Nanomedicine Revisited: Next Generation Therapies for Brain Cancer

Bhargav, Adip G.; Mondal, Sujan Kumar; Garcia, César A.; Green, Jordan J.; Quiñones‐Hinojosa, Alfredo

doi:10.1002/adtp.202000118

Cited by 19 publications

(21 citation statements)

References 295 publications

(599 reference statements)

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“…In this setting, NP have been tested as radiosensitizing agents as well as carriers of other radiosensitizing agents, with studies demonstrating promising results after photon and particle radiation [ 44 , 46 , 47 ]. This strategy using nanomedicine aims to load NP with drugs that sensitize cancer cells to radiation, and thereby enhance the killing of residual disease and prevent treatment resistance [ 48 ]. NP as radiosensitizers has been extensively explored over the past decades; but recently high atomic number NP, such as gadolinium (Z = 79), hafnium (Z = 72), platinum (Z = 78), gold (Z = 79) or bismuth (Z = 82) have been investigated [ 49 ].…”

Section: Nanoparticlesmentioning

confidence: 99%

Novel Strategies for Nanoparticle-Based Radiosensitization in Glioblastoma

Ruiz‐Garcia

Ramírez-Loera

Malouff

et al. 2021

IJMS

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Radiotherapy (RT) is one of the cornerstones in the current treatment paradigm for glioblastoma (GBM). However, little has changed in the management of GBM since the establishment of the current protocol in 2005, and the prognosis remains grim. Radioresistance is one of the hallmarks for treatment failure, and different therapeutic strategies are aimed at overcoming it. Among these strategies, nanomedicine has advantages over conventional tumor therapeutics, including improvements in drug delivery and enhanced antitumor properties. Radiosensitizing strategies using nanoparticles (NP) are actively under study and hold promise to improve the treatment response. We aim to describe the basis of nanomedicine for GBM treatment, current evidence in radiosensitization efforts using nanoparticles, and novel strategies, such as preoperative radiation, that could be synergized with nanoradiosensitizers.

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Section: Nanoparticlesmentioning

confidence: 99%

Novel Strategies for Nanoparticle-Based Radiosensitization in Glioblastoma

Ruiz‐Garcia

Ramírez-Loera

Malouff

et al. 2021

IJMS

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“…Many advances have been made over the last 15 years in the field of nanotechnology, and increased translation into cancer treatment is justifiably anticipated [ 196 ]. An excellent review of the use of nanoparticles in brain cancer has recently been published [ 197 ]. In this section we will highlight preclinical studies that have employed nanoparticles conjugated to stem cells to improve treatment of GBM.…”

Section: Therapeutic Strategies and Their Mechanisms Of Actionmentioning

confidence: 99%

Stem cells for the treatment of glioblastoma: a 20-year perspective

et al. 2021

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Glioblastoma, the deadliest form of primary brain tumor, remains a disease without cure. Treatment resistance is in large part attributed to limitations in the delivery and distribution of therapeutic agents. Over the last 20 years, numerous preclinical studies have demonstrated the feasibility and efficacy of stem cells as antiglioma agents, leading to the development of trials to test these therapies in the clinic. In this review we present and analyze these studies, discuss mechanisms underlying their beneficial effect and highlight experimental progress, limitations and the emergence of promising new therapeutic avenues. We hope to increase awareness of the advantages brought by stem cells for the treatment of glioblastoma and inspire further studies that will lead to accelerated implementation of effective therapies.

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“…Many advances have been made over the last 15 years in the field of nanotechnology and increased translation into cancer treatment is justifiably anticipated 179 . An excellent review of the use of NPs in brain cancer has recently been published 180 . In this section we will highlight preclinical studies that have employed NPs conjugated to stem cells to improve treatment of glioblastoma.…”

Section: Stem Cell Trafficking Of Therapeutic Nanoparticlesmentioning

confidence: 99%

Harnessing Human Stem Cells for the Treatment of Glioblastoma – Twenty Year Perspective – Review of Preclinical and Clinical Studies: 2000–2020

Calinescu¹,

Kauss²,

Sultan³

et al. 2020

Preprint

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The potential of Neural Stem Cells (NSCs) to provide therapeutic benefit for a variety of neurologicaldisorders, including brain malignancies, has been long recognized and has inspired many scientists to design,test and successfully demonstrate that NSCs are efficient and effective therapeutic agents. Glioblastoma, thedeadliest form of primary brain tumor, despite extensive and sustained efforts to find better therapies, remainsa disease without cure, with a median survival after diagnosis of less than two years. Treatment resistance inglioblastoma is in large part attributed to limitations in the delivery and distribution of therapeutic agentsadministered either systemically or directly into the tumor due to the highly invasive nature of this cancer andits abnormal intratumoral vasculature. Stem Cells (SCs) have an innate tumor-tropic migratory behavior, canbe modified to deliver a variety of therapeutic agents and efficiently distribute their cargo into brain tumors,pursuing invading streams of tumor cells, deep into the brain parenchyma. Over the last twenty years,numerous preclinical trials have demonstrated the feasibility and efficacy of SCs as antiglioma agents, leadingto the development of trials to test these therapies in the clinic. In this review we present and analyze thesestudies and discuss mechanisms underlying their beneficial effect, highlighting experimental progress,limitations and the emergence of promising new therapeutic avenues. We hope to increase awareness of theadvantages of using SCs for the treatment of glioblastoma and inspire further studies that will lead toaccelerated implementation of effective therapies.

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Nanomedicine Revisited: Next Generation Therapies for Brain Cancer

Cited by 19 publications

References 295 publications

Novel Strategies for Nanoparticle-Based Radiosensitization in Glioblastoma

Novel Strategies for Nanoparticle-Based Radiosensitization in Glioblastoma

Stem cells for the treatment of glioblastoma: a 20-year perspective

Harnessing Human Stem Cells for the Treatment of Glioblastoma – Twenty Year Perspective – Review of Preclinical and Clinical Studies: 2000–2020

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