Nanomaterials in label-free impedimetric biosensor: Current process and future perspectives

Tran, Trong Binh; Son, Sang Jun; Min, Junhong

doi:10.1007/s13206-016-0408-0

Cited by 38 publications

(17 citation statements)

References 89 publications

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“…Compared to amperometry and potentiometry, EIS is able to detect minimal changes at the sensor surface boundaries, thus leading to several advantages, such as a wide linear range, low limits of detection and direct assay mode. The method can also preserve the sample for further confirmatory analysis [14,15]. The basic principle behind EIS is the electrical impedance, which indicates the resistance that an electrical circuit presents to the flow of an alternating current (AC), generated by applying a small alternating voltage (AV) [16].…”

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confidence: 99%

Molecularly Imprinted Nanoparticles Based Sensor for Cocaine Detection

et al. 2020

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The development of a sensor based on molecularly imprinted polymer nanoparticles (nanoMIPs) and electrochemical impedance spectroscopy (EIS) for the detection of trace levels of cocaine is described in this paper. NanoMIPs for cocaine detection, synthesized using a solid phase, were applied as the sensing element. The nanoMIPs were first characterized by Transmission Electron Microscopy (TEM) and Dynamic Light Scattering and found to be ~148.35 ± 24.69 nm in size, using TEM. The nanoMIPs were then covalently attached to gold screen-printed electrodes and a cocaine direct binding assay was developed and optimized, using EIS as the sensing principle. EIS was recorded at a potential of 0.12 V over the frequency range from 0.1 Hz to 50 kHz, with a modulation voltage of 10 mV. The nanoMIPs sensor was able to detect cocaine in a linear range between 100 pg mL−1 and 50 ng mL−1 (R2 = 0.984; p-value = 0.00001) and with a limit of detection of 0.24 ng mL−1 (0.70 nM). The sensor showed no cross-reactivity toward morphine and a negligible response toward levamisole after optimizing the sensor surface blocking and assay conditions. The developed sensor has the potential to offer a highly sensitive, portable and cost-effective method for cocaine detection.

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confidence: 99%

Molecularly Imprinted Nanoparticles Based Sensor for Cocaine Detection

et al. 2020

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“…Immobilize nanoparticles as a secondary architecture to increase the surface area and improve charge transfer [101]. For capacitive sensors, implement single frequency monitoring to realize a faster and simpler system.…”

Section: How To Improvementioning

confidence: 99%

Integrated Electrochemical Biosensors for Detection of Waterborne Pathogens in Low-Resource Settings

et al. 2020

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More than 783 million people worldwide are currently without access to clean and safe water. Approximately 1 in 5 cases of mortality due to waterborne diseases involve children, and over 1.5 million cases of waterborne disease occur every year. In the developing world, this makes waterborne diseases the second highest cause of mortality. Such cases of waterborne disease are thought to be caused by poor sanitation, water infrastructure, public knowledge, and lack of suitable water monitoring systems. Conventional laboratory-based techniques are inadequate for effective on-site water quality monitoring purposes. This is due to their need for excessive equipment, operational complexity, lack of affordability, and long sample collection to data analysis times. In this review, we discuss the conventional techniques used in modern-day water quality testing. We discuss the future challenges of water quality testing in the developing world and how conventional techniques fall short of these challenges. Finally, we discuss the development of electrochemical biosensors and current research on the integration of these devices with microfluidic components to develop truly integrated, portable, simple to use and cost-effective devices for use by local environmental agencies, NGOs, and local communities in low-resource settings.

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“…In this review, we followed the transducer mechanism for label-free division, as it is more popular. Electrochemical sensors were the first reported type of biosensors [131]. The basis for this method is the chemical modification of electrodes, such as a metal surface and carbon electrodes.…”

Section: Electrospun Label-free Sensorsmentioning

confidence: 99%

Electrospun Nanofibers for Label-Free Sensor Applications

Aliheidari

Aliahmad

Agarwal

et al. 2019

Sensors

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Electrospinning is a simple, low-cost and versatile method for fabricating submicron and nano size fibers. Due to their large surface area, high aspect ratio and porous structure, electrospun nanofibers can be employed in wide range of applications. Biomedical, environmental, protective clothing and sensors are just few. The latter has attracted a great deal of attention, because for biosensor application, nanofibers have several advantages over traditional sensors, including a high surface-to-volume ratio and ease of functionalization. This review provides a short overview of several electrospun nanofibers applications, with an emphasis on biosensor applications. With respect to this area, focus is placed on label-free sensors, pertaining to both recent advances and fundamental research. Here, label-free sensor properties of sensitivity, selectivity, and detection are critically evaluated. Current challenges in this area and prospective future work is also discussed.

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Nanomaterials in label-free impedimetric biosensor: Current process and future perspectives

Cited by 38 publications

References 89 publications

Molecularly Imprinted Nanoparticles Based Sensor for Cocaine Detection

Molecularly Imprinted Nanoparticles Based Sensor for Cocaine Detection

Integrated Electrochemical Biosensors for Detection of Waterborne Pathogens in Low-Resource Settings

Electrospun Nanofibers for Label-Free Sensor Applications

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