Nanoparticle-Based Solution Deposition of Gold Films Supporting Bioresistant SAMs

Abstract

Thin films of gold on glass are prepared by solution deposition of functionalized gold nanoparticles followed by thermal treatment. The processed films adhere strongly to glass without any adhesion layers and can be micropatterned/microetched without delamination from the substrate. The formation of self-assembled monolayers (SAMs) of oligo(ethylene glycol) alkane thiols (EG SAMs) renders the films resistant to cell adhesion and allows for cell patterning.

Self-assembled Monolayers and Nanocomposite Hydrogels of Functional Nanomaterials for Tissue Engineering Applications

“…The patterned agarose stamp was pressed on the gold film surface etching the respective pattern on the substrate. The obtained gold micropatterns supported cellular patterning without the need of special surface functionalization . In another approach, micropatterning of metal nanostructures was used to study focal adhesion (FA) formation.…”

Detection of Dynamic Spatiotemporal Response to Periodic Chemical Stimulation in a Xenopus Embryonic Tissue

“…For example, chemical gradients can be controlled by manipulating the micro-environment [18], [19], delivering growth factors or modulating their activity, such as overexpressing growth factors to level the gradient or saturate receptors or genes encoding inhibitory factors or dominant negative receptors [20]. These approaches have been key tools in identifying factors that induce differentiation of a range of tissues and testing their physiological function within live embryos [21].…”

“Nanoarmoured” droplets of different shapes formed by interfacial self-assembly and crosslinking of metal nanoparticles

“…Interest in coatings and films comprising nanoparticles (NPs) of various types has been fuelled by the singular optical, 1,2 biological, 3 magnetic, 4,5 and electronic [6][7][8] properties of these nanostructured materials and as well as by their potential applications in sensors, [9][10][11] catalysis, 12 displays, 13 corrosion protection, 14,15 antireflective films, [16][17][18] bacteriostatic surfaces, 19,20 and supports for bioresistant SAMs. 21 Recently, several groups have investigated the possibility of creating NP films, in which strong interactions between the particles would render these films freestanding without the need for encapsulation in supporting matrices. 22 For example, Lin et al reported 23 the synthesis of monolayer films in which CdSe particles were connected by covalent crosslinks and were sturdy enough to fold like sheets of paper.…”

“…Free NPs were present both at the interface and in the droplet's bulk (as verified by experiments in which droplets were frozen and then ruptured and examined under the optical microscope). When, however, hexanedithiol crosslinker; typical concentration, 10 mM) was added to the organic phase and the NPs at the droplet's surface were crosslinked, 21,25 the appearance of the droplets gradually changed until after ca. 12 h they developed a golden hue (Fig.…”

“…1c) characteristic of AuNP multilayers. 21 When these droplets were examined (again, by freezing, rupturing, and microscope imaging), the aqueous solution they contained was colorless. UV-Vis spectrum of this solution showed no characteristic AuNP SPR peak indicating that all available NPs were incorporated into the metallic film whose thickness was $400 nm (or 60 NP layers).…”