Nanomedicine for combinational anticancer drug therapeutics: Recent advances, challenges, and future perspectives

Rahman, Mahfoozur; Beg, Sarwar; Alam, Kainat; Ahmad, Farhan Jalees

doi:10.1016/b978-0-12-821095-6.00001-x

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Nanocarriers Of Platinum and Palladium Complexes1

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2021

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“…Relative to cisplatin, it significantly suppresses the proliferation of A549 lung cancer cells. This is probably due to stimulation of p53 protein and initiation of apoptosis [ 84 ].…”

Section: Nanocarriers Of Platinum and Palladium Complexesmentioning

confidence: 99%

Platinum and Palladium Complexes as Promising Sources for Antitumor Treatments

Czarnomysy

Radomska

Szewczyk

et al. 2021

IJMS

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There is a need for new, safer, and more effective agents to treat cancer. Cytostatics that have transition metals at their core have attracted renewed interest from scientists. Researchers are attempting to use chemotherapeutics, such as cisplatin, in combination therapy (i.e., in order to enhance their effectiveness). Moreover, studies are being carried out to modify molecules, by developing them into multinuclear structures, linking different compounds to commonly used drugs, or encapsulating them in nanoparticles to improve pharmacokinetic parameters, and increase the selectivity of these drugs. Therefore, we attempted to organize recent drug findings that contain palladium and platinum atoms in their structures.

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“…Relative to cisplatin, it significantly suppresses the proliferation of A549 lung cancer cells. This is probably due to stimulation of p53 protein and initiation of apoptosis [ 84 ].…”

Section: Nanocarriers Of Platinum and Palladium Complexesmentioning

confidence: 99%