Nanomaterials in Cancer Diagnosis and Therapy

Brero, Francesca; Gallo, Salvatore

doi:10.3390/ijms232213770

Cited by 3 publications

(3 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4 Modern nanomedicines are well suited for tumour diagnostics and treatment as they can be customized 7 and modified and have favorable body surface ratios. 8,9 Furthermore, nanomedicines accumulate in tumour tissues through the enhanced permeability and retention (EPR) effect in solid tumours. 10 The development of specific ligand-functionalized nanopreparations (Scheme 1) can enhance their ability to target tumours.…”

Section: Introductionmentioning

confidence: 99%

Bionic nanotheranostic for multimodal imaging-guided NIR-II-photothermal cancer therapy

Zhang,

Hang

et al. 2024

Nanoscale

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Bionic nanotheranostic for multimodal imaging-guided NIR-II-photothermal cancer therapy

Zhang,

Hang

et al. 2024

Nanoscale

View full text Add to dashboard Cite

show abstract

“…Current approaches to cancer treatment involve surgery, chemotherapy, and radiation therapy. Despite their efficacy \during initial treatment phases, challenges are encountered.…”

Section: Introductionmentioning

confidence: 99%

Combined Photothermal/Combination Chemotherapeutic Approach Using Zif-8-Supported Artesunate and Gold Nanorods

Li,

Wang,

et al. 2024

ACS Appl. Nano Mater.

View full text Add to dashboard Cite

Tumors pose a significant threat to human wellbeing, presenting substantial risks to lives. Conventional approaches to cancer treatment exhibit limited efficacy in eliminating the disease, leading to undesirable outcomes and an increased likelihood of disease relapse. The application of chemotherapy and photothermal therapy has recently shown an increasing trend, owing to their limited negative effects and exceptional specificity. Chemotherapy can potentially induce a rapid reduction in tumors during initial treatment. However, it carries the risk of inducing drug resistance, ultimately contributing to tumor recurrence. Combination therapy offers more advantages, than single chemotherapy. Photothermotherapy and photodynamic therapy have gained significant public interest as innovative approaches to medical treatment. Nonetheless, gold nanorods demonstrate notable potential as exceptional photothermal agents in photothermal therapy. An acidic microenvironment is commonly found in tumors. With this factor considered, a tumor-specific cleavable material is used to encapsulate the drug for facilitating controlled release exclusively within the tumor microenvironment. The combination of dequalinium chloride and artesunate increases its selectivity toward mitochondria, enhancing its effectiveness as a chemotherapy agent. The gold nanorods were successfully employed to encapsulate the drug with ZIF-8, enabling precise transportation to the tumor location while preserving its stability. The therapeutic effectiveness of the treatment on mouse models with NCI-H1299 tumors was highly satisfactory, also demonstrating high biological safety, revealing its potential capabilities in cancer therapy. It provides a research basis for nanomaterials to inhibit tumors.

show abstract

“…Modern nanomedicines are well suited for tumor diagnostics and treatment as they can be customized [8], and modi ed, and have favorable body surface ratios [9,10]. Furthermore, nanomedicines accumulate in tumor tissues through the enhanced permeability and retention (EPR) effect in solid tumors [11].…”

Section: Introductionmentioning

confidence: 99%

Bionic Nanotheranostic for Multimodal Imaging-Guided NIR-II-Photothermal Therapy of Lung Cancer

Zhang,

Hang

et al. 2023

Preprint

View full text Add to dashboard Cite

In photothermal therapy (PTT), the photothermal conversion of the second near-infrared (NIR-II) window allows deeper penetration and higher laser irradiance, and is considered a promising therapeutic strategy for deep tissues. Since lung cancer remains the leading cause of cancer-related deaths worldwide, despite the numerous treatment options, we aimed to develop an improved bionic nanotheranostic for combined imaging and photothermal therapy of lung cancer. We combined gold nanobipyramid (Au NBP) as a photothermal agent and MnO2 as a magnetic-resonance enhancer to produce core/shell structures (Au@MnO2; AM) and modified their surfaces with homologous cancer-cell plasma membranes (PM) to enable tumor targeting. The performance of the resulting Au@MnO2@PM (AMP) nanotheranostic was evaluated in vitro and in vivo. AMP exhibits photothermal properties under NIR-II laser irradiation and has multimodal in-vitro imaging functions. AMP enables the computed tomography (CT), photothermal imaging (PTI), and magnetic resonance imaging (MRI) of tumors. In particular, AMP exhibited a remarkable PTT effect on cancer cells in vitro and inhibited tumor cell growth under 1064 nm laser irradiation in vivo, with no significant systemic toxicity. This study achieved tumor therapy guided by multimodal imaging, thereby demonstrating a novel strategy for the use of bionic gold nanoparticles for tumor PTT under NIR-II laser irradiation.

show abstract

Nanomaterials in Cancer Diagnosis and Therapy

Abstract: Currently, the most commonly used treatments for cancer are surgery, radiotherapy, and chemotherapy [...]

Cited by 3 publications

References 15 publications

Bionic nanotheranostic for multimodal imaging-guided NIR-II-photothermal cancer therapy

Bionic nanotheranostic for multimodal imaging-guided NIR-II-photothermal cancer therapy

Combined Photothermal/Combination Chemotherapeutic Approach Using Zif-8-Supported Artesunate and Gold Nanorods

Bionic Nanotheranostic for Multimodal Imaging-Guided NIR-II-Photothermal Therapy of Lung Cancer

Contact Info

Product

Resources

About