Nanomedicines for the Treatment of Systemic Candidiasis

Rana, Dhwani; Salave, Sagar; Rawat, Garima; Benival, Derajram

doi:10.1007/978-3-031-39020-3_4

AAPS Advances in the Pharmaceutical Sciences Series

2023

DOI: 10.1007/978-3-031-39020-3_4

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Nanomedicines for the Treatment of Systemic Candidiasis

Dhwani Rana,

Sagar Salave,

Garima Rawat

et al.

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2024

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Cited by 3 publications

References 116 publications

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Peptide-based targeting: Novel concept for thrombosis diagnosis and treatment

Rana,

Salave,

Benival

et al. 2024

Journal of Drug Delivery Science and Technology

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Peptide-based targeting: Novel concept for thrombosis diagnosis and treatment

Rana,

Salave,

Benival

et al. 2024

Journal of Drug Delivery Science and Technology

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Achieving Endo/Lysosomal Escape Using Smart Nanosystems for Efficient Cellular Delivery

Desai,

Rana,

Salave

et al. 2024

Molecules

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The delivery of therapeutic agents faces significant hurdles posed by the endo-lysosomal pathway, a bottleneck that hampers clinical effectiveness. This comprehensive review addresses the urgent need to enhance cellular delivery mechanisms to overcome these obstacles. It focuses on the potential of smart nanomaterials, delving into their unique characteristics and mechanisms in detail. Special attention is given to their ability to strategically evade endosomal entrapment, thereby enhancing therapeutic efficacy. The manuscript thoroughly examines assays crucial for understanding endosomal escape and cellular uptake dynamics. By analyzing various assessment methods, we offer nuanced insights into these investigative approaches’ multifaceted aspects. We meticulously analyze the use of smart nanocarriers, exploring diverse mechanisms such as pore formation, proton sponge effects, membrane destabilization, photochemical disruption, and the strategic use of endosomal escape agents. Each mechanism’s effectiveness and potential application in mitigating endosomal entrapment are scrutinized. This paper provides a critical overview of the current landscape, emphasizing the need for advanced delivery systems to navigate the complexities of cellular uptake. Importantly, it underscores the transformative role of smart nanomaterials in revolutionizing cellular delivery strategies, leading to a paradigm shift towards improved therapeutic outcomes.

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Receptor-Targeted Nanomedicine for Cancer Therapy

Prajapati,

Rangra,

Patil

et al. 2024

Receptors

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Receptor-targeted drug delivery has been extensively explored for active targeting of therapeutic moiety in cancer treatment. In this review, we discuss the receptors that are overexpressed on tumor cells and have the potential to be targeted by nanocarrier systems for cancer treatment. We also highlight the different types of nanocarrier systems and targeting ligands that researchers have explored. Our discussion covers various therapeutic modalities, including small molecules, aptamers, peptides, antibodies, and cell-based targeting strategies, and focuses on clinical developments. Additionally, this article highlights the challenges that arise during the clinical translation of nanocarrier-based targeting strategies. It also provides future directions for improving research in the area of clinically translatable cancer-targeted therapy to improve treatment efficacy while minimizing toxicity.

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Nanomedicines for the Treatment of Systemic Candidiasis

Cited by 3 publications

References 116 publications

Peptide-based targeting: Novel concept for thrombosis diagnosis and treatment

Peptide-based targeting: Novel concept for thrombosis diagnosis and treatment

Achieving Endo/Lysosomal Escape Using Smart Nanosystems for Efficient Cellular Delivery

Receptor-Targeted Nanomedicine for Cancer Therapy

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