Nanoparticle‐based imaging of inflammatory bowel disease

Wu, Yingwei; Briley, Karen; Tao, Xiaofeng

doi:10.1002/wnan.1357

Cited by 23 publications

(22 citation statements)

References 102 publications

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“…Interestingly, TSPO is located and has similar expression characteristics in the enteric nervous system (Ostuni et al, ). One study has demonstrated TSPO ligand induced mitochondrial stabilization and ROS reduction in a mouse model of inflammatory bowel disease (Issop et al, ), while others demonstrate diffuse TSPO upregulation (Bernards et al, 2015; Wu, Briley, & Tao, ). Studies of the colon and brain have separately demonstrated the pivotal role NOX‐2 derived ROS has in inflammatory disease progression (Mouzaoui et al, ; Stolk et al, ; Marín et al, ).…”

Section: Discussionmentioning

confidence: 99%

TSPO regulation in reactive gliotic diseases

McNeela

Bernick

Hines

et al. 2018

J of Neuroscience Research

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The brain is the most metabolically active organ in the body. This high metabolic demand is apparent in that 60% of the brain is comprised of mitochondria-enriched cells. A disruption of the brain's ability to meet this immense metabolic demand is central to the pathogenesis of a multitude of neurological disorders, which range from depression to Alzheimer's disease. Central to these pathologies are glial signaling and energy metabolism cascades regulating apoptosis and inflammation. Thus, diseases causing inflammation and disruption of metabolism can be correlated with glial reactivity. Acutely, reactive gliosis provides a mechanism for limiting the progression of a disease. Following chronic activation, the ability of reactive gliosis to limit disease progression decreases and, in some cases, transitions into a harmful state. The necessity for a noninvasive biomarker of disease in the brain has linked reactive gliosis with an upregulation of translocator protein (TSPO). TSPO is an 18kDa protein that is both a therapeutic target for multiple acute and chronic neuroinflammatory diseases and the leading biomarker for Alzheimer's disease. Although a central function of TSPO is not well known, the protein was named for its ability to translocate cholesterol. Increased TSPO expression is an indicator of disrupted metabolic activity and increased reactive oxygen production. The changes in TSPO expression levels both temporally and spatially relate to the pathogenesis of stroke, Alzheimer's disease, traumatic brain injury, and depression. Therefore, research into the basic function and potential therapeutics targeting TSPO will have broad implications for many diseases of the brain.

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Section: Discussionmentioning

confidence: 99%

TSPO regulation in reactive gliotic diseases

McNeela

Bernick

Hines

et al. 2018

J of Neuroscience Research

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“…A wide literature exists about the translational potential of nanotechnology in cancer or infectious diseases, but the application to IBD management has been poorly investigated. [36] In this study, we developed a targeted nanoplatform for early recognition of acute colitis. Our findings demonstrated that MAdCAM-1-targeted nanoparticles actively accumulated in inflamed bowel sites due to MAdCAM-1 overexpression in endothelium.…”

Section: Discussionmentioning

confidence: 99%

Nano-Targeting of Mucosal Addressin Cell Adhesion Molecule-1 Identifies Bowel Inflammation Foci in Murine Model

Truffi

Colombo

Peñaranda-Avila

et al. 2017

Nanomedicine (Lond.)

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“…It is very well to accept that nanoformulation has potential in modulating inflammation. Nanotherapeutics induced with the cell membranes of cells involved in the inflammatory progression more efficiently used for effective targeted transport to inflamed tissues 148 . The innovative technology is "nanotheranostics, “which crosses all the hurdles, not properly addressed in the development of nanomedicines and albeit with many limitations to overcome 149 , 150 .…”

Section: Discussionmentioning

confidence: 99%

Review of nanotheranostics for molecular mechanisms underlying psychiatric disorders and commensurate nanotherapeutics for neuropsychiatry: The mind knockout

Kumar¹,

Chhikara²,

Gulia³

et al. 2021

Nanotheranostics

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Bio-neuronal led psychiatric abnormalities transpired by the loss of neuronal structure and function (neurodegeneration), pro-inflammatory cytokines, microglial dysfunction, altered neurotransmission, toxicants, serotonin deficiency, kynurenine pathway, and excessively produced neurotoxic substances. These uncontrolled happenings in the etiology of psychiatric disorders initiate further changes in neurotransmitter metabolism, pathologic microglial, cell activation, and impaired neuroplasticity. Inflammatory cytokines, the outcome of dysfunctional mitochondria, dysregulation of the immune system, and under stress functions of the brain are leading biochemical factors for depression and anxiety. Nanoscale drug delivery platforms, inexpensive diagnostics using nanomaterials, nano-scale imaging technologies, and ligand-conjugated nanocrystals used for elucidating the molecular mechanisms and foremost cellular communications liable for such disorders are highly capable features to study for efficient diagnosis and therapy of the mental illness. These theranostic tools made up of multifunctional nanomaterials have the potential for effective and accurate diagnosis, imaging of psychiatric disorders, and are at the forefront of leading technologies in nanotheranostics openings field as they can collectively and efficiently target the stimulated territories of the cerebellum (cells and tissues) through molecular-scale interactions with higher bioavailability, and bio-accessibility. Specifically, the nanoplatforms based neurological changes are playing a significant role in the diagnosis of psychiatric disorders and portraying the routes of functional restoration of mental disorders by newer imaging tools at nano-level in all directions. Because of these nanotherapeutic platforms, the molecules of nanomedicine can penetrate the Blood-Brain Barrier with an increased half-life of drug molecules. The discoveries in nanotheranostics and nanotherapeutics inbuilt unique multi-functionalities are providing the best multiplicities of novel nanotherapeutic potentialities with no toxicity concerns at the level of nano range.

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Nanoparticle‐based imaging of inflammatory bowel disease

Cited by 23 publications

References 102 publications

TSPO regulation in reactive gliotic diseases

TSPO regulation in reactive gliotic diseases

Nano-Targeting of Mucosal Addressin Cell Adhesion Molecule-1 Identifies Bowel Inflammation Foci in Murine Model

Review of nanotheranostics for molecular mechanisms underlying psychiatric disorders and commensurate nanotherapeutics for neuropsychiatry: The mind knockout

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