Nanomotor-based adsorbent for blood Lead(II) removal in vitro and in pig models

Abstract

Blood lead (Pb(II)) removal is very important but challenging. The main difficulty of blood Pb(II) removal currently lies in the fact that blood Pb(II) is mainly complexed with hemoglobin (Hb) inside the red blood cells (RBCs). Traditional blood Pb(II) removers are mostly passive particles that do not have the motion ability, thus the efficiency of the contact between the adsorbent and the Pb(II)-contaminated Hb is relatively low. Herein, a kind of magnetic nanomotor adsorbent with movement ability under alternating magnetic field based on Fe 3 O 4 nanoparticle modified with meso-2, 3-dimercaptosuccinic acid (DMSA) was prepared and a blood Pb(II) removal strategy was further proposed. During the removal process, the nanomotor adsorbent can enter the RBCs, then the contact probability between the nanomotor adsorbent and the Pb(II)-contaminated Hb can be increased by the active movement of nanomotor. Through the strong coordination of functional groups in DMSA, the nanomotor adsorbent can adsorb Pb(II), and finally be separated from blood by permanent magnetic field. The in vivo extracorporeal blood circulation experiment verifies the ability of the adsorbent to remove blood Pb(II) in pig models, which may provide innovative ideas for blood heavy metal removal in the future.

Magnetic, biocompatible FeCO3 nanoparticles for T2-weighted magnetic resonance imaging of in vivo lung tumors

“…After 2 h of incubation, all samples were centrifuged, and the absorption of the resulting supernatants was measured at 561 nm. From the absorption results, we estimated the hemolysis percentage using following equation: Hemolysis rate = [(OD samples – OD negative )/(OD positive – OD negative ) × 100%] [ 29 ].…”

Dual-Mode-Driven Micromotor Based on Foam-like Carbon Nitride and Fe3O4 with Improved Manipulation and Photocatalytic Performance

“…Micro/nanomotors (MNMs) have attracted great research interest in the past decade due to their promising applications in various fields, including biomedicine, microsensing, and environmental remediation. − Among these applications, environmental remediation has attracted great interest. Due to the enhanced mass transfer and microcontact of the motors with the pollutants benefited from the locomotion and the flow-induced mixing, traditional diffusion-limited wastewater treatment can be accelerated by over one order of magnitude with the help of MNMs. , Various strategies have been proposed for the removal of contaminants, such as heavy metal ions, organic dyes, , oils, microorganisms, and even microplastics . Recently, it has been reported that the collective behavior of micromotors may offer the best solution for high-efficiency environmental remediation.…”

“…Due to the enhanced mass transfer and microcontact of the motors with the pollutants benefited from the locomotion and the flow-induced mixing, traditional diffusion-limited wastewater treatment can be accelerated by over one order of magnitude with the help of MNMs. 7,8 Various strategies have been proposed for the removal of contaminants, such as heavy metal ions, 9 organic dyes, 10,11 oils, 12 microorganisms, 13 and even microplastics. 14 Recently, it has been reported that the collective behavior of micromotors may offer the best solution for high-efficiency environmental remediation.…”

Fe3O4 Nanoparticles Coated with Mesoporous Shells for Pb(II) Removal from Blood

“…Due to the stability of lead in the bones, this dynamic balance often takes a long time, and with the current biomedical technology, it is difficult to remove the lead that exists in the bones and soft tissues. Therefore, it is of great significance to study the removal of Pb­(II) from blood. , However, blood Pb­(II) is mainly located inside red blood cells (RBCs) and binds to hemoglobin (Hb) (>95%), so it is very difficult to remove trace Pb­(II) from blood.…”

“…Therefore, it is of great significance to study the removal of Pb(II) from blood. 6,7 However, blood Pb(II) is mainly located inside red blood cells (RBCs) and binds to hemoglobin (Hb) (>95%), 8 so it is very difficult to remove trace Pb(II) from blood.…”