Nanomedicine applications in women&amp;#39;s health: state of the art

Lloyd-Parry, Oliver; Downing, Charlotte; Aleisaei, Eisa; Jones, Céline; Coward, Kevin

doi:10.2147/ijn.s97572

Cited by 20 publications

(19 citation statements)

References 202 publications

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“…Overall, the data showed that SLNs can be used to improve the efficacy of antidepressants [ 68 ]. In another research study where the antidepressant, duloxetine was encapsulated in SLNs, the oral bioavailability of the drug was improved owing to reduced first-pass metabolism of the duloxetine-SLN system when compared with duloxetine only [ 69 ]. The drug–nanoparticle formulation was stable under acidic media and it displayed improved pharmacological properties in vivo.…”

Section: Nanocarriers Employed As Therapeutic Delivery Platforms Of Antidepressantsmentioning

confidence: 99%

Advances in Nano-Enabled Platforms for the Treatment of Depression

et al. 2021

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Nanotechnology has aided in the advancement of drug delivery for the treatment of several neurological disorders including depression. Depression is a relatively common mental disorder which is characterized by a severe imbalance of neurotransmitters. Several current therapeutic regimens against depression display drawbacks which include low bioavailability, delayed therapeutic outcome, undesirable side effects and drug toxicity due to high doses. The blood–brain barrier limits the entry of the drugs into the brain matrix, resulting in low bioavailability and tissue damage due to drug accumulation. Due to their size and physico-chemical properties, nanotechnological drug delivery systems present a promising strategy to enhance the delivery of nanomedicines into the brain matrix, thereby improving bioavailability and limiting toxicity. Furthermore, ligand-complexed nanocarriers can improve drug specificity and antidepressant efficacy and reduce drug toxicity. Biopolymers and nanocarriers can also be employed to enhance controlled drug release and reduce the hepatic first-pass effect, hence reducing the dosing frequency. This manuscript reviews recent advances in different biopolymers, such as polysaccharides and other nanocarriers, for targeted antidepressant drug delivery to the brain. It probes nano-based strategies that can be employed to enhance the therapeutic efficacy of antidepressants through the oral, intranasal, and parenteral routes of administration.

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Section: Nanocarriers Employed As Therapeutic Delivery Platforms Of Antidepressantsmentioning

confidence: 99%

Advances in Nano-Enabled Platforms for the Treatment of Depression

et al. 2021

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“…Magnetic nanoparticles are ever used in nanostructured bisphosphonate (Bis)-conjugated iron (II, III) oxide (Fe3O4), while hydroxyapatite nanoparticles are used in nanostructured risedronate/ zinchydroxyapatite. 25 A nanoparticle is a term for a particle that has a size of less than 100 nm. 26 The bone structure is composed of nano-sized components that using a nanoparticle to target this site is no longer an impossible mission.…”

Section: Magnetic Nanoparticle As Osteoporosis Therapymentioning

confidence: 99%

The Potential of Soy Isoflavones (Glycine max) and Magnetic Hydroxyapatite Nanoparticles as Osteoporosis Therapy for Menopausal Women

Jannah

Ebnudesita

Dienanta

et al. 2020

IABJ

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Background: Menopausal women experience amenorrhea for 12 consecutive months. In Indonesia, one of four women aged 50 – 80 years has a risk of osteoporosis. This age range is related to the menopause phase. Low estrogen levels in menopausal women cause decreased bone mineral density resulting in osteoporosis. Osteoporosis is a degenerative disease characterized by decreased bone density and bone strength that causes fractures. This literature review aims to determine the potential of soy isoflavones (Glycine max) and magnetic hydroxyapatite nanoparticles as alternative therapies for osteoporosis in menopausal women. Reviews: Soy isoflavones are phytoestrogens because they have estrogen-like structures and functions. Some studies explain that phytoestrogens have benefits in osteoporosis therapy by maintaining bone density through decreasing osteoclast resorption and stimulating osteoblasts. Consuming enough soy supplements everyday has been shown to increase bone mineral density. This effect is strengthened by coating the soy isoflavones with magnetic hydroxyapatite nanoparticles through two mechanisms, as a therapeutic agent and drug carrier. The magnetic field of the magnetic nanoparticles produces force and torque to increase the temperature until 42°C and trigger organelles movement, causing apoptosis of osteoclasts. Hydroxyapatite is a major component of bone mineral that replaces bone tissue deformity and has an osteoblastic effect in bone regeneration. Nano-sized hydroxyapatite will increase material properties and stability in high temperatures. However, hydroxyapatite has less magnetic activity so this function is completed by magnetic nanoparticles. Summary: Therefore, the combination of soy isoflavones and magnetic hydroxyapatite nanoparticles works synergistically as an alternative therapy for osteoporosis in menopausal women.

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“…Nanomedicine is the application of the principles and methods of nanoscience and technology to medicine, aimed at developing more sensitive and rapid medical methods and understanding the processes and mechanisms of life activities at the more micro or nano level (Albanese, Tang, & Chan, 2012; Bregoli et al, 2016; Emerich, 2005; Lloyd‐Parry, Downing, Aleisaei, Jones, & Coward, 2018). Worldwide it is evident that there is increasing emphasis on biomedical applications of a wide range of nanomaterials including silica nanoparticles (SNPs), superparamagnetic iron oxide nanoparticles, gold nanoparticles, and graphene and metal organic frameworks (Cheng, Deng, Lin, Cai, & Zink, 2019; Darweesh, Ayoub, & Nazzal, 2019; Rive et al, 2019; Yan et al, 2019; Zhong, Kankala, Wang, & Chen, 2019).…”

Section: Introductionmentioning

confidence: 99%

Understanding the mechanisms of silica nanoparticles for nanomedicine

Peng

et al. 2020

WIREs Nanomed Nanobiotechnol

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As a consequence of recent progression in biomedicine and nanotechnology, nanomedicine has emerged rapidly as a new discipline with extensive application of nanomaterials in biology, medicine, and pharmacology. Among the various nanomaterials, silica nanoparticles (SNPs) are particularly promising in nanomedicine applications due to their large specific surface area, adjustable pore size, facile surface modification, and excellent biocompatibility. This paper reviews the synthesis of SNPs and their recent usage in drug delivery, biomedical imaging, photodynamic and photothermal therapy, and other applications. In addition, the possible adverse effects of SNPs in nanomedicine applications are reviewed from reported in vitro and in vivo studies. Finally, the potential opportunities and challenges for the future use of SNPs are discussed. This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Therapeutic Approaches and Drug Discovery > Emerging Technologies

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Nanomedicine applications in women's health: state of the art

Cited by 20 publications

References 202 publications

Advances in Nano-Enabled Platforms for the Treatment of Depression

Advances in Nano-Enabled Platforms for the Treatment of Depression

The Potential of Soy Isoflavones (Glycine max) and Magnetic Hydroxyapatite Nanoparticles as Osteoporosis Therapy for Menopausal Women

Understanding the mechanisms of silica nanoparticles for nanomedicine

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