Nanoparticle-Based Brain Targeted Delivery Systems

Grover, Aditya; Hirani, Anjali; Sutariya, Vijaykumar

doi:10.4172/2167-7956.1000e113

Cited by 12 publications

(3 citation statements)

References 20 publications

(35 reference statements)

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“…Curcumin is an anti‐inflammatory and antioxidant molecule with a low molecular weight that can be used as a drug to decrease the level of Aβ and destructive plaques in the brain that gives rise to the treatment of AD and reduces its symptoms . Hydrophobicity , low solubility in water, fast systemic removal, low absorption in tissue, and being destroyed at alkaline pH are some of its characteristics that make some difficulties while using it in the body; for this reason, nanostructures are applied to deliver this agent to the brain . Taylor et al.…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of curcumin‐loaded polymeric nanomicelles to interference with amyloidogenesis through glycation method

Mirzaie

Ansari

Kordestani

et al. 2019

Biotech and App Biochem

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Amyloid fibrils, including β-amyloid (Aβ) fibrils, are protein aggregates that form under certain conditions, associated with neurodegeneration that interfere with neural synaptic transmission resulting in some neural disorders, such as Alzheimer's disease. The aim of this study is to inhibit amyloidogenesis by using preparatory polymeric nanomicelles as therapeutic agents and also as nanocarriers for curcumin to target Aβ fibrils through the glycation method of bovine serum albumin (BSA) in the presence of phosphate-buffered saline. Polymeric nanomicelles were prepared from phosphatidylethanolamine-distearoyl methoxypolyethylene glycol conjugates in the presence and absence of curcumin and then the morphological and structural characteristics of the nanomicelles were characterized in detail. Following the preparation of unloaded and curcumin-loaded nanomicelles with the desired size and properties, their effects on BSA glycation/fibrillation process were investigated. The samples were analyzed by thioflavin T (ThT) fluorescence and advanced glycation end (AGE) products autofluorescence measurements. The results showed that ThT fluorescence related to the formation of β-sheets and AGE autofluorescence (associated with AGE production) decreased in the presence of curcumin-loaded nanomicelles more than other samples. In conclusion, the promising effect of curcumin-loaded nanomicelles on inhibition of amyloidogenesis through glycation process due to curcumin release and thus their ability to prevent the formation and accumulation of amyloid fibrils and so to suppress the Alzheimer's disease progression has been proven and can go for further investigations.

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Section: Introductionmentioning

confidence: 99%

Preparation and characterization of curcumin‐loaded polymeric nanomicelles to interference with amyloidogenesis through glycation method

Mirzaie

Ansari

Kordestani

et al. 2019

Biotech and App Biochem

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“…One strategy for brain drug delivery is bypassing the BBB using highly invasive methods such as intracerebral and intracerebroventricular administration [8][9], or non-invasive methods such as intranasal delivery. Another strategy is blood-to-brain delivery via circulatory system as a result of transient BBB disruption induced by biological, chemical or physical stimuli such as zonula occludens toxin, mannitol, magnetic heating and ultrasound [10][11][12][13]. These brain drug delivery strategies have not been widely used because they are risky, costly, or unsuitable for less localized brain diseases [14].…”

Section: Introductionmentioning

confidence: 99%

Nano carriers for drug transport across the blood–brain barrier

Tsibouklis

Weng³

et al. 2016

Journal of Drug Targeting

206

124

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Effective therapy lies in achieving a therapeutic amount of drug to the proper site in the body and then maintaining the desired drug concentration for a sufficient time interval to be clinically effective for treatment. The blood-brain barrier (BBB) hinders most drugs from entering the central nervous system (CNS) from the blood stream, leading to the difficulty of delivering drugs to the brain via the circulatory system for the treatment, diagnosis and prevention of brain diseases. Several brain drug delivery approaches have been developed, such as intracerebral and intracerebroventricular administration, intranasal delivery and blood-to-brain delivery, as a result of transient BBB disruption induced by biological, chemical or physical stimuli such as zonula occludens toxin, mannitol, magnetic heating and ultrasound, but these approaches showed disadvantages of being dangerous, high cost and unsuitability for most brain diseases and drugs. The strategy of vector-mediated blood-to-brain delivery, which involves improving BBB permeability of the drug-carrier conjugate, can minimize side effects, such as being submicrometre objects that behave as a whole unit in terms of their transport and properties, nanomaterials, are promising carrier vehicles for direct drug transport across the intact BBB as a result of their potential to enter the brain capillary endothelial cells by means of normal endocytosis and transcytosis due to their small size, as well as their possibility of being functionalized with multiple copies of the drug molecule of interest. This review provids a concise discussion of nano carriers for drug transport across the intact BBB, various forms of nanomaterials including inorganic/solid lipid/polymeric nanoparticles, nanoemulsions, quantum dots, nanogels, liposomes, micelles, dendrimers, polymersomes and exosomes are critically evaluated, their mechanisms for drug transport across the BBB are reviewed, and the future directions of this area are fully discussed.

