Nanomolar resveratrol reduces early alterations of pancreatitis and pancreatic cancer in pancreatic acinar cells

Pereira, Thiago de Melo Costa; Carvalho, Glaucimeire Rocha; Luaces-Regueira, Maria; Bugallo-Casal, Ana; Iglesias-Mejuto, Ana; Nugteren, Lonneke; Schmidt, Martina E.; Viña, Dolores; Vasquez, Elisardo C.; Campos‐Toimil, Manuel

doi:10.1016/j.phyplu.2022.100301

Cited by 2 publications

(1 citation statement)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to Pereria and colleagues, resveratrol lessens pancreatic acinar cell necrosis and early intracellular trypsin activation. In addition to this, resveratrol also inhibits NF-kB signaling leading to anti-inflammatory effects after oral administration [31]. Zhang and colleagues stated that the co-encapsulated delivery of resveratrol and docetaxel nanoliposome combination exhibited higher cytotoxicity and increased the activity caspase-3, leading to cell death in prostate cancer.…”

Section: Polyphenolsmentioning

confidence: 99%

Recent updates on nano-phyto-formulations based therapeutic intervention for cancer treatment

WAHI,

BISHNOI,

RAINA

et al. 2024

View full text Add to dashboard Cite

Cancer is a leading cause of death globally, with limited treatment options and several limitations. Chemotherapeutic agents often result in toxicity which long-term conventional treatment. Phytochemicals are natural constituents that are more effective in treating various diseases with less toxicity than the chemotherapeutic agents providing alternative therapeutic approaches to minimize the resistance. These phytoconstituents act in several ways and deliver optimum effectiveness against cancer. Nevertheless, the effectiveness of phyto-formulations in the management of cancers may be constrained due to challenges related to inadequate solubility, bioavailability, and stability. Nanotechnology presents a promising avenue for transforming current cancer treatment methods through the incorporation of phytochemicals into nanosystems, which possess a range of advantageous characteristics such as biocompatibility, targeted and sustained release capabilities, and enhanced protective effects. This holds significant potential for future advancements in cancer management. Herein, this review aims to provide intensive literature on diverse nanocarriers, highlighting their applications as cargos for phytocompounds in cancer. Moreover, it offers an overview of the current advancements in the respective field, emphasizing the characteristics that contribute to favourable outcomes in both in vitro and in vivo settings. Lastly, clinical development and regulatory concerns are also discussed to check on the transformation of the concept as a promising strategy for combination therapy of phytochemicals and chemotherapeutics that could lead to cancer management in the future.

show abstract

Section: Polyphenolsmentioning

confidence: 99%