Nanomedicine Opportunities for Cardiovascular Disease with Perfluorocarbon Nanoparticles

Lanza, Gregory M.; Winter, Patrick M.; Caruthers, Shelton D.; Hughes, Michael S.; Cyrus, Tillmann; Marsh, Jon N.; Neubauer, Anne M.; Partlow, Kathryn C.; Wickline, Samuel A.

doi:10.2217/17435889.1.3.321

Cited by 65 publications

(50 citation statements)

References 49 publications

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“…43 The Wickline group systematically developed several integrin targeting imaging compounds using both different ligands and imaging compounds. Lanza et al 44 developed a nanoparticle with a perfluorocarbon core covered with a lipid monolayer, including paramagnetic lipids (Gd-DTPA-bis-oleate) in the monolayer. The nanoparticles targeted to α v β 3 -integrin detected angiogenesis in a rabbit model of atherosclerosis.…”

Section: 36mentioning

confidence: 99%

Molecular Magnetic Resonance Imaging for the Detection of Vulnerable Plaques

Adel

Daemen²,

Poelmann³

et al. 2021

ATVB

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Abstract-Recent advances in molecular resonance imaging of atherosclerosis enable to visualize atherosclerotic plaques in vivo using molecular targeted contrast agents. This offers opportunities to study atherosclerosis development and plaque vulnerability noninvasively. In this review, we discuss MRI contrast agents targeted toward atherosclerotic plaques and illustrate how these new imaging platforms could assist in our understanding of atherogenesis and atheroprogression. In particular, we highlight the challenges and limitations of the different contrast agents and hurdles for clinical application. We describe the most promising existing compounds to detect atherosclerosis and plaque vulnerability. Of particular interest are the fibrin-targeted compounds that detect thrombi and, furthermore, the contrast agents targeted to integrins that allow to visualize plaque neovascularization. Moreover, vascular cell adhesion molecule 1-targeted iron oxides seem promising for early detection of atherosclerosis. These targeted MRI contrast agents, however promising and well characterized in (pre)clinical models, lack specificity for plaque vulnerability. or cardiovascular diseases but are also upregulated in other diseases as compared with disease-free conditions. Moreover, these molecular targets are often present at relatively low levels. To overcome sensitivity issues, high-payload contrast agent vehicles have been developed for molecular MRI to generate sufficient signal change. The biological processes described above and their accompanying molecular and cellular events create numerous opportunities for targeting the atherosclerotic plaque. This can be done using nanoparticles carrying an imaging modality and targeting vector. Several novel nanoparticle platforms have emerged in molecular MRI that allows the visualization of atherosclerotic plaques. These contrast agents targeting molecules on different plaque components will be highlighted here in the context of their relevance to plaque vulnerability and summarized in the Table. Intraplaque Targeting R E T R A C T E D A R T I C L Eby Lesional MacrophagesIn the last years, it has become accepted that classically activated macrophages (or M1) and alternatively activated MØ (or M2) are 2 extremes of a spectrum of macrophage phenotypes that both contribute to plaque development progression and vulnerability. 10Macrophages Myeloid-related protein (Mrp)-8/14 is a member of the S100-family of Ca 2+ -modulated proteins with a role for the Mrp-complex in the innate inflammatory response to injury. Mrp-8/14 is detected in nonfoam cell macrophages in human and mouse atherosclerotic plaques with rupture-prone lesions.11 Levels of Mrp also have been shown to be an independently prognostic marker of cardiovascular risk. ) and MDA were developed to deliver Mn into a cell resulting in >20-fold increases in MR efficacy compared with the chelated form. 18 In vivo plaque imaging findings with these Mn-based compounds were comparable with the previous results with iron and Gd; ho...

