Nanomaterials loaded with Quercetin as an advanced tool for cancer treatment

Caro, Carlos; Pourmadadi, Mehrab; Eshaghi, Mohammad Mahdi; Rahmani, Elham; Shojaei, Shirin; Paiva‐Santos, Ana Cláudia; Rahdar, Abbas; Behzadmehr, Razieh; García-Martín, María Luisa; Díez‐Pascual, Ana M.

doi:10.1016/j.jddst.2022.103938

Cited by 29 publications

(9 citation statements)

References 112 publications

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“…These HDs were in the range regarded as optimal for in vivo applications (≈50 nm). [ 60 ] On the contrary, unexpectedly poor stability was noticed for both ZnFe1@Fe‐PEG and ZnFe2@Fe‐PEG, suggesting that the PEGylated ligand was not able to properly interact with the NPs surface, even though alloy NPs were mainly composed of Fe.…”

Section: Resultsmentioning

confidence: 99%

Smart Design of ZnFe and ZnFe@Fe Nanoparticles for MRI‐Tracked Magnetic Hyperthermia Therapy: Challenging Classical Theories of Nanoparticles Growth and Nanomagnetism

Caro,

Guzzi,

Moral‐Sánchez

et al. 2024

Adv Healthcare Materials

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Iron Oxide Nanoparticles (IONPs) hold the potential to exert significant influence on fighting cancer through their theranostics capabilities as contrast agents (CAs) for magnetic resonance imaging (MRI) and as mediators for magnetic hyperthermia (MH). In addition, these capabilities can be improved by doping IONPs with other elements. In this work, we report the synthesis and characterization of single‐core and alloy ZnFe novel magnetic nanoparticles (MNPs), with improved magnetic properties and more efficient magnetic‐to‐heat conversion. Remarkably, our results challenge classical nucleation and growth theories, which cannot fully predict the final size/shape of these nanoparticles and, consequently, their magnetic properties, implying the need for further studies to better understand the nanomagnetism phenomenon. On the other hand, leveraging the enhanced properties of these new NPs, successful tumor therapy by MH was achieved following their intravenous administration and tumor accumulation via the EPR effect. Notably, these results were obtained using a single low dose of MNPs and a single exposure to clinically suitable alternating magnetic fields (AMF). Therefore, as far as we are aware, we demonstrate, for the first time, the successful application of intravenously administered MNPs for MRI‐tracked MH tumor therapy in passively targeted tumor xenografts using clinically suitable conditions.This article is protected by copyright. All rights reserved

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Section: Resultsmentioning

confidence: 99%

Smart Design of ZnFe and ZnFe@Fe Nanoparticles for MRI‐Tracked Magnetic Hyperthermia Therapy: Challenging Classical Theories of Nanoparticles Growth and Nanomagnetism

Caro,

Guzzi,

Moral‐Sánchez

et al. 2024

Adv Healthcare Materials

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“…Quercetin research within nanotechnology is promising due to its potential to enhance bioavailability and targeted delivery, overcoming traditional limitations like poor solubility and rapid metabolism [103]. Nanotechnology-based systems aim to optimize quercetin's therapeutic use by reducing dosage and minimizing side effects [104]. Additionally, quercetin is being investigated for its synergistic effects with other treatments, particularly in cancer therapy, to improve outcomes and reduce adverse effects by modulating key biological pathways [105,106].…”

Section: Section 4: Cutting-edge Advances In Quercetin Researchmentioning

confidence: 99%

Unveiling the Potential of Quercetin: Chemistry, Health Benefits, Toxicity, and Cutting-Edge Advances

A. Ghareeb,

Z. Zayan,

H. Shari

et al. 2024

Quercetin - Effects on Human Health [Working Title]

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Quercetin, a naturally occurring flavonoid, has gained significant attention in recent years due to its potential health benefits and versatile applications. This book chapter explores the chemistry of quercetin, shedding light on its molecular structure, biosynthesis, and extraction methods. The chapter delves into the extensive research on the health effects of quercetin, highlighting its antioxidant, anti-inflammatory, anticancer, neuroprotective, and cardioprotective properties. Moreover, the potential risks and toxicity associated with quercetin consumption are thoroughly examined, emphasizing the importance of proper dosage and potential drug interactions. The chapter concludes by providing an overview of recent advances in quercetin development, including nanoformulations, targeted delivery systems, and combination therapies, that hold promise for enhancing its therapeutic efficacy and bioavailability. This comprehensive exploration of quercetin aims to provide researchers, scientists, and healthcare professionals with valuable insights into its multifaceted nature and potential applications in human health.

