Nanomedicines for endothelial disorders

Chung, Bomy Lee; Toth, Michael J.; Kamaly, Nazila; Sei, Yoshitaka J.; Becraft, Jacob; Mulder, Willem J. M.; Fayad, Zahi A.; Farokhzad, Omid C.; Kim, Yong Tae; Langer, Robert

doi:10.1016/j.nantod.2015.11.009

Cited by 52 publications

(39 citation statements)

References 223 publications

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“…Additionally, the reports of more and more pre-clinical systems tailored for drug-delivery applications of nanocarriers emphasize the need for other nanomedical agents than just tumors 388 in the future, e.g. for cancer immunotherapy 389 or the treatment of endothelial disorders 390 and pulmonary diseases. 391…”

Section: Conclusion For Colloidal Capsules For Biological Applicationsmentioning

confidence: 99%

Colloidal capsules: nano- and microcapsules with colloidal particle shells

2017

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Utilizing colloidal particles for the assembly of the shell of nano- and microcapsules holds great promise for the tailor-made design of new functional materials. Increasing research efforts are devoted to the synthesis of such colloidal capsules, by which the integration of modular building blocks with distinct physical, chemical, or morphological characteristics in a capsule's shell can result in novel properties, not present in previous encapsulation structures. This review will provide a comprehensive overview of the synthesis strategies and the progress made so far of bringing nano- and microcapsules with shells of densely packed colloidal particles closer to application in fields such as chemical engineering, materials science, or pharmaceutical and life science. The synthesis routes are categorized into the four major themes for colloidal capsule formation, i.e. the Pickering-emulsion based formation of colloidal capsules, the colloidal particle deposition on (sacrificial) templates, the amphiphilicity driven self-assembly of nanoparticle vesicles from polymer-grafted colloids, and the closely related field of nanoparticle membrane-loading of liposomes and polymersomes. The varying fields of colloidal capsule research are then further categorized and discussed for micro- and nano-scaled structures. Finally, a special section is dedicated to colloidal capsules for biological applications, as a diverse range of reports from this field aim at pharmaceutical agent encapsulation, targeted drug-delivery, and theranostics.

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Section: Conclusion For Colloidal Capsules For Biological Applicationsmentioning

confidence: 99%

Colloidal capsules: nano- and microcapsules with colloidal particle shells

2017

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“…In comparison to traditional formulations, nanoparticle-based nanomedicines offer many distinctive characteristics such as: 1) improved bioavailability of poorly water-soluble drugs; 2) extended blood half-life through better protection before reaching the targets; 3) controlled drug release; 4) co-delivery of multiple types of therapeutic drugs and/or diagnostic agents (for instance, contrast/imaging agents) for combination therapy, real-time readout of therapeutic outcomes, or theranostics; and 5) targeted drug delivery to improve drug efficacy and reduce systemic side effects [32, 35]. These advantages have already been realized in those nanomedicines available on market or in clinic trials [34, 36, 59, 60].…”

Section: Nanomedicines and Approaches For Homing To Macrophagesmentioning

confidence: 99%

Nanomedicines for dysfunctional macrophage-associated diseases

Ghosh

Yang

2017

Journal of Controlled Release

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Macrophages play vital functions in host inflammatory reaction, tissue repair, homeostasis and immunity. Dysfunctional macrophages have significant pathophysiological impacts on diseases such as cancer, inflammatory diseases (rheumatoid arthritis and inflammatory bowel disease), metabolic diseases (atherosclerosis, diabetes and obesity) and major infections like human immunodeficiency virus. In view of this common etiology in these diseases, targeting the recruitment, activation and regulation of dysfunctional macrophages represents a promising therapeutic strategy. With the advancement of nanotechnology, development of nanomedicines to efficiently target dysfunctional macrophages can strengthen the effectiveness of therapeutics and improve clinical outcomes. This review discusses the specific roles of dysfunctional macrophages in various diseases and summarizes the latest advances in nanomedicine-based therapeutics and theranostics for treating diseases associated with dysfunctional macrophages.

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“…Among these, nanomedicine as an emerging field that utilizes nanotechnology concepts for advanced therapy and diagnostics has attracted major interest. It has been reported that the targeting of the plaques occurs via both the vasa vasorum and the main lumen at the lesioned sites [8,9]. Vasa vasorum is a network of small microvessels or capillaries entering the plaques from the opposite site.…”

Section: Introductionmentioning

confidence: 99%

The effects of particle size, shape, density and flow characteristics on particle margination to vascular walls in cardiovascular diseases

Truong

Whittaker

et al. 2017

Expert Opinion on Drug Delivery

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Introduction: Vascular-targeted drug delivery is a promising approach for the treatment of atherosclerosis, due to the vast involvement of endothelium in the initiation and growth of plaque, a characteristic of atherosclerosis. One of the major challenges in carrier design for targeting cardiovascular diseases (CVD) is that carriers must be able to navigate the circulation system and efficiently marginate to the endothelium in order to interact with the target receptors. Areas covered: This review draws on studies that have focused on the role of particle size, shape, and density (along with flow hemodynamics and hemorheology) on the localization of the particles to activated endothelial cell surfaces and vascular walls under different flow conditions, especially those relevant to atherosclerosis. Expert opinion: Generally, the size, shape, and density of a particle affect its adhesion to vascular walls synergistically, and these three factors should be considered simultaneously when designing an optimal carrier for targeting CVD. Available preliminary data should encourage more studies to be conducted to investigate the use of nano-constructs, characterized by a sub-micrometer size, a non-spherical shape, and a high material density to maximize vascular wall margination and minimize capillary entrapment, as carriers for targeting CVD. ARTICLE HISTORY

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Nanomedicines for endothelial disorders

Cited by 52 publications

References 223 publications

Colloidal capsules: nano- and microcapsules with colloidal particle shells

Colloidal capsules: nano- and microcapsules with colloidal particle shells

Nanomedicines for dysfunctional macrophage-associated diseases

The effects of particle size, shape, density and flow characteristics on particle margination to vascular walls in cardiovascular diseases

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