Nanomedicine for Ocular Drug Delivery

Xu, Xin­guang; Zuo, Yi Y.

doi:10.1007/978-981-16-8984-0_32

Cited by 2 publications

(5 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 22 Given the biophysical similarities between pulmonary surfactant and the TFLL, 23 we have recently modified the CDS to make it an ideal and versatile in vitro model for studying the biophysics of the TFLL. 24 – 27 By correlating the lipidomic analysis and biophysical assays of the MLs of WT and Soat1 KO mice, our study revealed novel experimental evidence on the composition-structure-functional correlations between nonpolar lipid components in the MLF and its biophysical properties. These results may provide novel insights into the pathophysiology of MGD and DED, and biophysical behavior of the TF and TFLL.…”

mentioning

confidence: 82%

Comparative Biophysical Study of Meibomian Lipids of Wild Type and Soat1-Null Mice: Implications to Meibomian Gland Dysfunction and Dry Eye Disease

Wilkerson

et al. 2023

Invest. Ophthalmol. Vis. Sci.

Self Cite

View full text Add to dashboard Cite

Purpose The biophysical roles of Meibomian lipids (MLs) played in health and meibomian gland dysfunction (MGD) are still unclear. The purpose of this research is to establish the composition-structure-functional correlations of the ML film (MLF) using Soat1 -null mice and comprehensive in vitro biophysical simulations. Methods MLs were extracted from tarsal plates of wild type (WT) and Soat1 knockout (KO) mice. The chemical composition of ML samples was characterized using liquid chromatography – mass spectrometry. Comprehensive biophysical studies of the MLFs, including their dynamic surface activity, interfacial rheology, evaporation resistance, and ultrastructure and topography, were performed with a novel experimental methodology called the constrained drop surfactometry. Results Soat1 inactivation caused multiple alternations in the ML profile. Compared to their WT siblings, the MLs of KO mice were completely devoid of cholesteryl esters (CEs) longer than C 18 to C 20 , but contained 7 times more free cholesterol (Chl). Biophysical assays consistently suggested that the KO-MLF became stiffer than that of WT mice, revealed by reduced film compressibility, increased elastic modulus, and decreased loss tangent, thus causing more energy loss per blinking cycle of the MLF. Moreover, the KO mice showed thinning of their MLF, and reduced evaporation resistance. Conclusions These findings delineated the composition-structure-functional correlations of the MLF and suggested a potential biophysical function of long-chain CEs in optimizing the surface activity, interfacial rheology, and evaporation resistance of the MLF. This study may provide novel implications to pathophysiological and translational understanding of MGD and dry eye disease.

show abstract

mentioning

confidence: 82%

Comparative Biophysical Study of Meibomian Lipids of Wild Type and Soat1-Null Mice: Implications to Meibomian Gland Dysfunction and Dry Eye Disease

Wilkerson

et al. 2023

Invest. Ophthalmol. Vis. Sci.

Self Cite

View full text Add to dashboard Cite

show abstract

“…The tear film is the first hindrance for topically applied drugs, often referred to as a dynamic (physiological) ocular barrier ( Figure 1 B) due to its high turnover rate, (0.5–2.2 µL/min), determining a short ocular residence time, and limited drug penetration ability [ 9 , 52 , 53 ]. Spread onto the corneal and conjunctival epithelium, it provides a smooth and lubricated optical surface, prevents the occurrence of infections due to its antimicrobial compounds (lysozyme, lactoferrin, lipocalin), or by washing out foreign substances, and supplies oxygen and nutrients to the cornea [ 54 ].…”

Section: Eye Anatomy Barriers and Routes In Ocular Drug Deliverymentioning

confidence: 99%

“…Regarding ocular delivery, both layers exhibit barrier functions, the lipid one for hydrophilic drugs and the muco-aqueous layer for hydrophobic drugs [ 58 ]. Other precorneal factors negatively influencing ocular bioavailability include drug binding with proteins/mucin in the tear film, as well as drug loss via nasolacrimal drainage [ 53 ]. The latter is affected by the volume of applied drops (larger volumes correspond to more significant loss) and the blink reflex [ 9 , 12 ].…”

Section: Eye Anatomy Barriers and Routes In Ocular Drug Deliverymentioning

confidence: 99%

“…The conjunctiva is a transparent mucous membrane, which overlays the anterior ocular surface and the interior of the eyelids. It is involved in the production of mucus and the maintenance of the tear film, ensuring the lubrication of the eye, and also preventing the entrance of exogenous substances or microorganisms [ 53 , 72 ]. The conjunctiva may be divided into three areas: the bulbar conjunctiva, covering the anterior part of the sclera; the conjunctival fornices, forming the cul-de-sac; the palpebral conjunctiva located on the posterior eyelid’s surface [ 50 ].…”

Section: Eye Anatomy Barriers and Routes In Ocular Drug Deliverymentioning

confidence: 99%

“…The ciliary body is part of the middle (vascular) layer in the eye and is involved in the maintenance of the shape of the lens via the ciliary muscle, and in the production of aqueous humor [ 53 , 81 ]. Furthermore, the ciliary epithelium and the endothelial cells of the iris blood vessels form the blood–aqueous barrier (BAB) , which prevents molecules’ entrance from systemic circulation to the aqueous humor [ 82 ].…”

Section: Eye Anatomy Barriers and Routes In Ocular Drug Deliverymentioning

confidence: 99%

See 2 more Smart Citations

Recent Progress of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers as Ocular Drug Delivery Platforms

Gugleva

Andonova

2023

Pharmaceuticals

View full text Add to dashboard Cite

Sufficient ocular bioavailability is often considered a challenge by the researchers, due to the complex structure of the eye and its protective physiological mechanisms. In addition, the low viscosity of the eye drops and the resulting short ocular residence time further contribute to the observed low drug concentration at the target site. Therefore, various drug delivery platforms are being developed to enhance ocular bioavailability, provide controlled and sustained drug release, reduce the number of applications, and maximize therapy outcomes. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) exhibit all these benefits, in addition to being biocompatible, biodegradable, and susceptible to sterilization and scale-up. Furthermore, their successive surface modification contributes to prolonged ocular residence time (by adding cationic compounds), enhanced penetration, and improved performance. The review highlights the salient characteristics of SLNs and NLCs concerning ocular drug delivery, and updates the research progress in this area.

show abstract

Nanomedicine for Ocular Drug Delivery

Cited by 2 publications

References 48 publications

Comparative Biophysical Study of Meibomian Lipids of Wild Type and Soat1-Null Mice: Implications to Meibomian Gland Dysfunction and Dry Eye Disease

Comparative Biophysical Study of Meibomian Lipids of Wild Type and Soat1-Null Mice: Implications to Meibomian Gland Dysfunction and Dry Eye Disease

Recent Progress of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers as Ocular Drug Delivery Platforms

Contact Info

Product

Resources

About