Nanoparticle-Based Immunoengineered Approaches for Combating HIV

Bowen, Allan; Sweeney, Elizabeth E.; Fernandes, Rohan

doi:10.3389/fimmu.2020.00789

Cited by 24 publications

(14 citation statements)

References 106 publications

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“…A great variety of works are investigating new means and bioengineering techniques to deliver drugs to infected cells and/or present immunogens to immune cells in specific compartments, which could lead to enhanced efficiency of natural immune responses [ 181 , 182 , 183 , 184 , 185 , 186 ]. Pino et al demonstrated in SIV-infected RM that administration of FTY720 (fingolimod), a drug used to treat multiple sclerosis, limits viral persistence by increasing the number of cytolytic cells in the LN, a critical site for HIV/SIV replication and persistence [ 187 ].…”

Section: Evaluation Of Hiv Cure Strategies With the Help Of Nhp Modelsmentioning

confidence: 99%

Interests of the Non-Human Primate Models for HIV Cure Research

et al. 2021

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Non-human primate (NHP) models are important for vaccine development and also contribute to HIV cure research. Although none of the animal models are perfect, NHPs enable the exploration of important questions about tissue viral reservoirs and the development of intervention strategies. In this review, we describe recent advances in the use of these models for HIV cure research and highlight the progress that has been made as well as limitations using these models. The main NHP models used are (i) the macaque, in which simian immunodeficiency virus (SIVmac) infection displays similar replication profiles as to HIV in humans, and (ii) the macaque infected by a recombinant virus (SHIV) consisting of SIVmac expressing the HIV envelope gene serving for studies analyzing the impact of anti-HIV Env broadly neutralizing antibodies. Lessons for HIV cure that can be learned from studying the natural host of SIV are also presented here. An overview of the most promising and less well explored HIV cure strategies tested in NHP models will be given.

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Section: Evaluation Of Hiv Cure Strategies With the Help Of Nhp Modelsmentioning

confidence: 99%

Interests of the Non-Human Primate Models for HIV Cure Research

et al. 2021

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“…Additionally, they can be sorted out in either neutralizing antibodies (Nabs) or no neutralizing antibodies (Non-Nabs). The action of the first ones is directed at blocking infection by binding to the envelope of free viruses, while the other is toward recognition of the envelope during virus entry or on the surface of infected cells [ 136 , 137 ].…”

Section: Nanotechnology Approaches For Hiv/aids Treatmentmentioning

confidence: 99%

“…In addition, NPs significantly reduced the RNA and protein expression of HIV-1 [ 94 ]. On the other hand, current CRISPR-Cas9 delivery techniques use electroporation to facilitate DNA entry into living cells, which is difficult to control and can generate cytotoxicity [ 137 ]. Shahbazi et al showed how the use of AuNPs can mediate CRISPR-Cas9 components to target cells with higher efficiency and lower cytotoxicity [ 160 ].…”

Section: Nanotechnology Approaches For Hiv/aids Treatmentmentioning

confidence: 99%

Nanosystems Applied to HIV Infection: Prevention and Treatments

Macchione

Bedoya

Figueroa

et al. 2020

IJMS

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Sexually-transmitted infections (STIs) are a global health concern worldwide as they cause acute diseases, infertility, and significant mortality. Among the bacterial, viral, and parasitic pathogens that can be sexually transmitted, human immunodeficiency virus (HIV) has caused one of the most important pandemic diseases, which is acquired immune deficiency syndrome (AIDS). 32.7 million people have died from AIDS-related illnesses since the start of the epidemic. Moreover, in 2019, 38 million people were living with HIV worldwide. The need to deal with this viral infection becomes more obvious, because it represents not only a problem for public health, but also a substantial economic problem. In this context, it is necessary to focus efforts on developing methods for prevention, detection and treatment of HIV infections that significantly reduce the number of newly infected people and provide a better quality of life for patients. For several decades, biomedical research has been developed allowing quick solutions through the contribution of effective tools. One of them is the use of polymers as vehicles, drug carrier agents, or as macromolecular prodrugs. Moreover, nanosystems (NSs) play an especially important role in the diagnosis, prevention, and therapy against HIV infection. The purpose of this work is to review recent research into diverse NSs as potential candidates for prevention and treatment of HIV infection. Firstly, this review highlights the advantages of using nanosized structures for these medical applications. Furthermore, we provide an overview of different types of NSs used for preventing or combating HIV infection. Then, we briefly evaluate the most recent developments associated with prevention and treatment alternatives. Additionally, the implications of using different NSs are also addressed.

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“…According to a recent study, significant active therapeutics for HIV treatment defined the status of AgNPs as a known HIV antiagent in the initial phase of viral duplication and later stages of the HIV life cycle [8]. Additionally, Ag and Au's metals have demonstrated excellent biocompatibility, optical properties, high surface area to volume ratio, and excellent conductivity [9].…”

Section: Introductionmentioning

confidence: 99%

Bentonite Nanoclay Optoelectrochemical Property Improvement through Bimetallic Silver and Gold Nanoparticles

Ngcobo

Silwana

Maqhashu

et al. 2022

Journal of Nanotechnology

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This study assesses the physical and electrochemical changes of bimetallic Ag-Au nanoparticle-functionalized bentonite nanoclay. Nanoclay was studied to deduce a better sensing material/film. A chemical co-reduction method was used to synthesize bimetallic Ag-Au c nanoparticles, which were used to prepare a Ag-Au/PGV bentonite composite. Bimetallic Ag-AuNPs and their nanoclay composite were optically characterized using the scanning electron microscope, ultraviolet visible spectroscopy, X-ray diffraction, and Fourier transform infrared, whilst cyclic voltammetry (CV) and differential pulse voltammetry (DPV) were used to ascertain their electrochemical activity and properties. The results of surface morphological inspection showed an average size of 10 nm, in agreement with XRD. The bimetallic Ag-AuNPs UV/Vis characteristic wavelengths of 414 nm and 516 nm confirmed the presence of Ag and Au metals, respectively. XRD exhibited diffraction planes related to 2θ values of Ag and Au metals, whilst FTIR indicated mainly COO- functional groups from the citrate capping of bimetallic Ag-Au NPs. CV and DPV showed that bentonite nanoclay is largely insulated by silicates but exhibited a small electroactivity of Fe. The electroactivity of Ag-Au/PGV bentonite exhibited peak potentials due to Ag/Ag+ and Au/Au3+ redox couples at 0.19 V/−0.20 V and 1.37 V/0.42, respectively. The Ag-Au/PGV bentonite nanocomposite exhibited the highest surface concentration of 3.25 × 10−2 cm2, a diffusion coefficient of 2.36 × −11 cm2/s, and an electron transfer rate constant (Ks) of 1.99 × 10−4 cm2. The outcome of these results indicated that the Ag-Au/PGV bentonite nanocomposite was more electroactive than PGV. Therefore, this study accentuates Ag-Au/PGV bentonite nanocomposite as a novel and promising platform for electrochemical sensing with higher sensitivity and efficiency than other sensing materials.

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Nanoparticle-Based Immunoengineered Approaches for Combating HIV

Cited by 24 publications

References 106 publications

Interests of the Non-Human Primate Models for HIV Cure Research

Interests of the Non-Human Primate Models for HIV Cure Research

Nanosystems Applied to HIV Infection: Prevention and Treatments

Bentonite Nanoclay Optoelectrochemical Property Improvement through Bimetallic Silver and Gold Nanoparticles

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