Nanomechanical biosensors: a new sensing tool

Carrascosa, Laura G.; Moreno, Miguel; Álvarez, Mar; Lechuga, Laura M.

doi:10.1016/j.trac.2005.09.006

Cited by 260 publications

(144 citation statements)

References 62 publications

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“…Microfabricated cantilevers have proven to be a promising label-free sensing platform for a large variety of biomolecules [1][2][3][4]. Cantilever sensors can operate in either resonant mode (resonant frequency shift) or static mode (static bending).…”

Section: Introductionmentioning

confidence: 99%

Optical Lever Based Parylene Cantilevers for Biochemical Sensing

Zheng¹,

Khalid²,

Wang³

et al. 2008

TOOPTSJ

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This paper reports the development of optical lever based parylene cantilevers for biochemical sensing. A simple but effective process to fabricate parylene cantilevers using Tetramethylammonium Hydroxide (TMAH) bulkmicromachining was demonstrated. A scheme of using anchoring holes was employed to prevent the peeling off of parylene during TMAH etching. Moreover, ridge structures were incorporated on the cantilever tip to achieve a flat surface for a well-controlled reflected laser spot. An analytical model was presented to guide the design of the cantilever sensor. The stability of the parylene cantilever sensor in water and buffer solution was demonstrated. Based on optical lever method, the parylene cantilevers successfully detected vapour phase alkanethiols, and DNA molecules in buffer solution.

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Section: Introductionmentioning

confidence: 99%

Optical Lever Based Parylene Cantilevers for Biochemical Sensing

Zheng¹,

Khalid²,

Wang³

et al. 2008

TOOPTSJ

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“…Application of nanomechanical sensors to biosensing has become in the last 15 years a breakthrough in biochemistry, life science and medicine, depicting how nanomechanics and biology can grow together [6,8,9]. Research in this direction is growing substantially after the milestone work of Fritz and coworkers in 2000, in which they report the specific transduction driven by the surface stress change of DNA hybridization without reported labels [6].…”

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confidence: 99%

Surface Nanomechanics of Biomolecules and Supramolecular Systems

Bergese¹,

Federici²

2017

Nanomechanics

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Surface nanomechanics of biomolecules and supramolecular systems is an interdisciplinary and vital area of current research, with implications/applications spanning from synthetic biology to regenerative medicine, from smart surfaces to molecular machines. Biomolecule surface transformations and nanomachinery arise upon "wiring" them onto surfaces and interfaces. Surface confinement of biomolecules is a common feature of biological systems (e.g., cell membranes) and often a mandatory step for translating their properties into real-world applications (e.g., biosensors). On surfaces biomolecules undergo peculiar transformations and interactions which they do not experience in solution. Such unedited effects open challenges in synthetic systems, for example, by altering or hindering the designed/expected property, but also disclose a wealth of opportunities and surprises. Based on our latest research, this chapter will bring fresh excerpts from the field. It will start with an accessible description of thermodynamics of surface nanomechanics of biomolecules and supramolecular systems and then will show how it can be implemented to gain understanding of grow factor cell signaling, to single out small ligands able to inhibit protein misfolding, to measure energetics of surface confined ferritin during iron loading, and to realize a universal probe for ammine-based designer drugs.

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“…13 However, their functionalization is required to reach high enough selectivity for the biomolecules detection. 14 In this work, we realize a prototype of the piezoelectric resonator based on a single FF microtube with high enough resonance frequency and quality factor to be used in above mentioned applications.…”

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confidence: 99%

Piezoelectric resonators based on self-assembled diphenylalanine microtubes

Bosne

Heredia

Kopyl

et al. 2013

Applied Physics Letters

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Piezoelectric actuation has been widely used in microelectromechanical devices including resonance-based biosensors, mass detectors, resonators, etc. These were mainly produced by micromachining of Si and deposited inorganic piezoelectrics based on metal oxides or perovskite-type materials which have to be further functionalized in order to be used in biological applications. In this work, we demonstrate piezoelectrically driven micromechanical resonators based on individual self-assembled diphenylalanine microtubes with strong intrinsic piezoelectric effect. Tubes of different diameters and lengths were grown from the solution and assembled on a rigid support. The conducting tip of the commercial atomic force microscope was then used to both excite vibrations and study resonance behavior. Efficient piezoelectric actuation at the fundamental resonance frequency ≈2.7 MHz was achieved with a quality factor of 114 for a microtube of 277 μm long. A possibility of using piezoelectric dipeptides for biosensor applications is discussed.

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Nanomechanical biosensors: a new sensing tool

Cited by 260 publications

References 62 publications

Optical Lever Based Parylene Cantilevers for Biochemical Sensing

Optical Lever Based Parylene Cantilevers for Biochemical Sensing

Surface Nanomechanics of Biomolecules and Supramolecular Systems

Piezoelectric resonators based on self-assembled diphenylalanine microtubes

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