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“…The developed nanoformulations showed enhanced anti-tumour activity by controlling essential molecular pathways like cyclins, mitogen-activated protein kinase (MAPK) and PI3K/Akt. These formulations also showed synergistic effect in the cancer management by obstructing drug efflux regulated by transporter proteins and enhance the rate of apoptosis that ultimately results in death of cancerous cells [9]. Zinc oxide NPs were formulated for QCT targeted site delivery by Sadhukhan et al and the developed NPs resulted in increased apoptosis, destruction of breast carcinoma cells [10].…”

Section: Introductionmentioning

confidence: 99%

Quercetin nanoformulations: recent advancements and therapeutic applications

Kaur,

Goyal,

Rai

et al. 2023

Adv. Nat. Sci: Nanosci. Nanotechnol.

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Quercetin is a natural bioflavonoid and is an inevitable part of a person’s daily diet. It exhibits anti-inflammatory, anti-oxidant, anti-cancer, anti-microbial effects and is used for the treatment of several diseases like cancer, cardiovascular ailments, and microbial infections. The major limitations of quercetin are low water solubility, less chemical stability, low bioavailability, and short biological half-life. All these major drawbacks can be overcome by its encapsulation in various nanocarriers (nanoparticles, nanoliposomes, nanocrystals, nanomicelles, etc). Such quercetin encapsulated nanoformulations displayed enhanced solubility, stability, bioavailability, high encapsulation efficiency, controlled drug release and extended systemic circulation time period. Quercetin loaded nanocarriers can easily pass across different barriers like blood brain barrier (BBB), skin barriers, mucosal membrane, hence providing target site specific delivery. They also exhibited improved therapeutic effects such as enhanced anti-cancer, anti-diabetic, anti-microbial, anti-inflammatory, anti-psoriasis, anti-oxidant, anti-asthmatic, anti-acne, skin-whitening, hepatoprotective, photoprotective, neuroprotective, nephroprotective and cardioprotective actions. Major health issues associated with nanoformulations are risk of cytotoxicity, oxidative stress, DNA damage, and mutations that can be minimised with continual advancements in nanotechniques. The present review discusses quercetin, its historical background, pharmacokinetics, mechanism of action, and therapeutic applications with major emphasis on the quercetin nanoformulations such as nanoparticles, nanoemulsions, nanoliposomes, nanocrystals, nanosuspensions and nanomicelles that enhances its physicochemical stability, solubility, and therapeutic applications. Also this review includes different quercetin nanoformulations developed for colon cancer and colorectal cancer treatment, brief description of pre-clinical & clinical studies, toxicological concerns, challenges & opportunities, future aspects, patents and marketed quercetin products.

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Nanomaterials loaded with Quercetin as an advanced tool for cancer treatment

Cited by 29 publications

References 112 publications

Smart Design of ZnFe and ZnFe@Fe Nanoparticles for MRI‐Tracked Magnetic Hyperthermia Therapy: Challenging Classical Theories of Nanoparticles Growth and Nanomagnetism

Smart Design of ZnFe and ZnFe@Fe Nanoparticles for MRI‐Tracked Magnetic Hyperthermia Therapy: Challenging Classical Theories of Nanoparticles Growth and Nanomagnetism

Unveiling the Potential of Quercetin: Chemistry, Health Benefits, Toxicity, and Cutting-Edge Advances

Quercetin nanoformulations: recent advancements and therapeutic applications

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