Nanomicelles-in-coaxial nanofibers with exit channels as a transdermal delivery platform for smoking cessation

Yahia, Sarah; Saad, Hadeel; Nashar, Rasha M. El; El‐Sherbiny, Ibrahim M.

doi:10.1039/d2tb00818a

Cited by 5 publications

(2 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The solution was sterilized with a 0.22 μm syringe filter before use, and the final concentration was 1 mg/mL. Mouse fibroblast cells (L929, ATCC) were seeded in a 24-well plate at a density of 50 000 cells/well and incubated in an incubator humidified with 5% CO 2 for 24 h at 37 °C. − Conditioned media from the different scaffolds (0.5 mL of 1 mg/mL solution) were added to the cells in triplicate. After 24 h of incubation at 37 °C, the medium in each well was carefully removed, followed by adding 0.5 mL PBS containing 5 mg/mL of MTT (Serva Electrophores, Heidelberg, Germany).…”

Section: Methodsmentioning

confidence: 99%

Wet Electrospun Nanofibers-Fortified Gelatin/Alginate-Based Nanocomposite as a Single-Dose Biomimicking Skin Substitute

Aboomeirah

Sarhan

Khalil

et al. 2022

ACS Appl. Bio Mater.

Self Cite

View full text Add to dashboard Cite

We report the development and evaluation of a series of well-designed single-dose extracellular matrix (ECM)-mimicking nanofibers (NFs)-reinforced hydrogel (HG)-based skin substitute for wound healing. The HG matrix of the proposed skin substitute is composed of gelatin (GE) and sodium alginate (SA), and incorporates hyaluronic acid (HA) as a key component of the natural ECM, as well as the antimicrobial Punica granatum extract (PE). This HG nanocomposite was cross-linked by the biocompatible N- (3-(dimethylamino)propyl)-N′-ethylcarbodiimide hydrochloride (EDC) cross-linker, and was reinforced with fragmented trans-ferulic acid (FA)-loaded cellulose acetate/polycaprolactone (PCL/ CA) NFs. The NFs were obtained via wet electrospinning into a poly(vinyl alcohol) (PVA) coagulating solution to closely resemble the porous structure of the ECM fibers, which facilitates cell migration, attachment, and proliferation. The proposed design of the skin substitute allows adjustable mechanical characteristics and outstanding physical properties (swelling and biodegradability), as well as an excellent porous microstructure. The developed skin substitutes were characterized using Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), and electron microscopy. In addition, the biodegradability, biocompatibility, bioactivity, mechanical, and in vitro drug release characteristics were investigated. Moreover, an in vivo excisional full-thickness defect model was conducted to assess skin regeneration and healing effectiveness. The average diameters of the plain and FA-loaded NFs are 210 ± 12 nm and 452 ± 25 nm, respectively. The developed ECM-mimicking skin substitutes demonstrated good antibacterial activity, free-radical scavenging activity, cytocompatibility, porosity, water absorption ability, and good biodegradability. In vivo application of the ECM-mimicking skin substitutes revealed their excellent wound-healing activity and their suitability for single-dose treatment of deep wounds with reducing the wound diameter to 0.95 mm after 15 days of treatment. Moreover, the histological investigation of the wound area demonstrated that the applied skin substitutes have not only enhanced the wound healing progress, but also can participate in improving the quality of the regenerated skin in the treated area via facilitating collagen fibers regeneration and deposition.

show abstract

Section: Methodsmentioning

confidence: 99%

Wet Electrospun Nanofibers-Fortified Gelatin/Alginate-Based Nanocomposite as a Single-Dose Biomimicking Skin Substitute

Aboomeirah

Sarhan

Khalil

et al. 2022

ACS Appl. Bio Mater.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Nanoparticles deliver central nervous system drugs for migraine [ 58 ], and nanofibers deliver antimicrobial drugs for endodontic disease [ 8 ]. Mucosal adhesion microspheres deliver nifedipine for the treatment of hypertension [ 59 ], and coaxial nanofibers transdermally deliver varenicline tartrate for smoking cessation [ 60 ]. In the environmental field, electrospinning can prepare MOFs for wastewater treatment applications.…”

Section: High-voltage Electrospinningmentioning

confidence: 99%

Advances in the Application of Electrospun Drug-Loaded Nanofibers in the Treatment of Oral Ulcers

et al. 2022

View full text Add to dashboard Cite

Oral ulcers affect oral and systemic health and have high prevalence in the population. There are significant individual differences in the etiology and extent of the disease among patients. In the treatment of oral ulcers, nanofiber films can control the drug-release rate and enable long-term local administration. Compared to other drug-delivery methods, nanofiber films avoid the disadvantages of frequent administration and certain side effects. Electrospinning is a simple and effective method for preparing nanofiber films. Currently, electrospinning technology has made significant breakthroughs in energy-saving and large-scale production. This paper summarizes the polymers that enable oral mucosal adhesion and the active pharmaceutical ingredients used for oral ulcers. Moreover, the therapeutic effects of currently available electrospun nanofiber films on oral ulcers in animal experiments and clinical trials are investigated. In addition, solvent casting and cross-linking methods can be used in conjunction with electrospinning techniques. Based on the literature, more administration systems with different polymers and loading components can be inspired. These administration systems are expected to have synergistic effects and achieve better therapeutic effects. This not only provides new possibilities for drug-loaded nanofibers but also brings new hope for the treatment of oral ulcers.

show abstract

Nanofibers for the Management of Allergic Airway Disease

Sharma,

Arora,

Chaudhary

et al. 2024

Understanding Allergic Airway Diseases

View full text Add to dashboard Cite

Nanomicelles-in-coaxial nanofibers with exit channels as a transdermal delivery platform for smoking cessation

Abstract: Smoking has turned to a life-threatening habit; that is why many nicotine-replacement therapies (NRTs) were reported for smoking cessation including chewing gums, nicotine patches, lozenges, mouth sprays, inhalers and nasal...

Cited by 5 publications

References 46 publications

Wet Electrospun Nanofibers-Fortified Gelatin/Alginate-Based Nanocomposite as a Single-Dose Biomimicking Skin Substitute

Wet Electrospun Nanofibers-Fortified Gelatin/Alginate-Based Nanocomposite as a Single-Dose Biomimicking Skin Substitute

Advances in the Application of Electrospun Drug-Loaded Nanofibers in the Treatment of Oral Ulcers

Nanofibers for the Management of Allergic Airway Disease

Contact Info

Product

Resources

About