Nanoparticle-Based Radiosensitization

Kempson, Ivan M.

doi:10.3390/ijms21082879

Cited by 5 publications

(5 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this Thematic Area, 56 articles have been published [ 48 , 64 , 104 , 108 , 110 , 124 , 195 , 252 , 253 , 254 , 255 , 256 , 257 , 258 , 259 , 260 , 261 , 262 , 263 , 264 , 265 , 266 , 267 , 268 , 269 , 270 , 271 , 272 , 273 , 274 , 275 , 276 , 277 , 278 , 279 , 280 , 281 , 282 , 283 , 284 , 285 , 286 , 287 , 288 , 289 , 290 , 291 , 292 , 293 , 294 , 295 , 296 , 297 , 298 , 299 , 300 ], an...…”

Section: Articles On the Various Directionsunclassified

“…A more detailed examination shows that, in this direction, as well as in the previous ones, articles in which the objects of research are organic materials clearly prevail over articles in which the objects of research are inorganic materials (36 and 20, respectively). Wherein, the overwhelming majority of articles of the “organic” profile are, in one way or another, connected with the participation of the objects with a biological origin; these include [ 64 , 124 , 254 , 255 , 256 , 257 , 258 , 259 , 260 , 261 , 262 , 263 , 274 , 277 , 278 , 282 , 284 , 289 , 291 , 292 , 293 , 294 , 295 , 296 , 298 , 299 , 300 ] and the processes in abiogenic organic materials were considered only in [ 48 , 195 , 266 , 271 , 272 , 273 , 283 , 288 , 290 ]. The thematic focus of these works, as well as the chemical compounds studied in them, is also very diverse, and even a simple listing of them here is clearly beyond the scope of this article, too.…”

Section: Articles On the Various Directionsmentioning

confidence: 99%

See 1 more Smart Citation

The Physical Chemistry and Chemical Physics (PCCP) Section of the International Journal of Molecular Sciences in Its Publications: The First 300 Thematic Articles in the First 3 Years

Михайлов¹

2021

IJMS

View full text Add to dashboard Cite

show abstract

Section: Articles On the Various Directionsunclassified

Section: Articles On the Various Directionsmentioning

confidence: 99%

The Physical Chemistry and Chemical Physics (PCCP) Section of the International Journal of Molecular Sciences in Its Publications: The First 300 Thematic Articles in the First 3 Years

Михайлов¹

2021

IJMS

View full text Add to dashboard Cite

show abstract

“…The window of radiation doses that are sufficient to achieve some tumor control effect while minimizing normal tissue complications is called the therapeutic window. Widening of this window can be achieved by using modern radiation delivery techniques or by modifying radiation effects on a cellular level using radioprotectors for normal tissue [3] or enhancing radiation damage using radiosensitizers or combination therapy [4][5][6]. The latter has been investigated extensively, primarily using metallic nanoparticles (NP) with most investigators studying gold nanoparticles (GNP) due to their high biocompatibility, high mass energy absorption coefficient and atomic number.…”

Section: Introductionmentioning

confidence: 99%

Reproducibility study of Monte Carlo simulations for nanoparticle dose enhancement and biological modeling of cell survival curves

