Nanoparticle-Based Dressing: The Future of Wound Treatment?

Berthet, Morgane; Gauthier, Yves; Lacroix, Céline; Verrier, Bernard; Monge, Claire

doi:10.1016/j.tibtech.2017.08.007

Cited by 5 publications

(4 citation statements)

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“…This formulation showed excellent tensile strength, large water uptake, porous morphology, and good antibacterial capacity. Owing to their inherent antibacterial and antioxidant properties, AuNPs are effective for wound healing though the inflammatory and hemostasis phases . Many research groups have used AuNPs for wound healing applications such as tissue adhesives, antibiotic delivery, and laser activated wound healing. ,− …”

Section: Biomaterial-based Approaches For Wound Therapymentioning

confidence: 99%

“…Owing to their inherent antibacterial and antioxidant properties, AuNPs are effective for wound healing though the inflammatory and hemostasis phases. 283 Many research groups have used AuNPs for wound healing applications such as tissue adhesives, antibiotic delivery, and laser activated wound healing. 270,284−286 The unique basal plane structure and shape of graphene oxide (GO) have attracted many researchers to explore its potential for wound healing applications.…”

Section: Biomaterial-based Approaches For Woundmentioning

confidence: 99%

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Biomaterials-Based Regenerative Strategies for Skin Tissue Wound Healing

Kaur

Narayanan

Garg

et al. 2022

ACS Appl. Bio Mater.

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Skin tissue wound healing proceeds through four major stages, including hematoma formation, inflammation, and neo-tissue formation, and culminates with tissue remodeling. These four steps significantly overlap with each other and are aided by various factors such as cells, cytokines (both anti- and pro-inflammatory), and growth factors that aid in the neo-tissue formation. In all these stages, advanced biomaterials provide several functional advantages, such as removing wound exudates, providing cover, transporting oxygen to the wound site, and preventing infection from microbes. In addition, advanced biomaterials serve as vehicles to carry proteins/drug molecules/growth factors and/or antimicrobial agents to the target wound site. In this review, we report recent advancements in biomaterials-based regenerative strategies that augment the skin tissue wound healing process. In conjunction with other medical sciences, designing nanoengineered biomaterials is gaining significant attention for providing numerous functionalities to trigger wound repair. In this regard, we highlight the advent of nanomaterial-based constructs for wound healing, especially those that are being evaluated in clinical settings. Herein, we also emphasize the competence and versatility of the three-dimensional (3D) bioprinting technique for advanced wound management. Finally, we discuss the challenges and clinical perspective of various biomaterial-based wound dressings, along with prospective future directions. With regenerative strategies that utilize a cocktail of cell sources, antimicrobial agents, drugs, and/or growth factors, it is expected that significant patient-specific strategies will be developed in the near future, resulting in complete wound healing with no scar tissue formation.

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Section: Biomaterial-based Approaches For Wound Therapymentioning

confidence: 99%

Section: Biomaterial-based Approaches For Woundmentioning

confidence: 99%

Biomaterials-Based Regenerative Strategies for Skin Tissue Wound Healing

Kaur

Narayanan

Garg

et al. 2022

ACS Appl. Bio Mater.

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“…Wound healing is a complex dynamic process that compromises multiple stages including hemostasis, inflammation, multiplication and remodeling. [1][2][3] After skin damage, the hemostasis phase occurs immediately, aiming to quickly stop bleeding. Hemostasis is caused by blood vessel constriction and platelet accumulation and coagulation at the vascular wound and to form a protective barrier to prevent external pathogens entering the bloodstream.…”

Section: Introductionmentioning

confidence: 99%

Procedural Promotion of Wound Healing by Graphene-Barium Titanate Nanosystem with White Light Irradiation

Wang,

Wen,

et al. 2023

IJN

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Background: Wound healing is a continuous and complex process that comprises multiple phases including hemostasis, inflammation, multiplication (proliferation) and remodeling. Although a variety of nanomaterials have been developed to control infection and accelerate wound healing, most of them can only promote one phase but not multiple phases, resulting in lower efficient healing. Although various formulations such as nitric oxide releasing wound dressings were developed for dual action, the nanostructure synthesis and the encapsulation process were complex. Materials and Methods: Here, we report on the design of graphene-barium titanate nanosystem to procedural promote the wound healing process. The antibacterial effect was assessed in Gram-negative Escherichia coli bacteria (E. coli) and Gram-positive Staphylococcus aureus bacteria (S. aureus), the cell proliferation and migration experiment was investigated in mouse embryonic fibroblast (NIH-3T3) cells, and the wound healing effect was analyzed in female BALB/c mice with infected skin wound on the back. Results: Results showed that graphene-barium titanate nanosystem could generate abundant ROS to kill both E. coli and S. aureus. The growth curves, bacterial viability, colony number formation and scanning electron microscopy (SEM) images of E. coli and S. aureus all confirmed the antibacterial effect. Cell Counting Kit-8 (CCK-8) assay displayed that GBT possesses great biocompatibility. EdU assay showed that GBT plus white light irradiation significantly promoted the proliferation and migration of NIH-3T3 cells. Scratch assay found that GBT could achieve a fast scratch closure compared to the control. In vivo wound healing effect indicates that GBT can accelerate wound repair procedure. Conclusion: GBT nanocomposite is capable of programmatically accelerating wound healing through multiple stages, including production of a large amount of ROS after white light exposure to effectively kill E. coli and S. aureus to prevent wound infection and as a scaffold to accelerate fibroblast proliferation and migration to the wound to accelerate wound healing.

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“…It acts as a protective barrier against the external environment and helps to prevent dehydration (Mulholland et al, 2017), which highlights the importance to maintain its integrity. Reconstructing functional skin after a wound remains a challenge due to the complexity of healing, involving orchestrated cell-signalling events and biochemical cascades (Berthet, Gauthier, Lacroix, Verrier, & Monge, 2017).…”

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confidence: 99%

Natural actives for wound healing: A review

Ataide

Cefali

Croisfelt

et al. 2018

Phytotherapy Research

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Nature has been a source of medicinal treatments for thousands of years, with the use of plants as prototypes for drug development and for the extraction of active compounds. Skin injuries occur regularly in everyday life, and the human skin has the ability to promote repair spontaneously under healthy conditions. However, some intrinsic and external factors may interfere with skins' natural ability, leading to nonhealing lesions and chronic wounds, which directly affect health and quality of life. Thus, attention should be given to this health problem, using an appropriated management when necessary. In this scenario, phytotherapy may be an option for cutaneous wound treatment, although further high-quality studies are needed to firmly establish the clinical efficacy of plants. This article reviews traditionally used natural actives for wound healing, highlighting their characteristics and mode of action.

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Nanoparticle-Based Dressing: The Future of Wound Treatment?

Cited by 5 publications

References 0 publications

Biomaterials-Based Regenerative Strategies for Skin Tissue Wound Healing

Biomaterials-Based Regenerative Strategies for Skin Tissue Wound Healing

Procedural Promotion of Wound Healing by Graphene-Barium Titanate Nanosystem with White Light Irradiation

Natural actives for wound healing: A review

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