“…A scaffold is an artificial framework used for the formation of three–dimensional (3D) tissues, cell attachment and migration, and cell transport and retention, as well as the diffusion of essential nutrients and released products [ 4 ]. Scaffolds are expected to meet certain parameters, including excellent biodegradability, biocompatibility, a porous structure to facilitate cellular growth to help in tissue regeneration, and the controlled stimulation of the anticipated biological response to produce the desired product, which can be mostly tissue or organs [ 5 , 6 ] ( Figure 1 ). These scaffolds can be altered to be formed at the nanoscale or microscale, which is expected to favor or regulate biological factors/growth factor releases [ 7 , 8 ].…”
Biological macromolecules like polysaccharides/proteins/glycoproteins have been widely used in the field of tissue engineering due to their ability to mimic the extracellular matrix of tissue. In addition to this, these macromolecules are found to have higher biocompatibility and no/lesser toxicity when compared to synthetic polymers. In recent years, scaffolds made up of proteins, polysaccharides, or glycoproteins have been highly used due to their tensile strength, biodegradability, and flexibility. This review is about the fabrication methods and applications of scaffolds made using various biological macromolecules, including polysaccharides like chitosan, agarose, cellulose, and dextran and proteins like soy proteins, zein proteins, etc. Biopolymer-based nanocomposite production and its application and limitations are also discussed in this review. This review also emphasizes the importance of using natural polymers rather than synthetic ones for developing scaffolds, as natural polymers have unique properties, like high biocompatibility, biodegradability, accessibility, stability, absence of toxicity, and low cost.
“…A scaffold is an artificial framework used for the formation of three–dimensional (3D) tissues, cell attachment and migration, and cell transport and retention, as well as the diffusion of essential nutrients and released products [ 4 ]. Scaffolds are expected to meet certain parameters, including excellent biodegradability, biocompatibility, a porous structure to facilitate cellular growth to help in tissue regeneration, and the controlled stimulation of the anticipated biological response to produce the desired product, which can be mostly tissue or organs [ 5 , 6 ] ( Figure 1 ). These scaffolds can be altered to be formed at the nanoscale or microscale, which is expected to favor or regulate biological factors/growth factor releases [ 7 , 8 ].…”
Biological macromolecules like polysaccharides/proteins/glycoproteins have been widely used in the field of tissue engineering due to their ability to mimic the extracellular matrix of tissue. In addition to this, these macromolecules are found to have higher biocompatibility and no/lesser toxicity when compared to synthetic polymers. In recent years, scaffolds made up of proteins, polysaccharides, or glycoproteins have been highly used due to their tensile strength, biodegradability, and flexibility. This review is about the fabrication methods and applications of scaffolds made using various biological macromolecules, including polysaccharides like chitosan, agarose, cellulose, and dextran and proteins like soy proteins, zein proteins, etc. Biopolymer-based nanocomposite production and its application and limitations are also discussed in this review. This review also emphasizes the importance of using natural polymers rather than synthetic ones for developing scaffolds, as natural polymers have unique properties, like high biocompatibility, biodegradability, accessibility, stability, absence of toxicity, and low cost.
The use of nanotechnology in healthcare and medicine is crucial, particularly for nanocoatings. The therapeutic potential of nanocoatings on medical implants and devices is examined in this chapter. It goes into the ingredients, production processes, and health benefits of nanocoatings. Device functionality and biocompatibility can be enhanced by nanocoatings. They are essential in addressing healthcare issues including cardiovascular stents and orthopedic implants. Additionally, nanocoatings are used in medication delivery systems, tissue engineering, and wound healing. This chapter offers important knowledge on the medical applications of nanocoatings to experts and researchers. Nanotechnology has the potential to alter the medical industry, which would be advantageous for patients.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.