Nanomicelles loaded with doxorubicin and curcumin for alleviating multidrug resistance in lung cancer

Gu, Yue; Li, Jing; Yang, Li; Song, Lei; Li, Dan; Peng, Liping; Wan, Ying; Hua, Shucheng

doi:10.2147/ijn.s118568

Cited by 52 publications

(49 citation statements)

References 41 publications

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“…The cellular DNA damage and repair capacity influences the effects of an anticancer drug and can be used as a biomarker of chemotherapeutic efficacy and resistance . Moreover, resistance to apoptosis, programmed cell death, by either increase of apoptosis inhibitor protein or higher tolerance to DNA damage or DNA repair, is associated with chemoresistance and a poor clinical prognosis in cancer therapy and can be used as a marker for individualised treatment .…”

Section: Introductionmentioning

confidence: 99%

Doxorubicin kinetics and effects on lung cancer cell lines using in vitro Raman micro‐spectroscopy: binding signatures, drug resistance and DNA repair

Farhane¹,

Bonnier

Howe³

et al. 2017

Journal of Biophotonics

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Raman micro‐spectroscopy is a non‐invasive analytical tool, whose potential in cellular analysis and monitoring drug mechanisms of action has already been demonstrated, and which can potentially be used in pre‐clinical and clinical applications for the prediction of chemotherapeutic efficacy. To further investigate such potential clinical application, it is important to demonstrate its capability to differentiate drug mechanisms of action and cellular resistances. Using the example of Doxorubicin (DOX), in this study, it was used to probe the cellular uptake, signatures of chemical binding and subsequent cellular responses, of the chemotherapeutic drug in two lung cancer cell lines, A549 and Calu‐1. Multivariate statistical analysis was used to elucidate the spectroscopic signatures associated with DOX uptake and subcellular interaction. Biomarkers related to DNA damage and repair, and mechanisms leading to apoptosis were also measured and correlated to Raman spectral profiles. Results confirm the potential of Raman spectroscopic profiling to elucidate both drug kinetics and pharmacodynamics and differentiate cellular drug resistance associated with different subcellular accumulation rates and subsequent cellular response to DNA damage, pointing towards a better understanding of drug resistance for personalised targeted treatment.

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Section: Introductionmentioning

confidence: 99%

Doxorubicin kinetics and effects on lung cancer cell lines using in vitro Raman micro‐spectroscopy: binding signatures, drug resistance and DNA repair

Farhane¹,

Bonnier

Howe³

et al. 2017

Journal of Biophotonics

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“…Different nanoformulations of various phytochemicals have clearly shown that nanotechnology‐based modifications may improve the bioavailability and retention time of phytochemicals, enhance cancer cell death with minimal toxicity to normal cells, and also improve pharmacokinetic clearance. Also, certain nanoformulations such as coencapsulated pegylated polymeric micelles of doxorubicin and curcumin have been shown to overcome multidrug resistance in lung cancer (Gu et al, ). Some examples of nanoconjugated/encapsulated phytochemicals with improved anticancer efficacy have been shown in Table .…”

Section: Nanotechnology In Cancer Therapy and Drug Deliverymentioning

confidence: 99%

“…Acetyltanshinone IIA (ATA), antibreast cancer agent, encapsulated with poly (ethylene glycol) methyl ether-blockpoly (lactide-co-glycolide) (mPEG PLGA) nanoparticles, the degradable polymer used for drug delivery, has been shown to enhance the bioavailability and reduce toxicity in MCF-7 breast carcinoma cells (Wang, Wei, Liu, Chang, & Luo, 2017). Similarly, the polyethyl- (Gu et al, 2016). Some examples of nanoconjugated/ encapsulated phytochemicals with improved anticancer efficacy have been shown in Table 2.…”

Section: Nanoconjugated/encapsulated Phytochemicals With Better Antmentioning

confidence: 99%

Phytochemicals based chemopreventive and chemotherapeutic strategies and modern technologies to overcome limitations for better clinical applications

Singh

Arora

Ansari

et al. 2019

Phytotherapy Research

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Naturally occurring phytochemicals or plant derivatives are now being explored extensively for their health's benefits and medicinal uses. The therapeutic effect of phytochemicals has been reported in several pathophysiological settings such as inflammatory disorders, metabolic disorders, liver dysfunction, neurodegenerative disorders, and nephropathies. However, the most warranted therapeutic effects of phytochemicals were mapped to their anticancerous and chemopreventive action. Moreover, combining phytochemicals with standard chemotherapy has shown promising results in cancer therapy with minimal side effects and better efficacy. Many phytochemicals, like curcumin, resveratrol, and epigallocatechin‐3‐gallate, have been extensively investigated for their chemopreventive as well as chemotherapeutic effects. However, poor bioavailability, low solubility, hydrophobicity, and obscure target specificity restrict their therapeutic applications in the clinic. There has been a continually increasing interest to formulate nanoformulations of phytochemicals by using various nanocarriers, such as liposomes, micelles, nanoemulsions, and nanoparticles, to improve their bioavailability and target specificity, thereby maximizing the therapeutic potential. In the present review, we have summarized chemopreventive as well as chemotherapeutic action of some common phytochemicals and their major limitations in clinical application. Also, we have given an overview of strategies that can improve the efficacy of phytochemicals for their chemotherapeutic value in clinical settings.

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“…Curcuma domestica contains active compound curcumin that is widely known as an anti-inflammatory (Bi et al, 2016;Zhao et al, 2016), anticancer (Gu et al, 2016;Sufi et al, 2016;Tong et al, 2016) and recently antimicrobial agent (Rahayu et al, 2013;Tyagi et al, 2015). Curcumin correlates with its ability to bind to the vitamin D receptor (VDR) as a potential ligand.…”

Section: Introductionmentioning

confidence: 99%

Molecular insight into the therapeutic potential of phytoconstituents targeting protein conformation and their expression

Tiwari

2019

Phytomedicine

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Nanomicelles loaded with doxorubicin and curcumin for alleviating multidrug resistance in lung cancer

Cited by 52 publications

References 41 publications

Doxorubicin kinetics and effects on lung cancer cell lines using in vitro Raman micro‐spectroscopy: binding signatures, drug resistance and DNA repair

Doxorubicin kinetics and effects on lung cancer cell lines using in vitro Raman micro‐spectroscopy: binding signatures, drug resistance and DNA repair

Phytochemicals based chemopreventive and chemotherapeutic strategies and modern technologies to overcome limitations for better clinical applications

Molecular insight into the therapeutic potential of phytoconstituents targeting protein conformation and their expression

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