Nanomedicine Scale-up Technologies: Feasibilities and Challenges

Paliwal, Rishi; Babu, R. Jayachandra; Palakurthi, Srinath

doi:10.1208/s12249-014-0177-9

Cited by 255 publications

(148 citation statements)

References 39 publications

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“…109,110 Thus, another hurdle in the development and clinical translation of nanomaterials has been adaptation of manufacturing processes and scale-up challenges, mainly due to extensive diversity of properties of new materials. 111,112 It is fundamental to identify and control the critical points during each manufacturing process. Applying concepts of quality by design, such as process analytical technologies (PAT), will ensure an on line/at line quality assessment approach.…”

Section: Risk Assessment and Control Bandingmentioning

confidence: 99%

Nanoparticles in Daily Life: Applications, Toxicity and Regulations

Gupta

Xie

2018

J Environ Pathol Toxicol Oncol

385

188

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At nanoscale, man-made materials may show unique properties that differ from bulk and dissolved counterparts. The unique properties of engineered nanomaterials not only impart critical advantages but also confer toxicity because of their unwanted interactions with different biological compartments and cellular processes. In this review, we discuss various entry routes of nanomaterials in the human body, their applications in daily life, and the mechanisms underlying their toxicity. We further explore the passage of nanomaterials into air, water, and soil ecosystems, resulting in diverse environmental impacts. Briefly, we probe the available strategies for risk assessment and risk management to assist in reducing the occupational risks of potentially hazardous engineered nanomaterials including the control banding (CB) approach. Moreover, we substantiate the need for uniform guidelines for systematic analysis of nanomaterial toxicity, in silico toxicological investigations, and obligation to ensure the safe disposal of nanowaste to reduce or eliminate untoward environmental and health impacts. At the end, we scrutinize global regulatory trends, hurdles, and efforts to develop better regulatory sciences in the field of nanomedicines.

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Section: Risk Assessment and Control Bandingmentioning

confidence: 99%

Nanoparticles in Daily Life: Applications, Toxicity and Regulations

Gupta

Xie

2018

J Environ Pathol Toxicol Oncol

385

188

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“…Apart from nanotoxicity, another aspect to be taken into consideration while developing nanoparticle-based pharmaceuticals is their synthesis and production in bulk. Different scale-up technologies are being developed for their large-scale synthesis [132]. Cost optimization along with the demands for market supply need to be fulfilled in order to render nanoparticle-based therapeutics more suitable for clinical use.…”

Section: Discussionmentioning

confidence: 99%

Nanoparticle-Mediated Delivery of Therapeutic Drugs

Ponnappan

Chugh

2015

Pharm Med

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Nanotechnology-based pharmaceutics is a fast emerging field in the diagnosis and therapy of a number of human diseases, including cancer. Nanoparticles offer a stable means to achieve targeted drug delivery to various cells and tissues. They have been investigated for drug delivery to different tumor tissues, to brain where the blood-brain barrier poses a significant problem in the delivery of effective therapeutic molecules, to ocular tissues and also for eliciting immune response via delivery of vaccines. Particularly, the small size of nanoparticles facilitates their easy access to a wide range of cells and tissues. Further, the size of nanoparticles can be controlled and their surface can be modified with desired ligands and receptors to specifically target cells of interest as well as achieve controlled drug release. Research is being carried out on numerous biological and synthetic nanoparticles. Diverse strategies are being developed to improve their stability, specificity and drug delivery efficiency. Nanoparticles have been also used in conjunction with cellpenetrating peptides for efficient drug delivery. Cellpenetrating peptides serve as efficient nanocarriers owing to their inherent ability to cross the plasma membrane barrier and deliver cargo to intracellular targets. Modification of nanoparticles with cell-penetrating peptides further increases their efficacy for increased permeation into varied cells and tissues. The current review focuses on different classes of nanoparticles and their application in the treatment of several types of diseases. Key PointsNanoparticle-based therapeutic drugs are widely used for the treatment of a number of diseases, including cancer.Ease of modulation of size and tuning of the nanoparticles with various ligands make them effective for formulation into specific drugs with increased therapeutic index and reduced toxicity.Successful pre-clinical and early phase clinical trials have promised the emergence of nanocarrier-based drugs.

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“…89 Since materials for the preparation of nanocarrier may be a polymer, lipid, or metal, selection of method depends on the nature of it. In addition, chronic exposure to nanocarriers such as polymeric and metallic nanoparticles may cause toxicity that may be due to their size, shape, and less biodegradability.…”

Section: Formulation Development and Challengesmentioning

confidence: 99%

Recent advances and development in epidermal and dermal drug deposition enhancement technology

2018

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Skin is the largest and easily accessible organ of the body. Increases in incidences of dermatological disorders, demand for drug targeting, and patient compliance have increased the popularity of topical drug delivery amongst the people. However, drug delivery across the skin is still a challenge for researchers because permeation of maximum drugs is hindered by the upper layer of the epidermis (stratum corneum). Several approaches like use of chemical permeation enhancers and physical methods such as sonophoresis, iontophoresis, electroporation, microneedles, etc., have been used to deliver the drugs topically. These methods of topical drug delivery have some limitations and drawbacks. Therefore new techniques based on nano drug delivery system such as ultradeformable liposomes, nanostructured lipid carriers, nanoemulsions, solid lipid nanoparticles, lipospheres, nanoparticles, and ethosomes have been exploited for enhancing epidermal and dermal drug deposition. Development of these nanosytems requires a good understanding of mechanism of drug permeation, physicochemical properties of drug and carriers, and technological advancements in methodology. Therefore, this article covers recent advances in epidermal and dermal drug deposition enhancement approaches, biopharmaceutical challenges with dermal drug delivery, issues in formulation development, and regulatory aspects of nanosystem. This review article also discusses the concern of topical drug delivery in immunization, gene delivery, and cosmeceuticals.

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Nanomedicine Scale-up Technologies: Feasibilities and Challenges

Cited by 255 publications

References 39 publications

Nanoparticles in Daily Life: Applications, Toxicity and Regulations

Nanoparticles in Daily Life: Applications, Toxicity and Regulations

Nanoparticle-Mediated Delivery of Therapeutic Drugs

Recent advances and development in epidermal and dermal drug deposition enhancement technology

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