Nanomedicines against Chagas disease: a critical review
Maria Jose Morilla,
Kajal Ghosal,
Eder Lilia Romero
Abstract:Chagas disease (CD) is the most important endemic parasitosis in South America and represents a great socioeconomic burden for the chronically ill and their families. The only currently available treatment against CD is based on the oral administration of benznidazole, an agent, developed in 1971, of controversial effectiveness on chronically ill patients and toxic to adults. So far, conventional pharmacological approaches have failed to offer more effective and less toxic alternatives to benznidazole. Nanomed… Show more
“…Among the articles, an interesting strategy to improve the bioavailability of benzonidazole towards Chagas disease has been presented by Muraca and colleagues, who reported a stable and safe nanostructured lipid formulation with potential effects against Trypanosoma cruzi [ 2 ] . In turn, Morilla and collaborators presented a critical review on nanomedicines and Chagas disease, highlighting the potential of oral nanocrystals and parenteral nano-immunostimulants to treat this NTD [ 3 ].…”
“…Among the articles, an interesting strategy to improve the bioavailability of benzonidazole towards Chagas disease has been presented by Muraca and colleagues, who reported a stable and safe nanostructured lipid formulation with potential effects against Trypanosoma cruzi [ 2 ] . In turn, Morilla and collaborators presented a critical review on nanomedicines and Chagas disease, highlighting the potential of oral nanocrystals and parenteral nano-immunostimulants to treat this NTD [ 3 ].…”
HS. CM-1 Moroni Multidimensional characterization of novel salts of tioconazole CM-2 Muzi Study of cpps for dissolution prediction of TCB tablets CM-3 Abarca Lachén Personalized preparation quality assurance program: pacmi. CM-4 Cabezudo Chemometric tools for quality control of Cannabis oils from the community CM-5 Perosio Variables for the design of an in vitro release test of Liposomal Drug Products (LDP): an example CM-6 Campos Modeling dissolution profiles to predict drug solubility CM-7 Juan Validation of a UV-spectrophotometric method for ivermectin quantification CM-8 Lionello Structural, spectroscopic and thermal studies of crystalline forms of tipiracil hydrochloride CM-9 Garcia Cássia Development of a sensitive LC-MS/MS method for simultaneous determination of three nitrosamines in losartan and assessment of nitrosamines' formation CM-10 Garcia Cássia Losartan potassium oral-liquid formulation for hospital use: development and stability evaluation CM-11 Pereyra Relevance of Spectral Acquisition Conditions in the Analysis of Gummies using NIR Spectrophotometry CM-12 Pereyra NIR Spectroscopy Analysis of Ganoderma Lucidum Extract in Gummies CM-13 Dubluk Determination of the specificity of the HPLC method codified in British Pharmacopoeia to quantify Gliclazide in extended-release tablets CM-14 Arce Method development for the determination of digoxin using fluorescence quenching TECNOLOGIA FARMACÉUTICA Y BIOFARMACIA TFB-1 Rabasco Alvarez Design, development and characterization of amlodipine besylateloaded Liposomes for topical application TFB-2 Awde A promising acetazolamide nanocrystals formulation for glaucoma treatment. TFB-3 Bernad-Bernad Porous microparticles made by microfluidics. LCST behavior TFB-4 Nuñez Thermal properties of mature and artificial Peloids from Presidencia Roque Sáenz Peña, Chaco TFB-5 Filia Technological optimization of Chagas disease pharmacotherapy for pediatric patients TFB-6 Castillo Development of a Liposomal-Type Microparticulate System for the Encapsulation of Algae Derivatives TFB-7 Becerra Thermodynamic analysis of Ketoprofen in N-Propanol-Water solvent mixtures TFB-8 Peverengo Polymeric particles for controlled release of isoniazid and rifampicin TFB-9 Peverengo Biopolymer matrices 3D-printed for the vehiculization and controlled release of the antibiotic octeanidine TFB-10 Pereyra Vehiculization of amiodarone in vegan gummies TFB-11 Torres Ph/thermo-sensitive lipid nanovesicles as doxorubicin carriers for cancer nanomedicine TFB-12 Dávila A new Famotidine -Gallic acid coamorphous system: an experimental and theoretical study TFB-13 Magi 3D printed Benznidazole tablets by Melting Solidification Printing Process: An innovative strategy for personalized treatment of Chagas disease TFB-14 Magi Organic solvent-free Benznidazole nanosuspension as an approach to a novel pediatric formulation for Chagas disease TFB-15 Gracia Mora Magnetoelectric nanoparticles as a form of pharmaceutical release
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