, such as passive delivery by concentration difference, 33 direct penetration of nanowires 8,9 and mechanical stimulation by microfluidics, which creates transient holes on the cell membrane that enable the diffusion of biomolecules into the cells. 34 Unlike these previous approaches, the plasmids in our study were not packaged or pre-adsorbed on a material surface before cell seeding.…”

Section: Resultsmentioning

confidence: 99%

Nanosheet transfection: effective transfer of naked DNA on silica glass

Huang

Ariga

et al. 2015

NPG Asia Mater

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Existing gene delivery technologies using nonviral vectors or physical stimulation are limited by cytotoxicity. Here, we reveal an easy and new method to fabricate silica upright nanosheets, which can be easily scaled up and used for gene delivery. We demonstrate that naked DNA can be transferred into difficult-to-transfect cells (for example, stem cells) by plating cells on silica glass with the upright nanosheets without using any vector. Gene entry is probably achieved through the integrin-FAK-Rho signaling axis, which can be activated by the cytoskeleton rearrangement on nanosheets in a limited time frame ('transfection window'). Transfecting naked GATA4-binding protein 4 plasmids into stem cells can upregulate the other two important cardiac marker genes myocyte enhancer factor 2C and T-box 5. The transfected mesenchymal stem cells express the cardiac marker proteins at 7 days after transfection, which confirms the success of the innovative gene delivery approach. The vector-free silica nanosheet-induced transfection is simple and effective but faster and safer than the conventional technologies.

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“…Studies showed that the use of ionic interaction between drug and matrix material could be very effective in increasing drug-loading. 25) The high drug-loading capacity will reduce the quantity of matrix materials for administration. In addition, it is worth mentioning that the cell culture medium-(IMDM) was specifically used in the release test in vitro owing to its some of ingredients similar to body fluid.…”

Section: Resultsmentioning

confidence: 99%

Block Ionomer Complex Micelles Based on the Self-Assembly of Poly(ethylene glycol)-block-poly(acrylic acid) and CdCl2 for Anti-tumor Drug Delivery

Wang

Liu

et al. 2011

CHEMICAL & PHARMACEUTICAL BULLETIN

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Regular ArticleSelf-assembly of amphiphilic block copolymers induces polymeric micelles which have attracted significant attention as potential delivery vehicles for genes, 1,2) imaging agents, 3) and anticancer drugs. 4,5) Normally, these polymeric micelles are characterized by unique core-shell architectures which have nanoscale size (10 to 100 nm diameter) and a fairly narrow size distribution. These unique structures endow the formed assemblies with good loading capacity and releasing efficiency. However, the incorporation of metal ions is not successful by amphiphilic block copolymer aggregates, due to the poor compatibility between the hydrophobic cores and metal ions. Recently, double-hydrophilic block copolymers (DHBCs) were developed, which contain ionic and nonionic water-soluble segments (block ionomers), as novel functional materials for pharmaceutical applications. 6) Among the DHBCs, poly(ethylene glycol)-block-poly(acrylic acid), PEG-b-PAA, is one of the most popular polymers and has been employed to prepare the polymeric micelles by the electrostatic complexation with positive-charged functional species. The PAA core of the micelles is a loading space that accommodates various positive-charged therapeutic or diagnostic molecules. The hydrophilic PEG shell is a brush-like corona that stabilizes the nanostructure in aqueous dispersion. Meanwhile, PEG is biocompatible for these physicochemical properties such as hydrophilicity, anticoagulant, solubility, non-immunogenecity, and able to resist protein adsorption, thus, it has been approved by food and drug administration (FDA) for clinical using. 7) PEG shell on the surface of micelles increases the residence time of circulation in blood, preventing interactions with serum proteins and minimizes the detection by the immune system. 8) Therefore, it is frequently used as the hydrophilic block of amphiphilic block copolymers to create some polymersomes.Chemotherapy has become an integral component of cancer treatment for most cancers. The metal anticancer drugs occupy the most promising space in the field of pharmaceutical chemotherapy. In 1991, Waalkes et al. found cadmium injection suppressed spontaneous liver tumor proliferation on the research for initiate or promote tumors on B6C3F1 mouse liver. 9) This result indicated cadmium might be used for tumor treatment. From then on, more and more attention has been paid about the effect of cadmium on antitumor. Our team has been some studies on effects of cadmium on human carcinoma cell. Likewise, our results showed that cadmium could significantly inhibit cellular proliferation, induce DNA damage, cause cell cycle arrest and apoptosis in vitro, and suppresse the growth of hepatocellular carcinoma cells xenografts in vivo. 10,11) Cadmium can induce metallothionein (MT), a non-specific protective protein which could combine with cadmium to reduce toxicity. Furthermore, due to the lower MT expression in hepatoma tissues, compared with normal liver tissue, free cadmium would preferably accumulate in hepatoma...

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Nanoparticle-based targeted drug delivery

Cited by 2,190 publications

References 54 publications

Nanoparticle targeting of Gram-positive and Gram-negative bacteria for magnetic-based separations of bacterial pathogens

Nanoparticle targeting of Gram-positive and Gram-negative bacteria for magnetic-based separations of bacterial pathogens

Nanosheet transfection: effective transfer of naked DNA on silica glass

Block Ionomer Complex Micelles Based on the Self-Assembly of Poly(ethylene glycol)-block-poly(acrylic acid) and CdCl2 for Anti-tumor Drug Delivery

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