Nanomolar detection of lansoprazole: computational–assisted to monomer–templet complex study based on molecularly imprinted polymer and electrochemical determination

Khalili, Zeinab; Nezhadali, Azizollah

doi:10.1007/s11696-021-01933-z

Cited by 6 publications

(1 citation statement)

References 42 publications

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“…Several methods were carried out for separation of LAN enantiomers [ 33 ]. Different analytical separations were described for the determination of LAN either alone or in combination with other pharmaceuticals including spectrophotometry [ 12 , 34 , 35 ], spectrofluorimetry [ 36 ], electrochemical detection [ 37 ], potentiometry [ 38 ], reversed phase high performance liquid chromatography RP-HPLC [ 39 – 41 ], HPLC using mass detector [ 42 , 43 ].…”

Section: Introductionmentioning

confidence: 99%

Validated chromatographic approach for determination of two ternary mixtures in newly approved formulations for helicobacter pylori eradication: assessment of greenness profile and content uniformity

Salem,

Elsabour,

El-Masry

2024

BMC Chemistry

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A new, sensitive, and rapid isocratic reversed phase chromatographic method (RP-HPLC–UV) was developed for simultaneous separation of two newly co-formulated antiulcer mixtures; Amoxicillin, Vonoprazan and Clarithromycin [Mixture (I)], and Amoxicillin, Lansoprazole and Clarithromycin [Mixture (II)]. Analytical separation was performed using a Promosil C18 column and ultraviolet detection at 210 nm. The separation was achieved within only 8 min. For both mixtures, an aqueous solution, composed of (Acetonitrile: Methanol: 0. 2 M phosphoric acid) within ratio of (30: 30: 40) adjusted to final pH 3.0, was the mobile phase. This method was validated as per the International Conference on Harmonization guidelines. The linearity ranges of these proposed method of the (Mixture (I)) were 25.0–400.0 µg/mL Amoxicillin, 0.5–8.0 µg/mL Vonoprazan, and 12.5–200.0 µg/mL Clarithromycin. And the linearity ranges of the (Mixture (II)) were 10.0–300.0 µg/mL Amoxicillin, 0.3–9.0 µg/mL Lansoprazole and 5.0–150.0 µg/mL Clarithromycin. This method was firstly applied for effective separation of Amoxicillin, Vonoprazan and Clarithromycin [Mixture (I)]. It fulfilled good repeatability, sensitivity, and accuracy (R.S.D. < 2.0%). The mean recoveries of the analytes in their Tri-Pak formulations were acceptable. The greenness of the developed chromatographic methods was assessed using an Eco-scale method and it was applied for content uniformity testing as per the United States Pharmacopoeia (USP) and the acceptance value of Amoxicillin, in Mixture (I) was 2.88, the acceptance values for Amoxicillin, Lansoprazole in Mixture (II) were 2.592, 2.424, respectively.

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