Nanomaterials-Functionalized Hydrogels for the Treatment of Cutaneous Wounds

Abstract

Hydrogels have been utilized extensively in the field of cutaneous wound treatment. The introduction of nanomaterials (NMs), which are a big category of materials with diverse functionalities, can endow the hydrogels with additional and multiple functions to meet the demand for a comprehensive performance in wound dressings. Therefore, NMs-functionalized hydrogels (NMFHs) as wound dressings have drawn intensive attention recently. Herein, an overview of reports about NMFHs for the treatment of cutaneous wounds in the past five years is provided. Firstly, fabrication strategies, which are mainly divided into physical embedding and chemical synthesis of the NMFHs, are summarized and illustrated. Then, functions of the NMFHs brought by the NMs are reviewed, including hemostasis, antimicrobial activity, conductivity, regulation of reactive oxygen species (ROS) level, and stimulus responsiveness (pH responsiveness, photo-responsiveness, and magnetic responsiveness). Finally, current challenges and future perspectives in this field are discussed with the hope of inspiring additional ideas.

Recent Advances in Surface Functionalization of Magnetic Nanoparticles

“…Additionally, characterization techniques illuminate the modified surface engineering, shedding light on their structure and behavior. Conex applications such as cutaneous wound treatment have been shown to be responsive to functionalized hydrogels based on magnetic core (like Fe 3 O 4 , MnFe 2 O 4 and other ferrites) [11]. Despite the strides Coatings 2023, 13, 1772 3 of 31 made in MNP surface functionalization, several critical challenges persist.…”