Nanomedicine in Cancer Treatment

Kim, Ji‐Eun; Cho, Myung‐Haing

doi:10.1002/9781118856017.ch10

Cited by 2 publications

(1 citation statement)

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“…Further advances in medicine and nanotechnology lead to the development of challenging approaches that aim to overcome the limits of traditional cancer therapeutics [40][41][42][43][44]. Nanomedicine-based techniques are used not only in clinical diagnosis for tumor detection, but also in the formulation and release of drugs with anticancer activity.…”

Section: Introductionmentioning

confidence: 99%

Responsive Supramolecular Polymers for Diagnosis and Treatment

Martínez-Orts,

Pujals

2024

IJMS

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Stimuli-responsive supramolecular polymers are ordered nanosized materials that are held together by non-covalent interactions (hydrogen-bonding, metal-ligand coordination, π-stacking and, host–guest interactions) and can reversibly undergo self-assembly. Their non-covalent nature endows supramolecular polymers with the ability to respond to external stimuli (temperature, light, ultrasound, electric/magnetic field) or environmental changes (temperature, pH, redox potential, enzyme activity), making them attractive candidates for a variety of biomedical applications. To date, supramolecular research has largely evolved in the development of smart water-soluble self-assemblies with the aim of mimicking the biological function of natural supramolecular systems. Indeed, there is a wide variety of synthetic biomaterials formulated with responsiveness to control and trigger, or not to trigger, aqueous self-assembly. The design of responsive supramolecular polymers ranges from the use of hydrophobic cores (i.e., benzene-1,3,5-tricarboxamide) to the introduction of macrocyclic hosts (i.e., cyclodextrins). In this review, we summarize the most relevant advances achieved in the design of stimuli-responsive supramolecular systems used to control transport and release of both diagnosis agents and therapeutic drugs in order to prevent, diagnose, and treat human diseases.

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