Nanoparticle-based macromolecule drug delivery to lungs

Kumar, Nitesh; Gautam, Varsha; Kumar, Varun; Maurya, Pawan Kumar

doi:10.1016/b978-0-12-820658-4.00011-x

Cited by 5 publications

(4 citation statements)

References 97 publications

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“…4,5 Some existing technologies that allow atomization of particles within this range size include jet nebulizer, vibrating mesh nebulizer, pressurized metered dose inhaler, or dry powder inhaler. 6,7 In the past decade, surface acoustic waves (SAWs), which utilizes vibration, have been emerging as a new approach to nebulize solution into monodisperse particles for medical applications. 8−11 Another method with high potential in the field of nebulization is electrospraying (ES), which combines electricity and dispersal of fluid.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Studies show that monodisperses of 1–5 μm bronchodilator particles are optimal in terms of drug delivery efficacy inside the human body . However, other experiments also note that the range of optimal aerosol particle sizes may be much smaller than 1–5 μm, covering a range of 2.0–3.5 μm. , Some existing technologies that allow atomization of particles within this range size include jet nebulizer, vibrating mesh nebulizer, pressurized metered dose inhaler, or dry powder inhaler. , In the past decade, surface acoustic waves (SAWs), which utilizes vibration, have been emerging as a new approach to nebulize solution into monodisperse particles for medical applications. − Another method with high potential in the field of nebulization is electrospraying (ES), which combines electricity and dispersal of fluid.…”

Section: Introductionmentioning

confidence: 99%

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Charge-Reduced Particles via Self-Propelled Electrohydrodynamic Atomization for Drug Delivery Applications

Yadav

Tran

et al. 2023

ACS Appl. Mater. Interfaces

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Electrohydrodynamic atomization (EHDA) provides unparalleled control over the size and production rate of particles from solution. However, conventional methods produce highly charged particles that are not appropriate for inhalation drug delivery. We present a self-propelled EHDA system to address this challenge, a promising one-step platform for generating and delivering charge-reduced particles. Our approach uses a sharp electrode to produce ion wind, which reduces the cumulative charge in the particles and transports them to a target in front of the nozzle. We effectively controlled the morphologies of polymer products created from poly(vinylidene fluoride) (PVDF) at various concentrations. Our technique has also been proven safe for bioapplications, as evidenced by the delivery of PVDF particles onto breast cancer cells. The combination of simultaneous particle production and charge reduction, along with its direct delivery capability, makes the self-propelled EHDA a versatile technique for drug delivery applications.

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Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Charge-Reduced Particles via Self-Propelled Electrohydrodynamic Atomization for Drug Delivery Applications

Yadav

Tran

et al. 2023

ACS Appl. Mater. Interfaces

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“…Using spray drying could minimize contamination of products compared to multistep techniques that may include crystallization, solid/liquid separation, drying, and pulverization (optional). Spray dryers use some type of atomizers or spray nozzles to disperse a liquid or slurry into drop-size sprays that are rapidly dried in hot gas or air, resulting in dry powders with properties such as uniform particle size and a nearly spherical particle shape. − Several studies on making blends of magnesium citrate and other organic salts of magnesium using spray drying have been published. In 2016, Chaney and Sherman patented a spray drying method of preparing flavor-containing blends containing magnesium citrate, magnesium gluconate, and other organic salts of potassium and ferrous .…”

Section: Introductionmentioning

confidence: 99%

Magnesium Citrate Powders from Waste Bitterns via Crystallization and Spray Drying

Luong

Wang

Zurrer

et al. 2022

Ind. Eng. Chem. Res.

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The pilot-scale production of two magnesium citrate products, using a waste bittern discharged from a salt work as the raw material, was conducted in this study. Magnesium citrate nonahydrate and anhydrous magnesium citrate were prepared via crystallization and spray drying techniques, respectively, and characterized for purity, crystalline structure, particle shape, particle size distribution, and other properties. The material and energy costs were estimated based on technical data obtained from the pilot trials in conjunction with specific energy consumption of equivalent industrial-scale equipment. The costs were used to evaluate and compare the economic feasibility of both processes on a commercial scale. Although the material and energy costs at US$ 924 and US$ 33–81 per tonne, respectively, required to make magnesium citrate nonahydrate are lower than for anhydrous magnesium citrate at US$ 1256 and US$ 141 per tonne, respectively, the higher market price of anhydrous magnesium citrate at US$ 5000 per tonne compared to US$ 3000 per tonne for the hydrated form suggests production via spray drying is potentially the more profitable approach.

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“…Gold nanoparticles with appropriate modifications can be applied to diagnostic, therapeutics, drug delivery, and bioimaging (Mahato et al 2019). Nanoparticles have been applied broadly as a delivery system to macromolecules (Kumar et al 2020) to nanozymes, that is nanoparticles showing enzyme-like activity (Singh 2019). With advances in the area of nanomedicine, nanomaterials have been proved to be assured free radical scavengers or antioxidants.…”

Section: Introductionmentioning

confidence: 99%

Biomedical applications of metal oxide nanoparticles in aging and age-associated diseases

Yadav

Maurya

2021

3 Biotech

Self Cite

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Metal oxide nanoparticles are known to exhibit unique properties such as catalyzing the neutralization of superoxide anions, hydroxyl radicals, hydrogen peroxides and behave as antioxidant enzymes. Oxidative stress, damage and chronic inflammation are major causes and consequences of aging and age-associated disorders. With the increasing popularity of metal oxide nanoparticles, they have been applied in various age-related pathologies using their antioxidant property. Metal oxide nanoparticles have been used as diagnostic, therapeutic, and as theranostics. This review summarizes the applications of metal oxide nanoparticles in aging and age-associated disorders such as cardiovascular diseases, diabetes, cancer, neurodegenerative disorders. Oxidative stress plays a central role in the activation of inflammatory pathways, disturbing the mitochondrial function, decreasing the telomere length and leading the cell towards senescence or death. Oxidative damage is the common pathway in the progression of aging and related diseases. Metal oxide nanoparticles scavenge or precisely detect the generated reactive oxygen species, hence applied in both diagnostics and therapeutics.

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Nanoparticle-based macromolecule drug delivery to lungs

Cited by 5 publications

References 97 publications

Charge-Reduced Particles via Self-Propelled Electrohydrodynamic Atomization for Drug Delivery Applications

Charge-Reduced Particles via Self-Propelled Electrohydrodynamic Atomization for Drug Delivery Applications

Magnesium Citrate Powders from Waste Bitterns via Crystallization and Spray Drying

Biomedical applications of metal oxide nanoparticles in aging and age-associated diseases

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