Nanomedicine-based immunotherapy for Alzheimer's disease

Hoque, Mehboob; Samanta, Arijit; Alam, Syed Sahajada Mahafujul; Zughaibi, Torki A.; Kamal, Mohammad Amjad; Tabrez, Shams

doi:10.1016/j.neubiorev.2022.104973

Cited by 13 publications

(6 citation statements)

References 99 publications

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“…Numerous nanotechnologies‐based delivery systems have been developed to enhance biological activities and specific targeting 80–83 . Several researchers have demonstrated the effectiveness of nano‐therapeutic techniques to improve the delivery and transport of curcumin in vivo and in vitro using polymers, liposomes, cyclodextrins, conjugates, dendrimers, micelles, and nanostructures 84,85 .…”

Section: Nanotechnology‐based Curcumin Delivery Platformsmentioning

confidence: 99%

“…Numerous nanotechnologies-based delivery systems have been developed to enhance biological activities and specific targeting. [80][81][82][83] Several researchers have demonstrated the effectiveness of nanotherapeutic techniques to improve the delivery and transport of curcumin in vivo and in vitro using polymers, liposomes, cyclodextrins, conjugates, dendrimers, micelles, and nanostructures. 84,85 The encapsulation of curcumin in poly(lactic-co-glycolic acid) nanoparticles (NPs) has shown significantly enhanced therapeutic efficacy and oral bioavailability compared with free curcumin.…”

Section: Nanotechnology-based Curcumin Delivery Platformsmentioning

confidence: 99%

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Curcumin, its derivatives, and their nanoformulations: Revolutionizing cancer treatment

Ahmad,

Ahmad

et al. 2024

Cell Biochemistry & Function

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Curcumin is a natural compound derived from turmeric and can target malignant tumor molecules involved in cancer propagation. It has potent antioxidant activity, but its effectiveness is limited due to poor absorption and rapid elimination from the body. Various curcumin derivatives have also shown anticancer potential in in‐vitro and in‐vivo models. Curcumin can target multiple signaling pathways involved in cancer development/progression or induce cancer cell death through apoptosis. In addition, curcumin and its derivatives could also enhance the effectiveness of conventional chemotherapy, radiation therapy and reduce their associated side effects. Lately, nanoparticle‐based delivery systems are being developed/explored to overcome the challenges associated with curcumin's delivery, increasing its overall efficacy. The use of an imaging system to track these formulations could also give beneficial information about the bioavailability and distribution of the nano‐curcumin complex. In conclusion, curcumin holds significant promise in the fight against cancer, especially in its nanoform, and could provide precise delivery to cancer cells without affecting normal healthy cells.

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Section: Nanotechnology‐based Curcumin Delivery Platformsmentioning

confidence: 99%

Section: Nanotechnology-based Curcumin Delivery Platformsmentioning

confidence: 99%

Curcumin, its derivatives, and their nanoformulations: Revolutionizing cancer treatment

Ahmad,

Ahmad

et al. 2024

Cell Biochemistry & Function

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“…Leveraging the advantages of nanotechnology, such as enhanced structure size, surface area, loading capacity, penetration, and improved uptake by target cells, nano-delivery holds great potential in revolutionizing the immunotherapeutic approach to AD. [225][226][227] Loureiro et al engineered polyethylene glycolated liposomes, which were modified with two mAbs, anti-Transferrin Receptor mAb and anti-Abeta mAb, to target and treat AD. In vivo, experiments conducted on wild-type rats revealed that the bi-ligand coupling strategy significantly enhanced drug delivery to the brain.…”

Section: Nanomedicine and Immunotherapymentioning

confidence: 99%

A Journey of Challenges and Victories: A Bibliometric Worldview of Nanomedicine since the 21st Century

Wang,

Zhao,

Zhang

et al. 2024

Advanced Materials

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Nanotechnology profoundly affects the advancement of medicine. Limitations in diagnosing and treating cancer and chronic diseases promote the growth of nanomedicine. However, there are very few analytical and descriptive studies regarding the trajectory of nanomedicine, key research powers, present research landscape, focal investigative points, and future outlooks. Herein, articles and reviews published in the Science Citation Index Expanded of Web of Science Core Collection from first January 2000 to 18th July 2023 are analyzed. Herein, a bibliometric visualization of publication trends, countries/regions, institutions, journals, research categories, themes, references, and keywords is produced and elaborated. Nanomedicine‐related academic output is increasing since the COVID‐19 pandemic, solidifying the uneven global distribution of research performance. While China leads in terms of publication quantity and has numerous highly productive institutions, the USA has advantages in academic impact, commercialization, and industrial value. Nanomedicine integrates with other disciplines, establishing interdisciplinary platforms, in which drug delivery and nanoparticles remain focal points. Current research focuses on integrating nanomedicine and cell ferroptosis induction in cancer immunotherapy. The keyword “burst testing” identifies promising research directions, including immunogenic cell death, chemodynamic therapy, tumor microenvironment, immunotherapy, and extracellular vesicles. The prospects, major challenges, and barriers to addressing these directions are discussed.

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“…[112] Different kinds of low-nano-formulations applying for different therapeutic targets have been exploited to improve the efficacy of immunotherapy for AD. [113][114] For example, p-Tau can trigger dysfunction in the mitochondria of cells, affecting cell metabolism and oxidative stress response. Tau phosphorylation inhibition can reduce mitochondrial damage to treat AD.…”

Section: Low-dimensional Nanomaterialsmentioning

confidence: 99%

Alzheimer's Disease: Status of Low‐Dimensional Nanotherapeutic Materials

Huang,

Liao,

et al. 2023

Adv Funct Materials

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Alzheimer's disease (AD) is a chronic progressive neurodegenerative disease that constitutes the third most common cause of death among elderly individuals. AD patients suffer from behavioral problems regularly, like memory loss, thinking deficits, and cognitive disorders. Currently, the incidence rate of AD has been on the rise worldwide. Therefore, it is imperative to develop effective strategies for the treatment and prevention of AD. The inherent characteristics of low‐dimensional nanomaterials, primarily their smaller size and surface structure, make them well‐suited for fulfilling the essential requirements of therapeutic drug design. Consequently, these nanomaterials offer a highly appealing and alternative approach to treating AD. Here, the low‐dimensional nanomaterials used in the treatment of AD to provide new ideas, methods, and comprehensive perspectives for the management of AD are reviewed. This review will advance the comprehensive understanding of the potential of low‐dimensional nanomaterials in the field of neuro medicine, which also will have a positive impact on future research.

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Nanomedicine-based immunotherapy for Alzheimer's disease

Cited by 13 publications

References 99 publications

Curcumin, its derivatives, and their nanoformulations: Revolutionizing cancer treatment

Curcumin, its derivatives, and their nanoformulations: Revolutionizing cancer treatment

A Journey of Challenges and Victories: A Bibliometric Worldview of Nanomedicine since the 21st Century

Alzheimer's Disease: Status of Low‐Dimensional Nanotherapeutic Materials

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