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Section: 36mentioning

confidence: 99%

Molecular Magnetic Resonance Imaging for the Detection of Vulnerable Plaques

Adel

Daemen²,

Poelmann³

et al. 2021

ATVB

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“…The utility of targeted perfluorocarbon nanoparticles has been demonstrated for a variety of applications in animal models including the diagnosis of ruptured plaque, the quantification and antiangiogenic treatment of atherosclerotic plaque and the localization and delivery of antirestenotic therapy following angioplasty [29] . Nanoscale particles can be synthetically designed to potentially intervene in lipoprotein matrix retention and lipoprotein uptake in cells -processes central to atherosclerosis.…”

Section: Nanocardiologymentioning

confidence: 99%

Nanomedicine: Application of Nanobiotechnology in Medical Practice

Jain¹

2008

Med Princ Pract

206

126

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Nanomedicine is the application of nanobiotechnologies to medicine. This article starts with the basics of nanobiotechnology, followed by its applications in molecular diagnostics, nanodiagnostics, and improvements in the discovery, design and delivery of drugs, including nanopharmaceuticals. It will improve biological therapies such as vaccination, cell therapy and gene therapy. Nanobiotechnology forms the basis of many new devices being developed for medicine and surgery such as nanorobots. It has applications in practically every branch of medicine and examples are presented of those concerning cancer (nanooncology), neurological disorders (nanoneurology), cardiovascular disorders (nanocardiology), diseases of bones and joints (nanoorthopedics), diseases of the eye (nanoophthalmology), and infectious diseases. Safety issues of in vivo use of nanomaterials are also discussed. Nanobiotechnology will facilitate the integration of diagnostics with therapeutics and facilitate the development of personalized medicine, i.e. prescription of specific therapeutics best suited for an individual. Many of the developments have already started and within a decade a definite impact will be felt in the practice of medicine.

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“…Moreover, MR signal intensity enhancement correlated well with integrin αvβ3 expression levels. Lanza et al 36 have developed a highly MRI sensitive nanosystem that has a perfluorocarbon core covered with a monolayer of lipids. Paramagnetic lipids (eg, gadolinium-diethylenetriaminepentaacetic acid-bis-oleate) were incorporated into the lipid monolayer for detection with MRI.…”

Section: Mr Molecular Imaging Of Tumor Angiogenesis By Targeting Intementioning

confidence: 99%

A concise review of magnetic resonance molecular imaging of tumor angiogenesis by targeting integrin αvβ3 with magnetic probes

Liu¹,

Yang²,

Zhang³

2013

IJN

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Angiogenesis is an essential step for the growth and spread of malignant tumors. Accurate detection and quantification of tumor angiogenesis is important for early diagnosis of cancers as well as post therapy assessment of antiangiogenic drugs. The cell adhesion molecule integrin αvβ3 is a specific marker of angiogenesis, which is highly expressed on activated and proliferating endothelial cells, but generally not on quiescent endothelial cells. Therefore, in recent years, many different approaches have been developed for imaging αvβ3 expression, for the detection and characterization of tumor angiogenesis. The present review provides an overview of the current status of magnetic resonance molecular imaging of integrin αvβ3, including the new development of high sensitive contrast agents and strategies for improving the specificity of targeting probes and the biological effects of imaging probes on αvβ3 positive cells.

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Nanomedicine Opportunities for Cardiovascular Disease with Perfluorocarbon Nanoparticles

Cited by 65 publications

References 49 publications

Molecular Magnetic Resonance Imaging for the Detection of Vulnerable Plaques

Molecular Magnetic Resonance Imaging for the Detection of Vulnerable Plaques

Nanomedicine: Application of Nanobiotechnology in Medical Practice

A concise review of magnetic resonance molecular imaging of tumor angiogenesis by targeting integrin αvβ3 with magnetic probes

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Nanomedicine Opportunities for Cardiovascular Disease with Perfluorocarbon Nanoparticles

Cited by 65 publications

References 49 publications

Molecular Magnetic Resonance Imaging for the Detection of Vulnerable Plaques

Molecular Magnetic Resonance Imaging for the Detection of Vulnerable Plaques

Nanomedicine: Application of Nanobiotechnology in Medical Practice

A concise review of magnetic resonance molecular imaging of tumor angiogenesis by targeting integrin &alpha;v&beta;3 with magnetic probes

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A concise review of magnetic resonance molecular imaging of tumor angiogenesis by targeting integrin αvβ3 with magnetic probes