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“…Also, PEG chains can create a barrier layer with the finality of camouflage the phagocytic cells, thus prolonging the circulation period in the blood (Owens III, Peppas, 2006;Grover, Hirani, Sutariya, 2013;Rabanel, Hildgen, Banquy, 2014). Moreover, PEG provides a system with adequate stability in physiological media, which is useful to target tumoral and inflamed regions (Beduneau et al, 2007;Diaz-Lopez et al, 2010;Hervella et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Validation of high performance liquid chromatography method for determination of meloxicam loaded PEGylated nanocapsules

Ianiski

Laporta

Rubim

et al. 2015

Braz. J. Pharm. Sci.

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A method to ensure that an analytical method will produce reliable and interpretable information about the sample must first be validated, making sure that the results can be trusted and traced. In this study, we propose to validate an analytical high performance liquid chromatography (HPLC) method for the quantitation of meloxicam loaded PEGylated nanocapsules(M-PEGNC). We performed a validation study, evaluated parameters including specificity, linearity, quantification limit, detection limit, accuracy, precision and robustness. PEGylated nanocapsules were prepared by interfacial deposition of preformed polymer, and the particle size, polydispersity index, zeta potential, pH value and encapsulation efficiency were characterized. The proposed HPLC method provides selective, linear results in the range of 1.0-40.0 μg/mL; quantification and detection limits were 1.78 μg/mL and 0.59 μg/mL, respectively; relative standard deviation for repeatability was 1.35% and intermediate precision was 0.41% and 0.61% for analyst 1 and analyst 2, respectively; accuracy between 99.23 and 101.79%; robustness between 97.13 and 98.45% for the quantification of M-PEGNC. Mean particle diameters were 261 ± 13 nm and 249 ± 20 nm, polydispersity index was 0.15 ± 0.07 and 0.17 ± 0.06, pH values were 5.0 ± 0.2 and 5.2 ± 0.1, and zeta-potential values were -37.9 ± 3.2 mV e -31.8 ± 2.8 mV for M-PEGNC and placebo(B-PEGNC), respectively. In conclusion, the proposed analytical method is suitable for the quality control of M-PEGNC. Moreover, suspensions showed monomodal size distributions and low polydispersity index indicating high homogeneity of formulations with narrow size distributions, and appropriate pH and zeta potential. The extraction process was efficient for release of meloxicam from nanostructured systems.Uniterms: High performance liquid chromatography/quantitative analysis. Meloxicam/determination. PEGylated nanocapsules/quality control. Nanoparticles. Poly(ethylene glycol).Para se assegurar que um método analítico produzirá informação confiável e interpretável sobre a amostra este deve ser inicialmente validado, tornando claro que os resultados podem ser confiados e rastreados. Neste estudo, propomos validar um método de cromatografia líquida de alta eficiência (CLAE) para a quantificação do meloxicam encapsulado em nanocápsulas PEGuiladas (M-PEGNC). Efetuamos a validação, avaliando parâmetros de especificidade, linearidade, limite de quantificação, limite de detecção, exatidão, precisão e robustez. As nanocápsulas PEGuiladas foram preparadas por deposição interfacial do polímero pré-formado e caracterizaram-se o tamanho da partícula, índice de polidispersão, potencial zeta, pH e eficiência de encapsulação. O método de CLAE proposto fornece resultados seletivos e lineares na faixa de 1,0-40,0 mg/mL; limites de quantificação e detecção de 1,78 mg/mL e 0,59 mg/mL, respectivamente; desvio padrão relativo para a repetibilidade de 1,35% e precisão intermediária de 0,41% e 0,61% para o analista 1 e analista 2, respectivamente; exatidã...

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Nanoparticle-Based Brain Targeted Delivery Systems

Cited by 12 publications

References 20 publications

Preparation and characterization of curcumin‐loaded polymeric nanomicelles to interference with amyloidogenesis through glycation method

Preparation and characterization of curcumin‐loaded polymeric nanomicelles to interference with amyloidogenesis through glycation method

Nano carriers for drug transport across the blood–brain barrier

Validation of high performance liquid chromatography method for determination of meloxicam loaded PEGylated nanocapsules

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