Velten

2023

Biomed. Phys. Eng. Express

View full text Add to dashboard Cite

Nanoparticle-derived radiosensitization has been investigated by several groups using Monte Carlo simulations and biological modeling. In this work we replicated the physical simulation and biological modeling of previously published research for 50 nm gold nanoparticles irradiated with monoenergetic photons, various 250 kVp photon spectra, and spread-out Bragg peak (SOBP) protons. Monte Carlo simulations were performed using TOPAS and used condensed history Penelope low energy physics models for macroscopic dose deposition and interaction with the nanoparticle; simulation of the microscopic dose deposition from nanoparticle secondaries was performed using Geant4-DNA track structure physics. Biological modeling of survival fractions was performed using a local effect model-type approach for MDA-MB-231 breast cancer cells. Physical simulation results agreed extraordinarily well at all distances (1 nm to 10 µm from nanoparticle) for monoenergetic photons and SOBP protons in terms of dose per interaction, secondary electron dose enhancement factor, and secondary electron spectra. For 250 kVp photons the influence of the gold K-edge was investigated and found to appreciably affect the results. Calculated survival fractions similarly agreed well within one order of magnitude at macroscopic doses (i.e. without nanoparticle contribution) from 1 Gy to 10 Gy. Several 250 kVp spectra were tested to find one yielding closest agreement with previous results. This highlights the importance of a detailed description of the low energy (< 150 keV) component of photon spectra used for in-silico, as well as in-vitro, and in-vivo studies to ensure reproducibility of the experiments by the scientific community. Both, Monte Carlo simulations of physical interactions of the nanoparticle with photons and protons, as well as the biological modelling of cell survival curves agreed extraordinarily well with previously published data. Further investigation of the stochastic nature of nanoparticle radiosenstiziation is ongoing.

show abstract

“…The radiosensitizing effect of metal NPs is commonly attributed to strong irradiation-induced emission of secondary electrons. − Secondary electrons induce radiolysis of the surrounding molecular medium (consisting, to a large extent, of water) and thus increase the yield of hydroxyl radicals and other reactive oxygen species which may produce damage to tumor cells. , Exploration of the nanoscale mechanisms underlying radiosensitization by NPs is a subject of current efforts of numerous research teams worldwide. − …”

Section: Introductionmentioning

confidence: 99%

Molecular Dynamics Characterization of Radiosensitizing Coated Gold Nanoparticles in Aqueous Environment

et al. 2022

View full text Add to dashboard Cite

Functionalized metal nanoparticles (NPs) have been proposed as promising radiosensitizing agents for more efficient radiotherapy treatment using photons and ion beams. Radiosensitizing properties of NPs may depend on many different parameters (such as size, composition, and density) of the metal core, the organic coatings, and the molecular environment. A systematic exploration of each of these parameters on the atomistic level remains a formidable and costly experimental task, but it can be addressed by means of advanced computational modeling. This paper describes a detailed computational procedure for construction and atomistic-level characterization of radiosensitizing metal NPs in explicit molecular media. The procedure is general and is extensible to many different combinations of the core, coating, and environment. As an illustrative and experimentally relevant case study, we consider nanometer-sized gold NPs coated with thiol–poly(ethylene glycol)–amine molecules of different length and surface density and solvated in water at ambient conditions. The radial distribution of different atoms in the coatings as well as distribution and structural properties of water around the coated NPs are analyzed and linked to radiosensitizing properties of the NPs. It is revealed that the structure of the coating layer on the solvated NPs depends strongly on the surface density of ligands. At surface densities below ∼3 molecules/nm2 the coating represents a mixture of different conformation states, whereas elongated “brush”-like structures are formed at higher densities of ligands. The water content in denser coatings is significantly lower at distances from 1 nm up to 3 nm from the gold surface depending on the length of ligand molecules. Such dense and thick coatings may suppress the production of hydroxyl radicals by low-energy electrons emitted from the metal NPs and thus diminish their radiosensitizing properties. The presented computational framework provides precise information for a quantitative atomistic-level description of the structural properties of coated metal NPs in biologically relevant environments and so may form a basis for future developments to achieve a more realistic description of irradiation-driven chemistry effects in the vicinity of coated metal NPs.

show abstract

Nanoparticle-Based Radiosensitization

Abstract: Radiotherapy is a highly multidisciplinary field with respect to its foundations of research and development, and in its clinical utility [...]

Cited by 5 publications

References 13 publications

The Physical Chemistry and Chemical Physics (PCCP) Section of the International Journal of Molecular Sciences in Its Publications: The First 300 Thematic Articles in the First 3 Years

The Physical Chemistry and Chemical Physics (PCCP) Section of the International Journal of Molecular Sciences in Its Publications: The First 300 Thematic Articles in the First 3 Years

Reproducibility study of Monte Carlo simulations for nanoparticle dose enhancement and biological modeling of cell survival curves

Molecular Dynamics Characterization of Radiosensitizing Coated Gold Nanoparticles in Aqueous Environment

Contact Info

Product

Resources

About