Nanomedizin in der HNO-Heilkunde – ein Ausblick

Dürr, Stephan; Tietze, Rainer; Lyer, Stefan

doi:10.1055/s-0031-1291339

Cited by 5 publications

(3 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As indicated by the appraisals by the US National Cancer Institute, nanomedicine will end up being explored later on avoidance, diagnostic examination, and therapy of malignancy [5]. Nanotechnology has effectively discovered utilizations in numerous clinical fortes, for instance, in otorhinolaryngology [6]. It is generally utilized in various orders, ranging from clinical images to regenerative medication.…”

Section: Introductionmentioning

confidence: 99%

An Engineered Specificity of Anti-Neoplastic Agent Loaded Magnetic Nanoparticles for the Treatment of Breast Cancer

2021

View full text Add to dashboard Cite

Nanoparticles have gained increased attention due to the prospection of drug delivery at target sites, thus limiting the systemic effects of the drugs. Their efficiency was further improved by adding special carriers such as magnetite (Fe3O4). It is one of the extensively used oxides of iron for both pharmaceutical and biomedical applications owing to its ease of preparation and biocompatibility. In this work, Gemcitabine magnetic nanoparticles were prepared using Fe3O4 and chitosan as the primary ingredients. Optimization was accomplished by Box–Behnken Design and factor interactions were evaluated. The desirability function approach was made to enhance the formulation concerning particle size, polydispersity index, and zeta potential. Based on this, optimized magnetic nanoparticles (O-MNP) were formulated with 300 mg of Fe3O4, 297.7 mg of chitosan, and a sonication time of 2.4 h, which can achieve the prerequisites of the target formulation. All other in vitro parameters were found to be following the requirement. In vitro cytotoxic studies for O-MNP were performed using cell cultures of breast cancer (MCF-7), leukemia (THP-1), prostate cancer (PC-3), and lung cancer (A549). O-MNP showed maximum inhibition growth with MCF-7 cell lines rather than other cell lines. The data observed here demonstrates the potential of magnetic nanoparticles of gemcitabine in treating breast cancers.

show abstract

Section: Introductionmentioning

confidence: 99%

An Engineered Specificity of Anti-Neoplastic Agent Loaded Magnetic Nanoparticles for the Treatment of Breast Cancer

2021

View full text Add to dashboard Cite

show abstract

“…In order to kill tumor cells directly, anticancer drugs are usually given at the maximum dose tolerated by the patient [1], which means that the dose necessary for complete tumor eradication is barely achieved. Targeted drug delivery to the tumor may overcome this dilemma [2], and nanotechnology provides new possibilities in this rapidly growing medical field, e.g., in otorhinolaryngology [3]. Magnetic drug targeting (MDT), a new and innovative approach, has been developed to concentrate anticancer drugs in the tumor and reduce leakage into healthy tissues and cells.…”

Section: Introductionmentioning

confidence: 99%

Magnetic Drug Targeting Reduces the Chemotherapeutic Burden on Circulating Leukocytes

Janko

Dürr

Muñoz

et al. 2013

IJMS

View full text Add to dashboard Cite

Magnetic drug targeting (MDT) improves the integrity of healthy tissues and cells during treatment with cytotoxic drugs. An anticancer drug is bound to superparamagnetic iron oxide nanoparticles (SPION), injected into the vascular supply of the tumor and directed into the tumor by means of an external magnetic field. In this study, we investigated the impact of SPION, mitoxantrone (MTO) and SPIONMTO on cell viability in vitro and the nonspecific uptake of MTO into circulating leukocytes in vivo. MDT was compared with conventional chemotherapy. MTO uptake and the impact on cell viability were assessed by flow cytometry in a Jurkat cell culture. In order to analyze MTO loading of circulating leukocytes in vivo, we treated tumor-bearing rabbits with MDT and conventional chemotherapy. In vitro experiments showed a dose-dependent MTO uptake and reduction in the viability and proliferation of Jurkat cells. MTO and SPIONMTO showed similar cytotoxic activity. Non-loaded SPION did not have any effect on cell viability in the concentrations tested. Compared with systemic administration in vivo, MDT employing SPIONMTO significantly decreased the chemotherapeutic load in circulating leukocytes. We demonstrated that MDT spares the immune system in comparison with conventional chemotherapy.

show abstract

“…Magnetic nanoparticles are used in a broad spectrum of medical applications [13]. Particularly, they have been utilized for drug delivery [14–19] or used for magnetic resonance imaging as contrast media [20].…”

Section: Introductionmentioning

confidence: 99%

Impact of Superparamagnetic Iron Oxide Nanoparticles on Vocal Fold Fibroblasts: Cell Behavior and Cellular Iron Kinetics

et al. 2017

View full text Add to dashboard Cite

PurposeThe voice is the most important instrument of communication. Tissue defects in the vocal fold (VF) area lead to serious reduction in quality of life, but thus far, no satisfactory VF implant exists. Therefore, we aim to establish a functional VF implant in a rabbit model by magnetic tissue engineering (MTE) using superparamagnetic iron oxide nanoparticles (SPION). Hence, iron quantification over time as well as cell behavior studies upon SPION treatment are of great importance.MethodsRabbit VF fibroblasts (VFF) were treated with different concentrations of SPIONs (20, 40, and 80 μg/cm2), and iron content was examined for up to 40 days using microwave plasma-atom emission spectroscopy. The effects of SPION treatment on VFF (adhesion, spreading, and migration), which are important for the formation of 3D structures, were tested.ResultsCellular SPION quantification revealed that there was no residual iron remaining in VFFs after 40 days. SPIONs had a dose-dependent effect on cell adhesion, with good tolerability observed up to 20 μg/cm2. Migration and spreading were not significantly influenced by SPION treatment up to 80 μg/cm2.Discussion and ConclusionTo develop 3D structures, cell behavior should not be affected by SPION uptake. After 40 days, cells were free of iron as a result of metabolism or rarefication during cell division. Cell functions including adhesion, spreading, and migration were proven to be intact in a dose-dependent manner after SPION treatment, suggesting a safe usage of MTE for voice rehabilitation. Our results thus constitute a solid basis for a successful transfer of this technique into 3D constructs, in order to provide an individual and personalized human VF implant in the future.

show abstract

Nanomedizin in der HNO-Heilkunde – ein Ausblick

Abstract: The efforts to exploit the potential of nanotechnology in otorhinolaryngology are multifaceted, innovative and seminal. The best perspective of success is attributed to nanoparticulate drug delivery systems.

Cited by 5 publications

References 28 publications

An Engineered Specificity of Anti-Neoplastic Agent Loaded Magnetic Nanoparticles for the Treatment of Breast Cancer

An Engineered Specificity of Anti-Neoplastic Agent Loaded Magnetic Nanoparticles for the Treatment of Breast Cancer

Magnetic Drug Targeting Reduces the Chemotherapeutic Burden on Circulating Leukocytes

Impact of Superparamagnetic Iron Oxide Nanoparticles on Vocal Fold Fibroblasts: Cell Behavior and Cellular Iron Kinetics

Contact Info

Product

Resources

About