Nanomedicine for Neurological Disorder

Kumar, Narenda; Kumar, Rajiv

doi:10.1016/b978-0-323-26433-4.00003-8

Cited by 2 publications

(2 citation statements)

References 99 publications

(97 reference statements)

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“…The same metabolites influenced cellular components and environment (the endocrine, hemopoietic, immune system, metabolism pathways, and neuronal networking), and ensued kynurenine pathway, a necessity for vital cellular functioning and routes 53 . The multifactorial nature of the processes of mental illness causes an assessment of the factors that involve in determining progressions of reported mild dysfunction roots of psychiatric disorders 54 . The developing strategies (nanotheranostics and nanotherapeutics) arrest, heal, and revert these progressions responsible for neuron death.…”

Section: Insights Of Molecular Mechanisms Underlying Psychiatric Disomentioning

confidence: 99%

Review of nanotheranostics for molecular mechanisms underlying psychiatric disorders and commensurate nanotherapeutics for neuropsychiatry: The mind knockout

Kumar¹,

Chhikara²,

Gulia³

et al. 2021

Nanotheranostics

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Bio-neuronal led psychiatric abnormalities transpired by the loss of neuronal structure and function (neurodegeneration), pro-inflammatory cytokines, microglial dysfunction, altered neurotransmission, toxicants, serotonin deficiency, kynurenine pathway, and excessively produced neurotoxic substances. These uncontrolled happenings in the etiology of psychiatric disorders initiate further changes in neurotransmitter metabolism, pathologic microglial, cell activation, and impaired neuroplasticity. Inflammatory cytokines, the outcome of dysfunctional mitochondria, dysregulation of the immune system, and under stress functions of the brain are leading biochemical factors for depression and anxiety. Nanoscale drug delivery platforms, inexpensive diagnostics using nanomaterials, nano-scale imaging technologies, and ligand-conjugated nanocrystals used for elucidating the molecular mechanisms and foremost cellular communications liable for such disorders are highly capable features to study for efficient diagnosis and therapy of the mental illness. These theranostic tools made up of multifunctional nanomaterials have the potential for effective and accurate diagnosis, imaging of psychiatric disorders, and are at the forefront of leading technologies in nanotheranostics openings field as they can collectively and efficiently target the stimulated territories of the cerebellum (cells and tissues) through molecular-scale interactions with higher bioavailability, and bio-accessibility. Specifically, the nanoplatforms based neurological changes are playing a significant role in the diagnosis of psychiatric disorders and portraying the routes of functional restoration of mental disorders by newer imaging tools at nano-level in all directions. Because of these nanotherapeutic platforms, the molecules of nanomedicine can penetrate the Blood-Brain Barrier with an increased half-life of drug molecules. The discoveries in nanotheranostics and nanotherapeutics inbuilt unique multi-functionalities are providing the best multiplicities of novel nanotherapeutic potentialities with no toxicity concerns at the level of nano range.

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Section: Insights Of Molecular Mechanisms Underlying Psychiatric Disomentioning

confidence: 99%

Review of nanotheranostics for molecular mechanisms underlying psychiatric disorders and commensurate nanotherapeutics for neuropsychiatry: The mind knockout

Kumar¹,

Chhikara²,

Gulia³

et al. 2021

Nanotheranostics

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“…In the context of treating AD, these types of nanosystems could efficiently carry and deliver drugs and other neuroprotective molecules to the brain. 4,318,319 The intranasal route plays a role in overcoming the BBB and targeting the drugs directly to the brain. 282,[319][320][321][322][323][324][325] However, the oral, dermal, and intravenous routes can be used to administration of nanodevices …”

Section: Remarks and Challengesmentioning

confidence: 99%

Nanotechnology-based drug delivery systems for the treatment of Alzheimer’s disease

Fonseca-Santos¹,

Chorilli²,

Gremião³

2015

IJN

247

160

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Alzheimer’s disease is a neurological disorder that results in cognitive and behavioral impairment. Conventional treatment strategies, such as acetylcholinesterase inhibitor drugs, often fail due to their poor solubility, lower bioavailability, and ineffective ability to cross the blood–brain barrier. Nanotechnological treatment methods, which involve the design, characterization, production, and application of nanoscale drug delivery systems, have been employed to optimize therapeutics. These nanotechnologies include polymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid carriers, microemulsion, nanoemulsion, and liquid crystals. Each of these are promising tools for the delivery of therapeutic devices to the brain via various routes of administration, particularly the intranasal route. The objective of this study is to present a systematic review of nanotechnology-based drug delivery systems for the treatment of Alzheimer’s disease.

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Nanomedicine for Neurological Disorder

Cited by 2 publications

References 99 publications

Review of nanotheranostics for molecular mechanisms underlying psychiatric disorders and commensurate nanotherapeutics for neuropsychiatry: The mind knockout

Review of nanotheranostics for molecular mechanisms underlying psychiatric disorders and commensurate nanotherapeutics for neuropsychiatry: The mind knockout

Nanotechnology-based drug delivery systems for the treatment of Alzheimer’s disease

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Nanomedicine for Neurological Disorder

Cited by 2 publications

References 99 publications

Review of nanotheranostics for molecular mechanisms underlying psychiatric disorders and commensurate nanotherapeutics for neuropsychiatry: The mind knockout

Review of nanotheranostics for molecular mechanisms underlying psychiatric disorders and commensurate nanotherapeutics for neuropsychiatry: The mind knockout

Nanotechnology-based drug delivery systems for the treatment of Alzheimer&rsquo;s disease

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Product

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About

Nanotechnology-based drug delivery systems for the treatment of Alzheimer’s disease