Nanoparticle-based oral delivery systems for colon targeting: principles and design strategies

Lü, Lei; Chen, Gaoxian; Qiu, Yuanyuan; Li, Mingwang; Liu, Dianhua; Hu, Dehui; Gu, Xiajing; Xiao, Zeyu

doi:10.1007/s11434-016-1056-4

Cited by 57 publications

(28 citation statements)

References 59 publications

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“…Various carriers based on synthesized NPs (e.g., lipid, chitosan, polymer and silica NPs) have been designed to release the loaded drug at a specific pH value to resist digestive enzymes, and/or to require bacterial cleavage for activation. Several of these carriers are currently being investigated for clinical use [8]. We recently demonstrated that artificially synthesized NPs can deliver low doses of drugs, proteins, or siRNA to specific cell types and tissues, decreasing the systemic side effects of medications in IBD therapy [9].…”

Section: Nanoparticle Drug Delivery Systems In Ibdmentioning

confidence: 99%

Do Ginger-Derived Nanoparticles Represent an Attractive Treatment Strategy for Inflammatory Bowel Diseases?

Zhang

Collins²,

Merlin

2016

Nanomedicine (Lond.)

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Section: Nanoparticle Drug Delivery Systems In Ibdmentioning

confidence: 99%

Do Ginger-Derived Nanoparticles Represent an Attractive Treatment Strategy for Inflammatory Bowel Diseases?

Zhang

Collins²,

Merlin

2016

Nanomedicine (Lond.)

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“…There are also polyester systems containing a reductively labile azo group. These polyesters containing the azo linkages can be used in colon-specific therapy [93,94,95]. Most precisely, the aromatic poly(ether-ester) has been synthetized by classical polycondensation of 4-[(4-hydroxyphenyl)azo]benzoic acid and its derivatives.…”

Section: Polyesters With Stimuli-sensitive Linkagesmentioning

confidence: 99%

Selectively Biodegradable Polyesters: Nature-Inspired Construction Materials for Future Biomedical Applications

Urbánek

Jäger

et al. 2019

Polymers

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In the last half-century, the development of biodegradable polyesters for biomedical applications has advanced significantly. Biodegradable polyester materials containing external stimuli-sensitive linkages are favored in the development of therapeutic devices for pharmacological applications such as delivery vehicles for controlled/sustained drug release. These selectively biodegradable polyesters degrade after particular external stimulus (e.g., pH or redox potential change or the presence of certain enzymes). This review outlines the current development of biodegradable synthetic polyesters materials able to undergo hydrolytic or enzymatic degradation for various biomedical applications, including tissue engineering, temporary implants, wound healing and drug delivery.

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“…Furthermore, surface modification of the NP can facilitate its specific cell-targeting functions, enabling nano-drugs to exhibit controlled release at the site of inflamed cells and minimizing systemic toxicity. 25 The published studies have largely focused on treating IBD with mechanism-driven DDSs (including size-, charge-, pH-, pressure-, enzymatic hydrolysis-, degradation-, ligandreceptor-, and microbiome-dependent) and synthetic NPmediated DDSs (including amphiphilic prodrugs, hydrogels, mesoporous silica, and solid lipid NPs), and such applications have been extensively reviewed. 14,21,24,25 This review will touch only lightly on these topics, instead focusing on deliverable targets in IBD treatment, including the intestinal epithelium and mucus, immune cells, the lamina propria, the extracellular matrix (ECM), and the microbiota (a newly emerged target).…”

Section: Introductionmentioning

confidence: 99%

<p>Nanoparticle-Mediated Drug Delivery Systems For The Treatment Of IBD: Current Perspectives</p>

Yang¹,

Merlin²

2019

IJN

116

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Inflammatory bowel disease (IBD), which mainly consists of Crohn's disease and ulcerative colitis, is a chronic and relapsing inflammatory condition of the gastrointestinal tract. The traditional treatment strategies relied on frequent administration of high dosages of medications, including antibiotics, non-steroidal anti-inflammatory drugs, biologics, and immunomodulators, with the goal of reducing inflammation. Some of these medications were effective in alleviating the early-stage inflammatory symptoms, but their long-term efficacies were compromised by the accumulation of toxicities. Recently, nanoparticle (NP)based drugs have been widely studied for their potential to solve such problems. Various mechanisms/strategies, including size-, charge-, pH-, pressure-, degradation-, ligand-receptor-, and microbiome-dependent drug delivery systems, have been exploited in preclinical studies. A certain number of NP delivery systems have sought to target drugs to the inflamed intestine. Although several NP-based drugs have entered clinical trials for the treatment of IBD, most have failed due to premature drug release, weak targeting ability, and the high immune toxicity of some of the synthetic nanomaterials that have been used to fabricate the NPs. Therefore, there is still a need for rationally designed and stable NP drug delivery system that can specifically target drugs to the disease site, prolong the drug's residence time, and minimize systemic side effects. This review will analyze the current state of the art in NP-mediated drug delivery for IBD treatment. We will focus on topics such as deliverable targets (at the tissue or cellular level) for treating inflammation; the target-homing NP materials that can interact with such targets; and the major administration routes for treating IBD. These discussions will integrate notable trends in the research and development of IBD medications, including multi-responsive NP-mediated delivery and naturally-derived targeting NPs. Finally, current challenges and future directions will be presented in the hopes of advancing the study of NP-mediated strategies for treating IBD.

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Nanoparticle-based oral delivery systems for colon targeting: principles and design strategies

Cited by 57 publications

References 59 publications

Do Ginger-Derived Nanoparticles Represent an Attractive Treatment Strategy for Inflammatory Bowel Diseases?

Do Ginger-Derived Nanoparticles Represent an Attractive Treatment Strategy for Inflammatory Bowel Diseases?

Selectively Biodegradable Polyesters: Nature-Inspired Construction Materials for Future Biomedical Applications

<p>Nanoparticle-Mediated Drug Delivery Systems For The Treatment Of IBD: Current Perspectives</p>

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