Nanoparticle as a novel tool in hyperthermic intraperitoneal and pressurized intraperitoneal aerosol chemotheprapy to treat patients with peritoneal carcinomatosis

Nowacki, Maciej; Peterson, Margarita; Kloskowski, Tomasz; McCabe, Eleanor; Guiral, Delia Cortés; Połom, Karol; Pietkun, Katarzyna; Zegarska, Barbara; Pokrywczyńska, Marta; Roviello, Franco; Medina, Edward A.; Habib, Samy L.; Zegarski, Wojciech

doi:10.18632/oncotarget.20596

Cited by 21 publications

(20 citation statements)

References 143 publications

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“…With an overview, Ag and Zn were distributed to all studied organs. The highest levels of silver and zinc showed after 60 and 30 min of injection respectively with the same manner with their levels in blood depending in their speed on some factors starting from the half life of absorption which illustrated by increasing retention time of Ag NPs in peritoneal cavity compared with ZnO NPs by the effect of high molecular weight as discussed before and the amount of ions released from each kind of nnanoparticles [26].…”

Section: Ag and Zno Nps Distributionmentioning

confidence: 52%

“…with 57.50±2.50 µg/ml , 95±0.00 µg/ml after 1 h and 30 min respectively which indicate the shorter needed time for ZnO absorption in versus with Ag NPs by the effect of the low molecular weight of zinc, and the effect of lower apparent volume of distribution (Vd) compared with silver by which ZnO NPs could quickly reach distribution equilibrium between blood and tissues [22]. Lower value of maximum concentration detected in blood referred to silver compared with zinc which may caused by molecular weight variation [24], the probable aggregations of Ag NPs as the postponement in the peritoneal cavity leading to increase the surface area [23] and reduce the amount of silver that can pass through peritoneal membrane , in addition to and amount of generated ions [21], [25] and some considerable effects like lymphatic drainage , peritoneal permeability , and particle charge [26] , [27] .…”

Section: Ag and Zno Nps Absorptionmentioning

confidence: 99%

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Kinetic profile of silver and zinc oxide nanoparticles by intraperitoneal injection in mice , a comparative study

Razooki¹,

Rabee

2019

PEN

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To investigate the kinetic profile (Absorption , distribution , and excretion) of intraperitoneal injected Ag NPs (24.52 nm) and ZnO NPs (25.16 nm) in Albino mice , a single dose of the two kinds of NPs (100 mg/kg) were used for comparison .Kinetic profile in blood clarified shorter time (T max) were spend by ZnO NPs to be absorbed compared with longer one recorded by Ag NPs as their smaller volume of distribution (Vd) to confirm their higher concentration (C max) with 95 µg/ml compared with Ag NPs which stands on 57.5 µg/ml , also Ag NPs needs longer time of elimination to their half values (t1/2 Elem.) in blood with lower clearance rate (CL) compared with ZnO NPs. This study discussed the distribution profile in different organs over time and pointed a considerable Ag and Zn concentrations specially in liver , spleen , intestine and kidney, also an important levels recorded in lung ,heart , testes and brain. Ag and ZnO NPs excretion manner noted a significant percentage of excretion via feces with 33 % and 83%for Ag NPs and ZnO NPs respectively compared with small percentage recorded with urine .

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Section: Ag and Zno Nps Distributionmentioning

confidence: 52%

Section: Ag and Zno Nps Absorptionmentioning

confidence: 99%

Kinetic profile of silver and zinc oxide nanoparticles by intraperitoneal injection in mice , a comparative study

Razooki¹,

Rabee

2019

PEN

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“…However, data from many studies investigating the effect of chemoaerosol particles indicates a variety in behavior patterns and pharmacologic properties [22,23]. The introduction of nanoaerosols with superior qualities over conventional PIPAC regarding their interaction with the peritoneal surface is the latest finding in this respect [15].…”

Section: Resultsmentioning

confidence: 99%

Creating nanocrystallized chemotherapy: the differences in pressurized aerosol chemotherapy (PAC) via intracavitary (IAG) and extracavitary aerosol generation (EAG) regarding particle generation, morphology and structure

Khosrawipour¹,

Schubert²,

Kulas³

et al. 2020

J. Cancer

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Background: Nanocrystallization is a promising field for the development of new drugs. This study aims to present the use of nanocrystallization via intraperitoneal nanoaerosol therapy (INAT) for the treatment of peritoneal metastases. Methods: A continuous aerosol generation device was used to aerosolize a highly concentrated doxorubicin solution within a dry CO 2 environment. The produced nanoaerosol was directed into an ex vivo abdominal model and collision of aerosol particles with placed samples was subject to further analysis via scanning-electron microscopy (SEM). SEM detected structural changes of particles caused by migration to different locations. Results: It was possible to visualize the contact of doxorubicin aerosol particles with the surface. Larger particles as well as particles closer to the aerosol generation chamber collided with the glass sample creating liquid drops, while smaller particles with more distance to the aerosol chamber collided as highly concentrated nanocrystals. The amount of nanocrystal particles outweighed the amount of fluid aerosol particles by far. Conclusions: Under optimal conditions, the formation of nanocrystals via aerosol creation device is possible. While a wide range of possible applications of nanocrystals is conceivable, surface coating with drug particles is especially interesting as it may serve as an alternative to conventional liquid intraperitoneal chemotherapy. Further studies are required to investigate nanocrystallization of chemotherapeutic solutions as well as its physical and pharmacological properties and side effects.

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“…As novel molecular theranostic ligands are designed for a wide range of both targets and routes of administration (e.g., intravenous injection, inhalation, intra‐nasal delivery, etc. ), the ease‐of‐use and cost‐effectiveness of conventional imaging systems will need to be improved to support these innovations.…”

Section: Introductionmentioning

confidence: 99%

Feasibility study of a point‐of‐care positron emission tomography system with interactive imaging capability

Jiang

Komarov

et al. 2019

Medical Physics

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Purpose: We investigated the feasibility of a novel positron emission tomography (PET) system that provides near real-time feedback to an operator who can interactively scan a patient to optimize image quality. The system should be compact and mobile to support point-of-care (POC) molecular imaging applications. In this study, we present the key technologies required and discuss the potential benefits of such new capability. Methods: The core of this novel PET technology includes trackable PET detectors and a fully threedimensional, fast image reconstruction engine implemented on multiple graphics processing units (GPUs) to support dynamically changing geometry by calculating the system matrix on-the-fly using a tube-of-response approach. With near real-time image reconstruction capability, a POC-PET system may comprise a maneuverable front PET detector and a second detector panel which can be stationary or moved synchronously with the front detector such that both panels face the region-of-interest (ROI) with the detector trajectory contoured around a patient's body. We built a proof-of-concept prototype using two planar detectors each consisting of a photomultiplier tube (PMT) optically coupled to an array of 48 9 48 lutetium-yttrium oxyorthosilicate (LYSO) crystals (1.0 9 1.0 9 10.0 mm 3 each). Only 38 9 38 crystals in each arrays can be clearly re-solved and used for coincidence detection. One detector was mounted to a robotic arm which can position it at arbitrary locations, and the other detector was mounted on a rotational stage. A cylindrical phantom (102 mm in diameter, 150 mm long) with nine spherical lesions (8:1 tumor-to-background activity concentration ratio) was imaged from 27 sampling angles. List-mode events were reconstructed to form images without or with time-of-flight (TOF) information. We conducted two Monte Carlo simulations using two POC-PET systems. The first one uses the same phantom and detector setup as our experiment, with the detector coincidence re-solving time (CRT) ranging from 100 to 700 ps full-width-at-half-maximum (FWHM). The second study simulates a body-size phantom (316 9 228 9 160 mm 3 ) imaged by a larger POC-PET system that has 4 9 6 modules (32 9 32 LYSO crystals/module, four in axial and six in transaxial directions) in the front panel and 3 9 8 modules (16 9 16 LYSO crystals/module, three in axial and eight in transaxial directions) in the back panel. We also evaluated an interactive scanning strategy by progressively increasing the number of data sets used for image reconstruction. The updated images were analyzed based on the number of data sets and the detector CRT. Results: The proof-of-concept prototype re-solves most of the spherical lesions despite a limited number of coincidence events and incomplete sampling. TOF information reduces artifacts in the reconstructed images. Systems with better timing resolution exhibit improved image quality and reduced artifacts. We observed a reconstruction speed of 0.96 9 10 6 events/s/iteration for 600 9 600 9 224 voxel rect...

show abstract

Nanoparticle as a novel tool in hyperthermic intraperitoneal and pressurized intraperitoneal aerosol chemotheprapy to treat patients with peritoneal carcinomatosis

Cited by 21 publications

References 143 publications

Kinetic profile of silver and zinc oxide nanoparticles by intraperitoneal injection in mice , a comparative study

Kinetic profile of silver and zinc oxide nanoparticles by intraperitoneal injection in mice , a comparative study

Creating nanocrystallized chemotherapy: the differences in pressurized aerosol chemotherapy (PAC) via intracavitary (IAG) and extracavitary aerosol generation (EAG) regarding particle generation, morphology and structure

Feasibility study of a point‐of‐care positron emission tomography system with interactive imaging capability

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